Maternal urinary bisphenol A levels and infant low birth weight: A nested case–control study of the Health Baby Cohort in China

Huo, Wenqian; Xia, Wei; Wan, Yanjian; Zhang, Bin; Zhou, Aifen; Zhang, Yiming; Huang, Kai; Zhu, Yaowu; Wu, Chuansha; Yang, Peng; Jiang, Minmin; Hu, Jie; Chang, Huailong; Xu, Bing; Li, Yuanyuan; Huo, Wenqian

doi:10.1016/j.envint.2015.09.005

Cited by 91 publications

(52 citation statements)

References 60 publications

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“…The evidence here is also conflicting. 10, 12, 13, 25, 48-50 Again, this may be due to suboptimal exposure assessment approaches. Two studies performed longitudinal analyses examining repeated urinary BPA concentrations as well as ultrasound scans to estimate the association with fetal growth.…”

Section: Discussionmentioning

confidence: 99%

“…3, 20-23 Longitudinal studies with repeated ultrasound measurements taken during gestation have greater power to detect effects. 24 Additionally, specific to these non-persistent chemicals, most studies utilize single spot urine concentrations of phthalate metabolite and BPA as indices of exposure; 10, 20, 22, 25, 26 however, due to their short half-lives in the human body, measurements may not be representative of exposure over the course of pregnancy. 27 In the present analysis we investigated longitudinal associations between maternal exposure to phthalates and BPA in pregnancy and fetal growth in women from a prospective birth cohort.…”

Section: Introductionmentioning

confidence: 99%

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Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth

Ferguson

Meeker

Cantonwine

et al. 2016

Environment International

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Growth of the fetus is highly sensitive to environmental perturbations, and disruption can lead to problems in pregnancy as well as later in life. This study investigates the relationship between maternal exposure to common plasticizers in pregnancy and fetal growth. Participants from a longitudinal birth cohort in Boston were recruited early in gestation and followed until delivery. Urine samples were collected at up to four time points and analyzed for concentrations of phthalate metabolites and bisphenol A (BPA). Ultrasound scans were performed at four time points during pregnancy for estimation of growth parameters, and birthweight was recorded at delivery. Growth measures were standardized to a larger population. For the present analysis we examined cross-sectional and repeated measures associations between exposure biomarkers and growth estimates in 482 non-anomalous singleton pregnancies. Cross-sectional associations between urinary phthalate metabolites or BPA and growth indices were imprecise. However, in repeated measures models, we observed significant inverse associations between di-2-ethylhexyl phthalate (DEHP) metabolites and estimated or actual fetal weight. An interquartile range increase in summed DEHP metabolites was associated with a 0.13 standard deviation decrease in estimated or actual fetal weight (95% confidence interval=−0.23, −0.03). Associations were consistent across different growth parameters (e.g., head circumference, femur length), and by fetal sex. No consistent associations were observed for other phthalate metabolites or BPA. Maternal exposure to DEHP during pregnancy was associated with decreased fetal growth, which could have repercussive effects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth

Ferguson

Meeker

Cantonwine

et al. 2016

Environment International

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“…BPA has also been shown to have weakly estrogenic properties (Centers for Disease Control and Prevention, 2015), and has been associated with changes in thyroid and reproductive hormone levels in animals (Peretz et al, 2014), elevated risks of low birth weight, smaller size for gestational age, preterm birth, as well as increases in the levels of leptin and adiponectin among male neonates (Cantonwine et al, 2015; Chou et al, 2011; Huo et al, 2015; Miao et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

Aker

Watkins

Johns

et al. 2016

Environmental Research

163

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Introduction Phenols and parabens are ubiquitous environmental contaminants. Evidence from animal studies and limited human data suggest they may be endocrine disruptors. In the current study, we examined associations of phenols and parabens with reproductive and thyroid hormones in 106 pregnant women recruited for the prospective cohort, “Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)”. Methods Urinary exposure biomarkers (bisphenol A, triclosan, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, butyl, methyl and propyl paraben) and serum hormone levels (estradiol, progesterone, sex hormone-binding globulin (SHBG), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone) were measured at up to two time points during pregnancy (16–20 weeks and 24–28 weeks). We used linear mixed models to assess relationships between exposure biomarkers and hormone levels across pregnancy, controlling for urinary specific gravity, maternal age, BMI and education. In sensitivity analyses, we evaluated cross-sectional relationships between exposure and hormone levels stratified by study visit using linear regression. Results An IQR increase in methyl paraben was associated with a 7.70% increase (95% CI 1.50, 13.90) in SHBG. Furthermore, an IQR increase in butyl paraben as associated with an 8.46% decrease (95% CI 16.92, 0.00) in estradiol, as well as a 9.34% decrease (95% CI −18.31, −0.38) in estradiol/progesterone. Conversely, an IQR increase in butyl paraben was associated with a 5.64% increase (95% CI 1.26, 10.02) in FT4. Progesterone was consistently negatively associated with phenols, but none reached statistical significance. After stratification, methyl and propyl paraben were suggestively negatively associated with estradiol at the first time point (16–20 weeks), and suggestively positively associated with estradiol at the second time point (24–28 weeks). Conclusions Within this ongoing birth cohort, certain phenols and parabens were associated with altered reproductive and thyroid hormone levels during pregnancy. These changes may contribute to adverse health effects in mothers or their offspring, but additional research is required.

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“…There is also evidence of a direct effect on the fetus, such as the HPA axis, thyroid receptors, and estrogen receptors [9,[23][24][25]. Moreover, BPA exposure in utero appears to be associated with implantation problems, as well as preeclampsia, preterm births, and low birth weight [26][27][28][29][30]. Indeed, fetal malformation was shown to be higher in offspring from mothers with higher levels of free circulating BPA levels [31], whilst there is a potential association between BPA exposure and low birth weight of infants, especially female [27].…”

Section: Introductionmentioning

confidence: 99%

Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation

Greca

Kyrou

Pink

et al. 2020

JCM

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Background: Endocrine-disrupting chemicals (EDCs) are environmental chemicals/toxicants that humans are exposed to, interfering with the action of multiple hormones. Bisphenol A (BPA) is classified as an EDC with xenoestrogenic activity with potentially adverse effects in reproduction. Currently, a significant knowledge gap remains regarding the complete spectrum of BPA-induced effects on the human placenta. As such, the present study examined the effects of physiologically relevant doses of BPA in vitro. Methods: qRT-PCR, Western blotting, immunofluorescence, ELISA, microarray analyses, and bioinformatics have been employed to study the effects of BPA using nonsyncytialised (non-ST) and syncytialised (ST) BeWo cells. Results: Treatment with 3 nM BPA led to an increase in cell number and altered the phosphorylation status of p38, an effect mediated primarily via the membrane-bound estrogen receptor (GPR30). Nonbiased microarray analysis identified 1195 and 477 genes that were differentially regulated in non-ST BeWo cells, whereas in ST BeWo cells, 309 and 158 genes had altered expression when treated with 3 and 10 nM, respectively. Enriched pathway analyses in non-ST BeWo identified a leptin and insulin overlap (3 nM), methylation pathways (10 nM), and differentiation of white and brown adipocytes (common). In the ST model, most significantly enriched were the nuclear factor erythroid 2-related factor 2 (NRF2) pathway (3 nM) and mir-124 predicted interactions with cell cycle and differentiation (10 nM). Conclusion: Collectively, our data offer a new insight regarding BPA effects at the placental level, and provide a potential link with metabolic changes that can have an impact on the developing fetus.

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Maternal urinary bisphenol A levels and infant low birth weight: A nested case–control study of the Health Baby Cohort in China

Cited by 91 publications

References 60 publications

Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth

Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth

Phenols and parabens in relation to reproductive and thyroid hormones in pregnant women

Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation

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