Maternal vaccination against pertussis: a systematic review of the recent literature

Gkentzi, Despoina; Katsakiori, Paraskeui; Marangos, Markos; Hsia, Yingfen; Amirthalingam, Gayatri; Heath, Paul T; Ladhani, Shamez

doi:10.1136/archdischild-2016-312341

Cited by 92 publications

(68 citation statements)

References 62 publications

(46 reference statements)

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“…Pertussis vaccination in pregnancy may provide passive immunity to the infant via transplacental transfer of IgG, before primary immunisation 7273. Assure women that the vaccine is safe in pregnancy.…”

Section: How Can It Be Prevented?mentioning

confidence: 99%

Pertussis (whooping cough)

Gopal

Barber

Toeg³

2019

BMJ

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Section: How Can It Be Prevented?mentioning

confidence: 99%

Pertussis (whooping cough)

Gopal

Barber

Toeg³

2019

BMJ

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“…Despite the fact that both types of vaccines generate antibodies that impede bacterial adhesion and have bactericidal action, these have not been sufficient to halt the increase in the number of cases. In response to this increase a boost was introduced to extend immunological memory, and new vaccination strategies targeted to pregnant women and close family have also been introduced as an attempt to protect highly susceptible newborns (45)(46)(47)(48).…”

Section: The Bordetellae; Biology; and Experimental Systemmentioning

confidence: 99%

Immunomodulation as a Novel Strategy for Prevention and Treatment of Bordetella spp. Infections

2019

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Well-adapted pathogens have evolved to survive the many challenges of a robust immune response. Defending against all host antimicrobials simultaneously would be exceedingly difficult, if not impossible, so many co-evolved organisms utilize immunomodulatory tools to subvert, distract, and/or evade the host immune response. Bordetella spp. present many examples of the diversity of immunomodulators and an exceptional experimental system in which to study them. Recent advances in this experimental system suggest strategies for interventions that tweak immunity to disrupt bacterial immunomodulation, engaging more effective host immunity to better prevent and treat infections. Here we review advances in the understanding of respiratory pathogens, with special focus on Bordetella spp., and prospects for the use of immune-stimulatory interventions in the prevention and treatment of infection.

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“…Recent systematic reviews supported the safety, immunogenicity and effectiveness of maternal Tdap immunization to reduce the morbidity and mortality associated with pertussis in infants before they receive their primary immunizations [39,40]. Effectiveness against pertussis infection was 90-93% in infants aged <2 months [26,40]. Furthermore, a 51% relative reduction in pertussis cases has been observed in infants aged <2 months in Argentina in states with high Tdap vaccine coverage (>50%) compared to those with low coverage ( 50%) [41].…”

Section: Pertussismentioning

confidence: 99%

Section: Pertussismentioning

confidence: 99%

Maternal immunization: where are we now and how to move forward?

et al. 2018

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Pregnancy and the postpartum period are associated with elevated risks to both mother and infant from infectious disease. Vaccination of pregnant women, also called maternal immunization, has the potential to protect pregnant women, foetuses and infants from several vaccinepreventable diseases. Maternal immunoglobulin G antibodies are actively transferred through the placenta to provide passive immunity to new-borns during the first months of life, until the time for infant vaccinations or until the period of greatest susceptibility has passed. Currently, inactivated influenza, tetanus, and pertussis vaccines are recommended during pregnancy in many countries, but other vaccines may also be administered to pregnant women when risk factors are present. Several new vaccines with a specific indication for use during pregnancy are under development (e.g. respiratory syncytial virus and group B streptococcus vaccines). Years of experience suggest that maternal immunization against influenza, tetanus or pertussis has an acceptable safety profile, is well tolerated, effective and confers significant benefits to pregnant women and their infants. This review describes the principles of maternal immunization and provides an update of the recent evidence regarding the use and timing of maternal immunization. Finally, the barriers preventing wider vaccination coverage and the current limitations in addressing these are also described (Supplementary Material). KEY MESSAGESMaternal immunization gives pregnant women greater protection against infectious diseases; induces high levels of maternal antibodies that can be transferred to the foetus; and helps protect new-borns during their first months of life, until they are old enough to be vaccinated. Pregnant women and new-borns are more vulnerable to infectious diseases than the overall population; nevertheless, vaccination rates are often low in pregnant women. This review provides an update of the recent evidence regarding the use and timing of maternal immunization and describes the barriers preventing wider vaccination uptake and the current limitations in addressing these. ARTICLE HISTORY

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Maternal vaccination against pertussis: a systematic review of the recent literature

Cited by 92 publications

References 62 publications

Pertussis (whooping cough)

Pertussis (whooping cough)

Immunomodulation as a Novel Strategy for Prevention and Treatment of Bordetella spp. Infections

Maternal immunization: where are we now and how to move forward?

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