Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life

Aksu, İlkay; Baykara, Başak; Özbal, Seda; Çetin, Ferihan; Şişman, Ali Rιza; Dayı, Ayfer; Gençoğlu, Celal; Tas, Aysegul; Büyük, Erkan; Gonenc-Arda, Sevil; Uysal, Nazan

doi:10.1016/j.neulet.2012.03.091

Cited by 57 publications

(59 citation statements)

References 42 publications

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“…However, the results did not indicate any neuroprotective effects of the gestational exercise in the presence of additional stress factors, such as in the case of acute brain damage. The data obtained from open field test demonstrated an increased locomotor activity, mobility duration and distance travelled in offspring of exercise mothers compared to the offspring of sedentary mothers [9]. However, our results did not show such an effect.…”

Section: Discussioncontrasting

confidence: 86%

“…Therefore, this suggests that gestational exercise in a brain injury model does not have any protective effects. On the contrary, the offspring of mothers forced to exercise during gestation demonstrated an increased entry to the open arms in elevated plus maze test indication a reduced anxiety behavior [9]. LPS treatment has been previously shown to decrease the social behaviors, however, no effects has been reported on elevated plus maze test [10].…”

Section: Discussionmentioning

confidence: 91%

“…LPS treatment during critical stages of embryonic development has been shown to cause reduced adult hippocampal neurogenesis and BDNF levels, increased tendency of depressive behavior and long-term behavioral changes in adults [11]. Previously publish studies in the literature demonstrates an increased BDNF and VEGF levels in the brain and improved open field and locomotor activity test results from offspring of exercised mothers during pregnancy [5,9,[12][13][14]. Therefore, it is expected to observe an increased tolerance to the brain damage through endogenous trophic factors, such as BDNF.…”

Section: Discussionmentioning

confidence: 99%

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Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Dilek

Orallar

Bozat

et al. 2018

j-ebr

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A B S T R A C T Aim:The effects of gestational exercise on potential pathological conditions is not known yet. Therefore, in the present study, it was aimed to evaluate the effects of forced running exercise on lipopolysaccharide (LPS)-induced brain damage in pregnant rats. Method: Pregnant females in the experimental group were forced to exercise 30 minutes daily for five days a week. Lipopolysaccharide (LPS)-induced brain injury model was created by administering 500 µg/kg body weight of LPS on gestational days 18 and 19. To evaluate injury histopathologically, brain tissues were fixed at the seventh postnatal day through transcardial perfusion (n=4 pups/group). When the remaining pups reached 30-day of age, Morris water maze test (MWM) was performed to assess memory and learning, open filed (OP) and elevated plus maze (EPM) for testing anxiety, and Porsolt test (PT) for evaluating depression. The groups were defined as brain injury group (BI, n=13) and exercise+brain injury group (E+BI, n=7). Results: The results obtained from MWM test indicated that animals found the platform in a shorter duration and distance at the day five compared to the day three. However, there was no significant difference between the groups. No significant difference was found in OP test regarding the distance traveled, time spent at the margins, movement at the center and the time spent as immobile. However, in the EPM test, the offspring at the BI group displayed higher mobility and increased number of entry to the open arms compared to the E+BI groups (p=0.01). There was no significant difference regarding mobility duration and total distance traveled in the PT test. Conclusion:The results of the EPM test suggests that the gestational exercise can suppress the stress factors in the pregnant females with brain injury leading to the prevention of hyperactivity-induced negative learning behavior.

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Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Dilek

Orallar

Bozat

et al. 2018

j-ebr

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“…The direct or indirect action of the venom would be responsible for injuries in the formation of motor pathways or, alternatively, for an unbalance in the release of important neurotransmitters, such as dopamine, which is critical for the control of the motor activity [63, 65]. Females are more susceptible to prenatal stress [66].…”

Section: Effects Of Envenomation During Pregnancy On Postnatal Develomentioning

confidence: 99%

Perinatal effects of scorpion venoms: maternal and offspring development

Dorce

Martins

Dorce

et al. 2017

J Venom Anim Toxins Incl Trop Dis

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Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possible victims. Scorpion stings alter the release of neurotransmitters and some cytokines. These mediators act as organizers and programmers in the adequate formation of the nerves, and non-physiological concentrations of them during the brain organization originate disorders and diseases that can appear later in the life of the individual. Despite the importance of this subject, there are only a few studies showing the effects of scorpion venom on maternal reproductive development, in the morphology and physical and behavioral development of offspring. The present review article summarizes the major findings on this issue. Biochemical changes in the blood – such as hyperglycemia, increase on the level of sodium and on the creatinine concentration – are observed after scorpion sting in humans and experimental animals. Some studies in the literature demonstrate that the scorpion venom affects the maternal reproductive development in humans and in experimental animals, increasing the frequency and amplitude of uterine contraction and the number of resorptions. The venom can also lead to some alterations in the embryonic or fetal development increasing the total weight of fetuses and of some organs. Moreover, it affects the general activity and locomotion during childhood and adulthood, and the anxiety level in adult females and males. It also alters the number of hippocampal neurons and interferes in the level of some cytokines. Altogether, it is evident that the venom, when administered during the pregnancy or lactation, affects the development of the offspring. Studies are being conducted to determine the actual participation of the venom in the development of the offspring, and to what extent they are detrimental to animal development.

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“…In humans, participation in physical activity not only improves learning and memory (Colcombe et al, 2004) but is also argued to slow the progress of neurodegenerative diseases such as Alzheimer’s disease (Nelson & Tabet, 2015). Further, work with rodents has demonstrated increased levels of neurotrophic factors such as BDNF and VEGF in the cortex following voluntary exercise (Hopkins et al, 2011, Uysal et al, 2011, Aksu et al, 2012). These factors promote the differentiation, neurite extension, and survival of a variety of neuronal populations (Cotman and Berchtold, 2002).…”

mentioning

confidence: 99%

Neonatal alcohol exposure reduces number of parvalbumin-positive interneurons in the medial prefrontal cortex and impairs passive avoidance acquisition in mice deficits not rescued from exercise

et al. 2017

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Developmental alcohol exposure causes a host of cognitive and neuroanatomical abnormalities, one of which is impaired executive functioning resulting from medial prefrontal cortex (mPFC) damage. This study determined whether third-trimester equivalent alcohol exposure reduced the number of mPFC GABAergic parvalbumin-positive (PV+) interneurons, hypothesized to play an important role in local inhibition of the mPFC. The impact on passive avoidance learning and the therapeutic role of aerobic exercise in adulthood was also explored. Male C57BL/6J mice received either saline or 5 g/kg ethanol (two doses, two hours apart) on PD5, 7, and 9. On PD35, animals received a running wheel or remained sedentary for 48 days before behavioral testing and perfusion on PD83. The number of PV+ interneurons was stereologically measured in three separate mPFC subregions: infralimbic, prelimbic and anterior cingulate cortices (ACC). Neonatal alcohol exposure decreased number of PV+ interneurons and volume of the ACC, but the other regions of the mPFC were spared. Alcohol impaired acquisition, but not retrieval of passive avoidance, and had no effect on motor performance on the rotarod. Exercise had no impact on PV+ cell number, mPFC volume, or acquisition of passive avoidance, but enhanced retrieval in both control and alcohol-exposed groups, and enhanced rotarod performance in the control mice. Results support the hypothesis that part of the behavioral deficits associated with developmental alcohol exposure are due to reduced PV+ interneurons in the ACC, but unfortunately exercise does not appear to be able to reverse any of these deficits.

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Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life

Cited by 57 publications

References 42 publications

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Can gestational exercise have a positive effect on cognitive functions resulting from brain injury A rat study

Perinatal effects of scorpion venoms: maternal and offspring development

Neonatal alcohol exposure reduces number of parvalbumin-positive interneurons in the medial prefrontal cortex and impairs passive avoidance acquisition in mice deficits not rescued from exercise

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