Maternal vaccination as a<i>Salmonella</i>Typhimurium reduction strategy on pig farms

Smith, Richard P.; Andres, Victor; Martelli, Francesca; Gosling, Becky; Marco‐Jiménez, Francisco; Vaughan, Kelly; Tchórzewska, Monika A.; Davies, Rob

doi:10.1111/jam.13609

Cited by 19 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Farms were geographically diverse, and loosely representative of the finisher-only pig industry in GB; no farms were selected from the North West, Wales or Scotland (Supplementary Table S1) (Pig Health and Welfare Council, 2017). The farms selected were not random but an opportunistic selection of 53 farms participating in a Salmonella study, and these included 19 farms with low prevalence of Salmonella (Martelli et al, 2017;Smith et al, 2017Smith et al, , 2018. Three additional farms were recruited solely for this study.…”

Section: Farm Recruitment and Samplingmentioning

confidence: 99%

Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain

et al. 2020

View full text Add to dashboard Cite

Combatting antimicrobial resistant (AMR) using a One-Health approach is essential as various bacteria, including Escherichia coli, a common bacteria, are becoming increasingly resistant and livestock may be a reservoir. The AMR gene content of 492 E. coli, isolated from 56 pig farms across Great Britain in 2014-2015, and purified on antibiotic selective and non-selective plates, was determined using whole genome sequencing (WGS). The E. coli were phylogenetically diverse harboring a variety of AMR profiles with widespread resistance to "old" antibiotics; isolates harbored up to seven plasmid Inc-types. None showed concurrent resistance to third-generation cephalosporins, fluoroquinolones and clinically relevant aminoglycosides, although ∼3% harbored AMR genes to both the former two. Transferable resistance to carbapenem and colistin were absent, and six of 117 E. coli STs belonged to major types associated with human disease. Prevalence of genotypically MDR E. coli, gathered from non-selective media was 46.9% and that of extended-spectrum-beta-lactamase E. coli was low (∼4% from non-selective). Approximately 72.6% of E. coli from ciprofloxacin plates and only 8.5% from the other plates harbored fluoroquinolone resistance due to topoisomerase mutations; the majority were MDR. In fact, multivariable analysis confirmed E. coli purified from CIP enrichment plates were more likely to be MDR, and suggested MDR isolates were also more probable from farms with high antibiotic usage, specialist finisher farms, and farms emptying their manure pits only after each batch. Additionally, farms from the South East were more likely to have MDR E. coli, whereas farms in Yorkshire and the Humber were less likely.

show abstract

Section: Farm Recruitment and Samplingmentioning

confidence: 99%

Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Increasing the quality of colostrum (i.e. the amount of immunoglobulins) through vaccination of pregnant sows before farrowing should be considered another potential strategy to protect suckling piglets from infection [43, 45–47] and even Salmonella shedding in older pigs [48, 49].…”

Section: Discussionmentioning

confidence: 99%

Weaned piglets: another factor to be considered for the control of Salmonella infection in breeding pig farms

Casanova-Higes

Marín-Alcalá

Andrés-Barranco

et al. 2019

Vet Res

View full text Add to dashboard Cite

Field studies on Salmonella infection in suckling piglets are scarce due to the intrinsic difficulties of collecting proper samples (i.e. tonsils or mesenteric lymph nodes), and most of them rely on the analysis of rectal swabs that limit their accuracy. We used 495 slaughtered 4-weeks-old male piglets intended for human consumption from 5 Salmonella -seropositive breeding farms to collect gastrointestinal packages and perform a thorough detection of Salmonella on mesenteric lymph nodes and intestinal content. The overall prevalence of both infection and shedding was high (≈ 36%) indicating that piglets played an active role in Salmonella maintenance in the farms. Major serotypes found in piglets included 4,[5],12:i: (35.4%), Rissen (17.1%), Derby (10.9%) and Bovismorbificans (10.3%). In most of the infected animals (72.8%) the same serotype was found in mesenteric lymph nodes and feces. Significant higher ELISA OD% values were found in meat juice samples from non-infected piglets compared to infected ones (median OD% of 12.0 and 17.3, respectively; P = 0.002) suggesting some protective effect of sow’s colostrum. Salmonella was also isolated from feces from weaned sows contemporary of the slaughtered piglets, and 89% of the serotypes identified in sows were also detected in piglets. Pulsed field gel electrophoresis analyses showed that 75% of the piglet isolates that were compared to those of sows were related to them, suggesting the circulation of Salmonella strains between sows and piglets. It appears that improving piglet colostrum intake along with the reduction of the shedding in sows may favor the control of Salmonella infection in breeding farms.

show abstract

“…Maternally derived immunity does not interfere with the effect of the vaccination of piglets, on the contrary, Rösler et al showed that vaccinated piglets from vaccinated sows had significantly lower infection levels after challenge than vaccinated piglets from unvaccinated sows [25]. The effectiveness of Salmoporc® is well documented [26][27][28][29] for the reduction of colonisation and shedding of Salmonella Typhimurium, sometimes even in the unvaccinated progeny of vaccinated sows [30,31]. However, to our knowledge, no studies exist that followed a vaccinated herd to the point where Salmonella Typhimurium could no longer be isolated from faecal and dust samples.…”

Section: Introductionmentioning

confidence: 99%

Salmonella Typhimurium environmental reduction in a farrow-to-finish pig herd using a live attenuated Salmonella Typhimurium vaccine

Wolf¹,

Meijerink²,

Libbrecht³

et al. 2021

Porc Health Manag

View full text Add to dashboard Cite

Background Salmonella Typhimurium is an important zoonotic pathogen in pigs, that can cause clinical disease. Many sow herds and finishing herds are infected with Salmonella, and therefore pose a threat for the contamination of pork and pork products and ultimately consumers. Case presentation This case study describes a farrow-to-finish pig herd, producing its own replacement gilts, which had experienced clinical outbreaks of salmonellosis since 2002. Outbreaks were characterised by profuse diarrhoea, dead pigs and high antimicrobial use (colistin sulphate). The aim of this study was to see whether using vaccination of sows and piglets with Salmoporc®, a live attenuated Salmonella Typhimurium vaccine, in combination with standard hygienic precautions, it was possible to reduce Salmonella Typhimurium to below the bacteriological detection limit. Monitoring of the presence of Salmonella was done using a total of 20 pooled faecal, sock and dust samples per herd visit in the period from September 2016 to October 2020. Within the first 10 months after the start of vaccination in August 2016, there was a rapid reduction in clinical symptoms, antimicrobial usage and the number of Salmonella-positive samples. During the winters of 2017/2018 and 2018/2019 the number of positive samples increased again, however with minimal need to use antimicrobials to treat the affected animals. In July 2019, only two samples from a corridor were positive. In September and November 2019 and in October 2020 all three samplings were completely negative for S. Typhimurium. Conclusions This case, together with other longitudinal studies, can be seen as a proof of the principle that long term vaccination with a live attenuated S. Typhimurium vaccine can reduce the level of S. Typhimurium in the herd environment to very low levels within a farrow-to-finish herd initially suffering from clinical salmonellosis. Also, clinical symptoms indicating salmonellosis were no longer observed and antimicrobials to treat clinically diseased pigs were no longer needed.

show abstract

Maternal vaccination as aSalmonellaTyphimurium reduction strategy on pig farms

Abstract: Aims: The control of Salmonella in pig production is necessary for public and animal health, and vaccination was evaluated as a strategy to decrease pig prevalence.

Cited by 19 publications

References 41 publications

Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain

Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain

Weaned piglets: another factor to be considered for the control of Salmonella infection in breeding pig farms

Salmonella Typhimurium environmental reduction in a farrow-to-finish pig herd using a live attenuated Salmonella Typhimurium vaccine

Contact Info

Product

Resources

About