Maternal supplementation with human milk-derived <i>Lactiplantibacillus plantarum</i> WLPL04 affects the immunity and gut microbiota of offspring rats

Zhong, Changcheng; Wang, Qianhui; He, Yao; Zhao, Xiangxiang; Wang, Yanghong; Li, He; Wei, Hua; Tao, Xue Ying

doi:10.1039/d3fo00626c

Cited by 1 publication

(1 citation statement)

References 73 publications

(87 reference statements)

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“…Certain microbial organisms in the intestines of offspring have been implicated in shaping the immune response. For instance, maternal intake of human milk-derived Lactiplantibacillus plantarum during lactation increased the levels of intestinal Bacteroides in offspring early in life, along with elevated serum levels of IL-6 and increased splenic CD4 + T lymphocytes [59]. Newborn mice from mothers supplemented with butyrate showed an enrichment of fecal microbial signatures of Bacteroidetes and Clostridia, which are linked to the prevention of hepatic immune cell activation [60].…”

Section: Microbial Compositionmentioning

confidence: 99%

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

Tzeng,

Lee

2024

Nutrients

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Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent pediatric liver disorder, primarily attributed to dietary shifts in recent years. NAFLD is characterized by the accumulation of lipid species in hepatocytes, leading to liver inflammation that can progress to steatohepatitis, fibrosis, and cirrhosis. Risk factors contributing to NAFLD encompass genetic variations and metabolic disorders such as obesity, diabetes, and insulin resistance. Moreover, transgenerational influences, resulting in an imbalance of gut microbial composition, epigenetic modifications, and dysregulated hepatic immune responses in offspring, play a pivotal role in pediatric NAFLD development. Maternal nutrition shapes the profile of microbiota-derived metabolites in offspring, exerting significant influence on immune system regulation and the development of metabolic syndrome in offspring. In this review, we summarize recent evidence elucidating the intricate interplay between gut microbiota, epigenetics, and immunity in fetuses exposed to maternal nutrition, and its impact on the onset of NAFLD in offspring. Furthermore, potential therapeutic strategies targeting this network are also discussed.

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Section: Microbial Compositionmentioning

confidence: 99%

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

Tzeng,

Lee

2024

Nutrients

View full text Add to dashboard Cite

show abstract

Maternal supplementation with human milk-derived Lactiplantibacillus plantarum WLPL04 affects the immunity and gut microbiota of offspring rats

Abstract: Pregnancy and lactation are window period during which the interventions on mothers bring beneficial effects to newborns. This study is aiming to investigate the effects of maternal supplementation of a...

Cited by 1 publication

References 73 publications

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

Impact of Transgenerational Nutrition on Nonalcoholic Fatty Liver Disease Development: Interplay between Gut Microbiota, Epigenetics and Immunity

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