Maternal thrombocytopenia in pregnancy

Perepu, Usha; Rosenstein, Lori J.

doi:10.17077/2154-4751.1193

Cited by 20 publications

(23 citation statements)

References 37 publications

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“…6 In first and second trimester, significantly decreased platelet count is more likely to be due to an immune process or rarely a platelet production deficit. In GT, there is no past history suggestive of thrombocytopenia and women are typically asymptomatic in early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Thrombocytopenia in pregnancy in a tertiary care hospital: a retrospective study

Varghese

Kour

Dhar

2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionmentioning

confidence: 99%

Thrombocytopenia in pregnancy in a tertiary care hospital: a retrospective study

Varghese

Kour

Dhar

2016

Int J Reprod Contracept Obstet Gynecol

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“…1,5,6,11 There were two (2%) maternal deaths in our study as compared to Nisha S 2 et al and Usha et al 11 where they reported 5.26% and 4.37% maternal mortality . One death was due to AFLP and another one was due to APLA.…”

Section: Fig 1: Severity Of Thrombocytopenia According To Etiologiesmentioning

confidence: 38%

“…Thrombocytopenia complicates 7 to 10% of all pregnancies. 1 The normal range of platelets in non-pregnant women is 150,000-400,000/µ L. Average platelet count in pregnancy is decreased 180,000-213,000 versus 250,000/µL. 2 Classification of thrombocytopenia in pregnancy is similar to non-pregnant patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

2020

IJOGR

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Introduction: Thrombocytopenia can result from a wide range of conditions with several of them being pregnancy related. Obstetricians manage most cases of pregnancy-associated thrombocytopenia. Thus, a working knowledge of the clinical features and management of thrombocytopenia in pregnant women is important. The objective of the study was to evaluate the causes of thrombocytopenia and its effect on maternal and neonatal outcome in parturient women and also evaluate the obstetric risk factors, complications, and outcome of pregnancies complicated by thrombocytopenia. Materials and Methods: A prospective study of 100 antenatal women with thrombocytopenia who delivered at St John's Medical College Hospital during a one and a half year period. The blood samples of pregnant women in labor room were collected at the time of admission. These women were followed up till they deliver. Results:The main causes of thrombocytopenia were hypertensive disorders: preeclampsia (15%), Hemolysis, elevated liver enzymes, and low platelets (24%) and eclampsia (4%); idiopathic thrombocytopenic purpura (16%), gestational thrombocytopenia (11%). Women with hypertensive disorders had higher rates of cesarean delivery (65%), intrauterine growth restriction (30%) and preterm deliveries (31%). Hemorrhagic complications are common in rarer causes of thrombocytopenia. Conclusion:The adverse outcome is specifically attributed to preeclampsia, HELLP syndrome and rare causes. While the perinatal outcome of GT and ITP is basically favorable. Careful surveillance is required for these women in high-risk units for early detection and treatment of possible complications, in order to reduce adverse maternal and neonatal outcomes.

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“…2 Both patients with ITP were diagnosed during the prepregnancy period. 4 An entire placenta was available from all 10 patients and were fixed in 10% formalin. Placentas were weighed after the membranes and umbilical cord were trimmed off and compared with the reference weights for trimmed singleton placentas.…”

Section: According To the Revised Sydney Classification Criteria Aplmentioning

confidence: 99%

Placental pathology in maternal autoimmune diseases-new insights and clinical implications

Ramya

Umamaheswari

Chaitra

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Pregnancy in women with autoimmune diseases is frequently associated with placental insufficiency leading to adverse perinatal outcome. Aim of the study was to investigate the presence and possible clinical significance of placental lesions in mothers with different autoimmune disorders.Methods: In this retrospective study, 11 placentas from 10 mothers with diverse autoimmune diseases including systemic lupus Erythematosus (SLE), antiphospholipid antibodies (APLA), idiopathic thrombocytopenic purpura (ITP) and antinuclear antibodies (ANA) were studied.Results: Placental correlates were reduced placental weight, maternal vascular under perfusion, abruption, villitis of unknown etiology, multifocal chorangiomatosis, distal villous immaturity, massive perivillous fibrin deposition/maternal floor infarction and foetal thrombotic vasculopathy. Of the 11 pregnancies 3 were untreated (1 SLE, 2 APLA) and resulted in intrauterine foetal demise. The lesions were more severe in these cases. All the treated pregnancies resulted in live born babies (8), of which 3 were growth restricted, 2 were complicated with oligohydramnios and 3 were delivered preterm.Conclusions: In this group of diverse autoimmune disorders, placental lesions were not specific for each of them. Apart from maternal vascular under perfusion, lesions like villitis of unknown etiology, distal villous immaturity and massive perivillous fibrin deposition were identified and may recur in subsequent pregnancies and treatment should be directed towards modifying it. The placental examination should be mandatory in all cases of maternal autoimmunity and pregnancies with poor foetal outcome.

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Maternal thrombocytopenia in pregnancy

Cited by 20 publications

References 37 publications

Thrombocytopenia in pregnancy in a tertiary care hospital: a retrospective study

Thrombocytopenia in pregnancy in a tertiary care hospital: a retrospective study

Prevalence of thrombocytopenia in Parturient: Experience in Tertiary Care Center

Placental pathology in maternal autoimmune diseases-new insights and clinical implications

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