Maternal Treatment with Betamethasone (B) or TRH+B, Enhances Cardiovascular Function in Preterm Newborn Lambs

Moraga, F A; Riquelme, Raquel; Ríos, Antonio Limay; Navarrete, Cristina T.; Moya, F; Llanos, Aníbal J.

doi:10.1203/00006450-199602000-00030

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“…Potential explanations for the differences between preterm and full-term lambs may be similar to those discussed at length for HR. Also, the antenatal administration of betamethasone in preterm lambs, with or without TRH [26] , as discussed above for the HR response [9,16] , may have blunted the differences in MAP response to hypoxia between preterm and fullterm lambs. Finally, previous results question whether the simultaneous use of betamethasone, TRH, PGE 2 and oxytocin, all known to increase systemic arterial pressure, has contributed to enhancing cardiovascular adaptation in preterm lambs and blunting the negative effect of preterm birth on MAP response to hypoxia [27,28] .…”

Section: Effects Of Preterm Birth On Arterial Pressure Response To Hymentioning

confidence: 99%

Influence of Prematurity on Postnatal Maturation of Heart Rate and Arterial Pressure Responses to Hypoxia in Lambs

et al. 2007

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Background: While hypoxic events with bradycardias are a frequent occurrence during the first weeks of life in preterm infants, the impact of preterm birth on maturation of the cardiovascular response to hypoxia in early postnatal life is unknown. Objectives: In the present study, we tested the hypothesis that preterm birth influences postnatal maturation of cardiovascular responses to hypoxia. Methods: 6 preterm lambs (term 132 days, birth weight 2.9 kg) and 6 full-term lambs (term 147 days, birth weight 4.3 kg) were studied without sedation on days 3, 7, 14, 21 and 28 during acute, steady-state hypoxia (FIO₂ = 0.08, 15 min). Results: Results show that full-term lambs increased their heart rate (HR) in response to hypoxia from the first day of life, with no postnatal maturation thereafter. In preterm lambs, HR did not change before day 14 and the full-term-like response was not acquired before 2 weeks after theoretical term. In both groups, mean arterial pressure tended to decrease below baseline, but the amplitude of variations remained of small magnitude. Conclusion: The present results bring unique evidence that preterm birth is associated with a blunted heart response to steady-state hypoxia during the first postnatal week and a delay in the maturation of HR response.

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Section: Effects Of Preterm Birth On Arterial Pressure Response To Hymentioning

confidence: 99%

Influence of Prematurity on Postnatal Maturation of Heart Rate and Arterial Pressure Responses to Hypoxia in Lambs

et al. 2007

View full text Add to dashboard Cite

show abstract

Maternal Treatment with Betamethasone (B) or TRH+B, Enhances Cardiovascular Function in Preterm Newborn Lambs

Cited by 1 publication

References 0 publications

Influence of Prematurity on Postnatal Maturation of Heart Rate and Arterial Pressure Responses to Hypoxia in Lambs

Influence of Prematurity on Postnatal Maturation of Heart Rate and Arterial Pressure Responses to Hypoxia in Lambs

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