Maternal Supplementation With Avocado (Persea americana Mill.) Pulp and Oil Alters Reflex Maturation, Physical Development, and Offspring Memory in Rats

Melo, Marília Ferreira Frazão Tavares de; Pereira, Diego Elias; Moura, Renally de Lima; Silva, Elisiane Beatriz da; Melo, Flávio Augusto Lyra Tavares de; Dias, Celina de Castro Querino; Alves, Maciel da Costa; Oliveira, Maria Elieidy Gomes de; Viera, Vanessa Bordin; Pintado, Manuela; Santos, Sócrates Golzio dos; Soares, Juliana Késsia Barbosa

doi:10.3389/fnins.2019.00009

Cited by 25 publications

(12 citation statements)

References 94 publications

(126 reference statements)

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“…Compared to other vegetable oils, avocado oils are high in MUFA (oleic and palmitoleic acids) and low in polyunsaturated fatty acids (linoleic acid and linolenic acid) [3]. Oleic acid is the principal fatty acid in avocado, comprising 45% of its total fatty acids [69], and during the ripening process, palmitic acid content decreases and oleic acid content increases [70]. In terms of its total fat content and fatty acid composition, avocado oil is considered to be similar to olive oil [71].…”

Section: Introductionmentioning

confidence: 99%

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

et al. 2019

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Persea americana, commonly known as avocado, has recently gained substantial popularity and is often marketed as a “superfood” because of its unique nutritional composition, antioxidant content, and biochemical profile. However, the term “superfood” can be vague and misleading, as it is often associated with unrealistic health claims. This review draws a comprehensive summary and assessment of research performed in the last few decades to understand the nutritional and therapeutic properties of avocado and its bioactive compounds. In particular, studies reporting the major metabolites of avocado, their antioxidant as well as bioavailability and pharmacokinetic properties, are summarized and assessed. Furthermore, the potential of avocado in novel drug discovery for the prevention and treatment of cancer, microbial, inflammatory, diabetes, and cardiovascular diseases is highlighted. This review also proposes several interesting future directions for avocado research.

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Section: Introductionmentioning

confidence: 99%

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

et al. 2019

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“…In addition, it closely resembles olive oil because it is extracted pulp and the similarity of their properties is mainly due to the composition of their fatty acids, which is predominantly oleic acid in both (Flores et al, 2019). However, unlike olive oil, which has been extensively studied for its neuroprotective properties (Angeloni et al, 2017), investigations into the effects of AO on neural function are still quite incipient (De Mello et al, 2019;Nam et al, 2019;Ortiz-Avila et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Omega-3 and omega-6 polyunsaturated and omega-9 monoun- Therefore, foods rich in unsaturated fatty acids and other bioactive molecules could attenuate the negative effects of chronic cortisol exposure. This is the case of avocado oil (AO), which contains a wide variety of lipids that are mainly composed of triacylglycerols, such as monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids (De Mello et al, 2019). Previous evidence has described the beneficial effects of AO on neural development and functions (Flores et al, 2019;Bhuvan et al, 2019;Ortega-Arellano et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Avocado oil ( Persea americana ) protects SH‐SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules

et al. 2021

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Chronic psycho-environmental stress can induce neurological dysfunction due to an increase in cortisol levels. It is possible that some food supplements could attenuate its negative impact, such as avocado oil (AO), which is rich in fatty acids with beneficial effects on the brain. This hypothesis was tested by an in vitro model using undifferentiated neuroblastoma cells (SH-SY5Y) exposed to hydrocortisone (HC), an active cortisol molecule with and without AO-supplementation. Cortisol can induce oxidative stress, apoptosis events, and a lowering effect on brain-derived neurotrophic factor (BDNF), a neurogenic molecule. As AO protective effects on HC-exposed cells could involve these routes, some markers of these routes were compared among neuroblastoma cultures. In the first assay, the range concentrations of HC exposure that trigger cell mortality and range AO-concentrations that could revert the HC effect. AO at all concentrations tested (2-30 µg/ml) did not present a cytotoxic effect on SH-SY5Y cells, whereas HC at 0.3-10 ng/ml had a dose-dependent cytotoxic effect on these cells. From these results, HC at 10 ng/ml and AO at 5 µg/ml were chosen for mechanistic analysis. AO was able to decrease the oxidative molecules; however, both AO-and HC-induced differential and varied gene expression modulation of these enzymes. AO partially reverted the protein and gene expression of apoptotic markers that were higher in HC-exposed cells. AO also increases the BDNF levels, which are lower HC-exposed cultures. The results indicate that AO could be a beneficial supplement in situations where cortisol levels are elevated, including chronic psycho-environmental stress. Practical applications Psychological chronic stress that induces high cortisol exposure has been linked to premature aging and decreased healthy life expectancy. Neurobiological models involving cortisol have suggested a neurotoxic effect of this molecule, increasing the risk of psychiatric and other CNTDs. This effect can have a high impact mainly in How to cite this article: Motta JR, Jung IEDC, Azzolin VF, et al. Avocado oil (Persea americana) protects SH-SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules.

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“…In diabetic rats, the administration of avocado oil decreases the production of ROS and damage to brain lipids because of the increase in the GSH/GSSG ratio and the activity of complex III of the respiratory chain, which can reduce the half‐life of semiquinone intermediates and decrease the levels of ROS, as semiquinones are donors of electrons to oxygen, forming the superoxide anion (Ortiz‐Avila et al, ). Avocado oil supplementation to rats during gestation and lactation resulted in a higher concentration of MUFA and polyunsaturated fatty acids in the pups' brains and an improvement in cognitive function (de Melo et al, ).…”

Section: Avocado As a Nutraceuticalmentioning

confidence: 99%

Ginger and avocado as nutraceuticals for obesity and its comorbidities

Tramontin

Luciano

Marques

et al. 2020

Phytotherapy Research

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Obesity is a worldwide epidemic and is one of the factors involved in the etiology of type 2 diabetes mellitus. Obesity induces low-grade inflammation and oxidative stress. The treatment for obesity involves changes in diet, physical activity, and even medication and surgery. Currently, the use of nutraceutical compounds is associated with health benefits. Ginger and avocado are used for many people all around the world; however, its effect as a nutraceutical compound is less known by the general population. For this reason, we searched information of the literature to point its effects on distinct mechanisms of defense against the obesity its comorbidities. The present review aimed showing that these nutraceuticals may be useful in obesity treatment. Reports have shown that ginger and avocado induce antioxidant and antiinflammatory effects by improving enzymatic activity and modulating obesity-related impairments in the anti-inflammatory system in different tissues, without side effects.Furthermore, ginger and avocado were found to be effective in reversing the harmful effects of obesity on blood lipids. In conclusion, on the basis of the positive effects of ginger and avocado in in vitro, animal, and human studies, these nutraceuticals may be useful in obesity treatment. K E Y W O R D Sdiabetes treatment, inflammation, obesity, oxidative stress, phytotherapeutic approach, unhealthy diet

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Maternal Supplementation With Avocado (Persea americana Mill.) Pulp and Oil Alters Reflex Maturation, Physical Development, and Offspring Memory in Rats

Cited by 25 publications

References 94 publications

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

Avocado oil ( Persea americana ) protects SH‐SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules

Ginger and avocado as nutraceuticals for obesity and its comorbidities

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