Maternal supplementation with glycerol monolaurate improves the intestinal health of suckling piglets by inhibiting the NF-κB/MAPK pathways and improving oxidative stability

Zhao, Hao; Tian, Min; Xiong, Liang; Lin, Tongbin; Zhang, Shuchang; Yue, Xianhuai; Liu, Xinghong; Chen, Fang; Zhang, Shihai; Guan, Wutai

doi:10.1039/d3fo00068k

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Glycerol monolaurate (GML) exhibits potent antimicrobial, antiviral, and anti-inflammatory properties, effectively enhancing animal resistance to infections, immunity, and overall health [16]. Research conducted in sows has revealed that both Se and GML could enhance the redox balance, resulting in improved pregnancy outcomes by mitigating risks, such as intrauterine growth restriction, abortion, and infections [17][18][19][20]. Accumulating evidence demonstrates that the gut microbiota composition undergoes modification and reshaping in animals supplemented with Se and GML, implying that the gut microbiota could potentially function as a beneficial mechanism for enhancing reproductive health [21,22].…”

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confidence: 99%

Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut–Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy

Zhang,

Wang,

et al. 2024

Antioxidants

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This study aims to investigate the impact of dietary supplementation with selenium yeast (SeY) and glycerol monolaurate (GML) on the transfer of antioxidative capacity between the mother and fetus during pregnancy and its underlying mechanisms. A total of 160 sows with similar body weight and parity of 3–6 parity sows were randomly and uniformly allocated to four groups (n = 40) as follows: CON group, SeY group, GML group, and SG (SeY + GML) group. Animal feeding started from the 85th day of gestation and continued to the day of delivery. The supplementation of SeY and GML resulted in increased placental weight and reduced lipopolysaccharide (LPS) levels in sow plasma, placental tissues, and piglet plasma. Furthermore, the redox balance and inflammatory markers exhibited significant improvements in the plasma of sows fed with either SeY or GML, as well as in their offspring. Moreover, the addition of SeY and GML activated the Nrf2 signaling pathway, while downregulating the expression of pro-inflammatory genes and proteins associated with inflammatory pathways (MAPK and NF-κB). Vascular angiogenesis and nutrient transportation (amino acids, fatty acids, and glucose) were upregulated, whereas apoptosis signaling pathways within the placenta were downregulated with the supplementation of SeY and GML. The integrity of the intestinal and placental barriers significantly improved, as indicated by the increased expression of ZO-1, occludin, and claudin-1, along with reduced levels of DLA and DAO with dietary treatment. Moreover, supplementation of SeY and GML increased the abundance of Christensenellaceae_R-7_group, Clostridium_sensus_stricto_1, and Bacteroidota, while decreasing levels of gut microbiota metabolites LPS and trimethylamine N-oxide. Correlation analysis demonstrated a significant negative relationship between plasma LPS levels and placental weight, oxidative stress, and inflammation. In summary, dietary supplementation of SeY and GML enhanced the transfer of antioxidative capacity between maternal-fetal during pregnancy via gut–placenta axis through modulating sow microbiota composition.

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Section: Introductionmentioning

confidence: 99%

Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut–Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy

Zhang,

Wang,

et al. 2024

Antioxidants

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α-Lipoic acid improves mitochondrial biogenesis and dynamics by enhancing antioxidant and inhibiting Wnt/Ca2+ pathway to relieve fluoride-induced hepatotoxic injury

Yu,

Xu,

et al. 2023

Chemico-Biological Interactions

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A comprehensive review of medium chain monoglycerides on metabolic pathways, nutritional and functional properties, nanotechnology formulations and applications in food system

Yang,

Zhang,

Yan

et al. 2024

Critical Reviews in Food Science and Nutrition

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Maternal supplementation with glycerol monolaurate improves the intestinal health of suckling piglets by inhibiting the NF-κB/MAPK pathways and improving oxidative stability

Abstract: Maternal diet supplemented with 0.1% GML enhanced offspring intestinal oxidative homeostasis and barrier function, and attenuated offspring intestinal inflammatory response possibly through suppressing the activation of the NF-κB/MAPK pathways.

Cited by 4 publications

References 45 publications

Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut–Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy

Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut–Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy

α-Lipoic acid improves mitochondrial biogenesis and dynamics by enhancing antioxidant and inhibiting Wnt/Ca2+ pathway to relieve fluoride-induced hepatotoxic injury

A comprehensive review of medium chain monoglycerides on metabolic pathways, nutritional and functional properties, nanotechnology formulations and applications in food system

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