Maternal transmission risk and antibody levels against hepatitis B virus e antigen in pregnant women

Lu, Lingling; Chen, Bing-Xiang; Wang, Jiandong; Wang, Dongmei; Ji, Yue; Yi, Hong-Gan; Chen, Taoyang; Zhang, Yue; Petersen, Eskild; Li, Qin; Qu, Chunfeng

doi:10.1016/j.ijid.2014.07.028

Cited by 16 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We identified 346 unique papers after searching PubMed and Web of Science. Of these, 21 publications with 10 142 mother–child pairs were eligible for the evaluation of the relationship of maternal viral load and HBV MTCT risk. Figure shows the stages in identifying studies for inclusion in the review.…”

Section: Resultsmentioning

confidence: 99%

Maternal viral load and hepatitis B virus mother‐to‐child transmission risk: A systematic review and meta‐analysis

Chen

Zha

Cai

et al. 2018

Hepatology Research

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Maternal viral load and hepatitis B virus mother‐to‐child transmission risk: A systematic review and meta‐analysis

Chen

Zha

Cai

et al. 2018

Hepatology Research

View full text Add to dashboard Cite

show abstract

“…Similarly, high maternal viral load at the time of delivery was correlated with VT 11,12,15,16,26,28. Several studies quantified viral loads above which there was increased risk, but the results ranged from 10 5 –10 8 copies/mL 1,15,16,19,26,28,29.…”

Section: Hbvmentioning

confidence: 99%

“…Several studies quantified viral loads above which there was increased risk, but the results ranged from 10 5 –10 8 copies/mL 1,15,16,19,26,28,29. Gentile et al 1.…”

Section: Hbvmentioning

confidence: 99%

Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis

Mavilia¹,

Wu²

2017

Journal of Clinical and Translational Hepatology

View full text Add to dashboard Cite

Vertical transmission (VT) is the primary route of transmission of viral hepatitis in children. The rate of VT ranges from 1–28% with hepatitis B virus (HBV) and 3–15% with hepatitis C virus (HCV). VT for both viruses can occur during the intrauterine or peripartum period. VT of HBV primarily occurs by intrauterine transmission (IUT). Hepatitis B surface antigen is unable to cross the placenta and, therefore, relies on processes like transplacental leakage, placental infection, cellular transmission by peripheral blood mononuclear cells, and germline transmission. HCV can also infect the fetus by IUT. Both viruses also have the potential for transmission during delivery, when there is increase chance of maternal–fetal blood exposure. HBV and HCV share some common risk factors for VT, including maternal viral load, human immunodeficiency virus co-infection and neonatal sex. Prevention of VT differs greatly between HBV and HCV. There are several alternatives for prevention of HBV VT, including antiviral medications during the third trimester of pregnancy and HBV vaccine, as well as hepatitis B immunoglobulin administration to infants post-partum. In contrast, there are no preventative interventions available for HCV. Despite these differences, the key to prevention with both viruses is screening women prior to and during pregnancy.

show abstract

“…1 Vertical (mother-to-child) transmission of HBV occurs via exposure to infected blood and body fluids during delivery, and is strongly associated with the maternal viral load (measured as the concentration of HBV DNA) and the presence of the HBV e antigen. 2 As the likelihood of chronic HBV infection is inversely related to age at the time of exposure, it is crucial that steps are taken to prevent vertical transmission.…”

Section: Introductionmentioning

confidence: 99%

A decision analytic model for prevention of hepatitis B virus infection in Sub‐Saharan Africa using birth‐dose vaccination

Anderson

Dionne-Odom

Halle-Ekane

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

Maternal transmission risk and antibody levels against hepatitis B virus e antigen in pregnant women

Abstract: The presence of maternal anti-HBe is protective against HBV MTCT, independent of the maternal serum HBV viral load.

Cited by 16 publications

References 27 publications

Maternal viral load and hepatitis B virus mother‐to‐child transmission risk: A systematic review and meta‐analysis

Maternal viral load and hepatitis B virus mother‐to‐child transmission risk: A systematic review and meta‐analysis

Mechanisms and Prevention of Vertical Transmission in Chronic Viral Hepatitis

A decision analytic model for prevention of hepatitis B virus infection in Sub‐Saharan Africa using birth‐dose vaccination

Contact Info

Product

Resources

About