Maternal stress, prenatal medical illnesses and obstetric complications: Risk factors for schizophrenia spectrum disorder, bipolar disorder and major depressive disorder

Pugliese, Valentina; Bruni, Antonella; Carbone, Elvira Anna; Calabrò, Giuseppina; Cerminara, Gregorio; Sampogna, Gaia; Luciano, Mario; Steardo, Luca; Fiorillo, Andrea; Segura-Garcia, Cristina; Fazio, Pasquale De

doi:10.1016/j.psychres.2018.11.023

Cited by 54 publications

(51 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The geometric effects of dendritic arborisation as a driver of cortical folding may therefore contribute to the sulcal asymmetries observed here. The evidence accumulating with regard to prenatal inflammatory exposure 62 , maternal stress, obstetric complications 63 , and expression of schizophrenia risk genes in fetal life as factors conferring vulnerability to schizophrenia would be of major relevance to how the intrauterine environment contributes to the variations in cortical folding that impact postnatal pathology. We hypothesize that auditory hallucinations in schizophrenia patients, and the accompanying patterns of brain function, result from alterations to the maturational trajectories in temporal and cingulate regions, and thus their structural covariance.…”

Section: Discussionmentioning

confidence: 99%

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

et al. 2020

View full text Add to dashboard Cite

All perception is a construction of the brain from sensory input. Our first perceptions begin during gestation, making fetal brain development fundamental to how we experience a diverse world. Hallucinations are percepts without origin in physical reality that occur in health and disease. Despite longstanding research on the brain structures supporting hallucinations and on perinatal contributions to the pathophysiology of schizophrenia, what links these two distinct lines of research remains unclear. Sulcal patterns derived from structural magnetic resonance (MR) images can provide a proxy in adulthood for early brain development. We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T MR imaging from the United Kingdom and Shanghai, China (n = 181 combined) and 63 healthy controls from Shanghai. Participants were stratified into those with (n = 79 UK; n = 22 Shanghai) and without (n = 43 UK; n = 37 Shanghai) hallucinations from the PANSS P3 scores for hallucinatory behaviour. We quantified the length, depth, and asymmetry indices of the paracingulate and superior temporal sulci (PCS, STS), which have previously been associated with hallucinations in schizophrenia, and constructed cortical folding covariance matrices organized by large-scale functional networks. In both ethnic groups, we demonstrated a significantly shorter left PCS in patients with hallucinations compared to those without, and to healthy controls. Reduced PCS length and STS depth corresponded to focal deviations in their geometry and to significantly increased covariance within and between areas of the salience and auditory networks. The discovery of neurodevelopmental alterations contributing to hallucinations establishes testable models for these enigmatic, sometimes highly distressing, perceptions and provides mechanistic insight into the pathological consequences of prenatal origins.

show abstract

Section: Discussionmentioning

confidence: 99%

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

et al. 2020

View full text Add to dashboard Cite

show abstract

“…However, more than one co-occurring OC was related to lower current IQ and greater decreases in IQ difference scores in all participant groups. Despite scientific reports that have stressed the role of OCs as a risk factor for the development of schizophrenia (Cannon et al, 2002b;Geddes and Lawrie, 1995;Nosarti et al, 2012;Pugliese et al, 2019), the precise nature of their relationship to cognitive functioning in psychiatric disorders is unknown. We report that severe OCs occurred in 28% of patients within the schizophrenia group, but we also observed similar numbers in both the bipolar patient group and healthy control group, which is comparable to what has been reported in other studies (Haukvik et al, 2009;Nicodemus et al, 2008;Ursini et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants

et al. 2019

View full text Add to dashboard Cite

Background Whether severe obstetric complications (OCs), which harm neural function in offspring, contribute to impaired cognition found in psychiatric disorders is currently unknown. Here, we sought to evaluate how a history of severe OCs is associated with cognitive functioning, indicated by Intelligence Quotient (IQ). Methods We evaluated the associations of a history of OCs and IQ in 622 healthy controls (HC) and 870 patients on the schizophrenia (SCZ) – bipolar disorder (BIP) spectrum from the ongoing Thematically Organized Psychosis study cohort, Oslo, Norway. Participants underwent assessments using the NART (premorbid IQ) and the WASI (current IQ). Information about OCs was obtained from the Medical Birth Registry of Norway. Multiple linear regression models were used for analysis. Results Severe OCs were equally common across groups. SCZ patients with OCs had lower performances on both premorbid and current IQ measures, compared to those without OCs. However, having experienced more than one co-occurring severe OC was associated with lower current IQ in all groups. Conclusions Severe OCs were associated with lower IQ in the SCZ group and in the BIP and HC groups, but only if they had experienced more than one severe OC. Low IQ might be a neurodevelopmental marker for SCZ; wherein, severe OCs influence cognitive abilities and increase the risk of developing SCZ. Considering OCs as a variable of neurodevelopmental risk for severe mental illness may promote the development of neuroprotective interventions, improve outcome in vulnerable newborns and advance our ability to make clinical prognoses.

show abstract

“…With neoteny a classic feature in the domestication syndrome, it is notable that small head circumference (less than 32 cm at birth) has been found to correlate with later diagnosis of BD by Pugliese et al (2019); inadequate maternal weight gain was inversely associated with BD (while positively associated with SZ). Considering another aspect of neoteny, evidence is mixed as to whether age at menarche is delayed (Bisaga et al, 2002) or not significantly different (Dunjic-Kostic et al, 2016) in women with BD compared to healthy controls (Williams et al, 2007; Tondo et al, 2017).…”

Section: Domestication Features In Bdmentioning

confidence: 99%

Abnormal features of human self-domestication in bipolar disorder

Benítez‐Burraco

Hansen

2020

Preprint

View full text Add to dashboard Cite

Bipolar disorder (BD) is a severe mental condition characterized by episodes of elevated mood and depression. Being a heritable condition, it features a complex genetic architecture, and it is not still clear how genes contribute to the onset and course of the disease. In this paper we adopted an evolutionary-genomic approach to this condition, focusing on changes occurring during human evolution as a source of our distinctive cognitive and behavioral phenotype. We show clinical evidence that the BD phenotype can be construed as an abnormal presentation of the human self-domestication phenotype. We further demonstrate that candidate genes for BD significantly overlap with candidates for mammal domestication, and that this common set of genes is enriched in functions that are important for the BD phenotype, especially neurotransmitter homeostasis. Finally, we show that candidates for domestication are differentially expressed in brain regions involved in BD pathology, particularly, the hippocampus and the prefrontal cortex. Overall, this link between domestication and BD should facilitate a better understanding of the BD etiopathology.

show abstract

Maternal stress, prenatal medical illnesses and obstetric complications: Risk factors for schizophrenia spectrum disorder, bipolar disorder and major depressive disorder

Cited by 54 publications

References 84 publications

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

Obstetric complications and intelligence in patients on the schizophrenia-bipolar spectrum and healthy participants

Abnormal features of human self-domestication in bipolar disorder

Contact Info

Product

Resources

About