Maternal Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Risk for Autism Spectrum Disorders in Offspring: A Meta-analysis

Zhu, Zhanyong; Tang, Shiming; Deng, Xiaopeng; Wang, Ying

doi:10.1007/s10803-020-04400-y

Cited by 25 publications

(31 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I found self-emerging clusters that clearly (and automatically) differentiated neuropsychiatric and neurological disorders from non-neurological diseases and within the brain-related disorders, I established an orderly distance to Autism in the sense of overlapping genes and their expression on tissues critical for motor control (initiaself-regulation. I also found that the autoimmune disorder lupus systemic shares 114 genes with those linked to Autism in SFARI (12.6% relative to the 906 genes in SFARI), a result congruent with recent links between Autism and autoimmune disorders[58,59,63].The overall conclusions from these results are several folds: (1) Autism is a movement disorder and should be accordingly redefined and treated as such, rather than treated as a misbehavior; (2) The broad spectrum of Autism, as we know it today, i.e., inclusive of disorders and diseases of known etiology, share a common set of genes with genetic disorders and consequentially can be stratified into Autism subtypes. (3) Given this automatic clustering, it is safe to conclude that Autism prevalence rates are an artifact of current surveillance methods relying exclusively on the clinical (behavioral) diagnosis that welcomes other disorders.…”

supporting

confidence: 79%

“…Interestingly, I included PTSD owing to the tendency of trauma reported in Autism [51,56,57] and found 55 genes of those linked to PTSD in the SFARI-Autism set. I also included lupus systemic, owing to the known relations between autism and autoimmune disorders [58,59]. Likewise, quantification of genes linked to well-known neurological disorders and present in the SFARI-Autism dataset yielded up to 164 overlapping genes.…”

Section: Neuropsychiatric Disorders and Autism Share Common Genes Expressed In Brain Tissuesmentioning

confidence: 99%

See 1 more Smart Citation

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify its “Epidemic Rates”

Torres

2021

Preprint

View full text Add to dashboard Cite

In the last decade, Autism has broadened and often shifted its diagnostics criteria, allowing several neuropsychiatric and neurological disorders of known etiology. This has resulted in a highly heterogeneous spectrum with apparent exponential rates in prevalence. We ask if it is possible to leverage existing genetic information about those disorders making up Autism today and use it to stratify this spectrum. To that end, we combine genes linked to Autism in the SFARI database and genomic information from the DisGeNet portal on 25 diseases, inclusive of non-neurological ones. We use the GTEx data on genes' expression on 54 human tissues and ask if there are overlapping genes across those associated to these diseases and those from Autism-SFARI. We find a compact set of genes across all brain-disorders which express highly in tissues fundamental for somatic-sensory-motor function, self-regulation, memory, and cognition. Then, we offer a new stratification that provides a distance-based orderly clustering into possible Autism subtypes, amenable to design personalized targeted therapies within the framework of Precision Medicine. We conclude that viewing Autism through this physiological (Precision) lens, rather than from a psychological behavioral construct, may make it a more manageable condition and dispel the Autism epidemic myth.

show abstract

supporting

confidence: 79%

Section: Neuropsychiatric Disorders and Autism Share Common Genes Expressed In Brain Tissuesmentioning

confidence: 99%

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify its “Epidemic Rates”

Torres

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Maternal autoimmune disease during pregnancy, including thyroid disease and rheumatoid arthritis, was found to be an independent risk factor for ASD in offspring 30,31 . However, the 6 identified studies investigating the association between maternal asthma with ASD in offspring have produced mixed results [32][33][34][35][36][37] .…”

Section: Resultsmentioning

confidence: 97%

Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review

et al. 2021

View full text Add to dashboard Cite

Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), triggered by both acute and systemic chronic inflammation, is hypothesized to be one of the mechanisms implicated in the pathogenesis of neurodevelopmental disorders (NDD). Although there is substantial preclinical evidence to support the MIA hypothesis, the human evidence is disparate. We performed a systematic review on human studies examining associations between maternal inflammatory states and offspring NDDs (autism spectrum disorder- ASD, attention deficit hyperactivity disorder-ADHD, Tourette syndrome-TS). 32 meta-analyses and 26 additional individual studies were identified. Maternal states associated with ASD include obesity, gestational diabetes mellitus, pre-eclampsia, pollution, stress, depression, autoimmune diseases, and infection. Maternal states associated with ADHD include obesity, pre-eclampsia, smoking, low socioeconomic status (SES), stress, autoimmune disease, and asthma. Maternal states associated with TS include low SES, depression, and autoimmune diseases. Diverse maternal inflammatory states in pregnancy are associated with common offspring NDDs. Given the increased prevalence of NDDs, there is urgent need to explore relative and cumulative maternal risk factors and disease mechanisms. Defining preventable risk factors in high-risk pregnancies could mitigate the expression and severity of NDDs.

show abstract

“…Interestingly, I included PTSD owing to the tendency of trauma reported in Autism [49,54,55] and found 55 genes of those linked to PTSD in the SFARI-Autism set. I also included lupus systemic, owing to the known relations between autism and autoimmune disorders [56,57].…”

Section: Neuropsychiatric Disorders and Autism Share Common Genes Expressed In Brain Tissues For Motor Emotional And Self-regulatory Contmentioning

confidence: 99%

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”

Torres

2021

JPM

View full text Add to dashboard Cite

In the last decade, Autism has broadened and often shifted its diagnostics criteria, allowing several neuropsychiatric and neurological disorders of known etiology. This has resulted in a highly heterogeneous spectrum with apparent exponential rates in prevalence. I ask if it is possible to leverage existing genetic information about those disorders making up Autism today and use it to stratify this spectrum. To that end, I combine genes linked to Autism in the SFARI database and genomic information from the DisGeNET portal on 25 diseases, inclusive of non-neurological ones. I use the GTEx data on genes’ expression on 54 human tissues and ask if there are overlapping genes across those associated to these diseases and those from SFARI-Autism. I find a compact set of genes across all brain-disorders which express highly in tissues fundamental for somatic-sensory-motor function, self-regulation, memory, and cognition. Then, I offer a new stratification that provides a distance-based orderly clustering into possible Autism subtypes, amenable to design personalized targeted therapies within the framework of Precision Medicine. I conclude that viewing Autism through this physiological (Precision) lens, rather than viewing it exclusively from a psychological behavioral construct, may make it a more manageable condition and dispel the Autism epidemic myth.

show abstract

Maternal Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Risk for Autism Spectrum Disorders in Offspring: A Meta-analysis

Cited by 25 publications

References 47 publications

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify its “Epidemic Rates”

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify its “Epidemic Rates”

Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review

Precision Autism: Genomic Stratification of Disorders Making Up the Broad Spectrum May Demystify Its “Epidemic Rates”

Contact Info

Product

Resources

About