Maternal speech shapes the cerebral frontotemporal network in neonates: A hemodynamic functional connectivity study

Uchida-Ota, Mariko; Arimitsu, Takeshi; Tsuzuki, Daisuke; Dan, Ippeita; Ikeda, Kazushige; Takahashi, Tsuyoshi; Minagawa, Yasuyo

doi:10.1016/j.dcn.2019.100701

Cited by 23 publications

(21 citation statements)

References 87 publications

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“…The present study focused on the oxy-Hb signal, which is generally used for the analysis of RSN in fNIRS measurements for both adults and infants because of its higher signal-to-noise ratio. 49 , 50 Furthermore, because most studies of infant RSN employed oxy-Hb or its equivalent signal with fMRI, 30 – 34 , 49 , 51 , 52 the oxy-Hb index made it possible to easily compare with previous results on infant RSN. For artifact rejection, we followed the procedure of Imai et al 51 If there was a signal change of more than 0.15 mM·mm in total Hb (sum of oxy-Hb and deoxy-Hb) between the mean of four successive samples (i.e., 400 ms) and that of the next 4 successive samples, the last time point in the first four samples was marked as an artifact.…”

Section: Methodsmentioning

confidence: 99%

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

et al. 2022

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Background Among preterm infants, higher morbidities of neurological disturbances and developmental delays are critical issues. Resting-state networks (RSNs) in the brain are suitable measures for assessing higher-level neurocognition. Since investigating task-related brain activity is difficult in neonates, assessment of RSNs provides invaluable insight into their neurocognitive development. Methods The participants, 32 term and 71 preterm neonates, were divided into three groups based on gestational age (GA) at birth. Cerebral hemodynamic activity of RSNs was measured using functional near-infrared spectroscopy in the temporal, frontal, and parietal regions. Results High-GA preterm infants (GA ≥ 30 weeks) had a significantly stronger RSN than low-GA preterm infants and term infants. Regression analyses of RSNs as a function of postnatal age (PNA) revealed a steeper regression line in the high-GA preterm and term infants than in the low-GA infants, particularly for inter-area brain connectivity between the frontal and left temporal areas. Conclusions Slower PNA-dependent development of the frontal–temporal network found only in the low-GA group suggests that significant brain growth optimal in the intrauterine environment takes place before 30 weeks of gestation. The present study suggests a likely reason for the high incidence of neurodevelopmental impairment in early preterm infants. Impact Resting-state fNIRS measurements in three neonate groups differing in gestational age (GA) showed stronger networks in the high-GA preterm infants than in the term and low-GA infants, which was partly explained by postnatal age (PNA). Regression analyses revealed a similar PNA-dependence in the development of the inter-area networks in the frontal and temporal lobes in the high-GA and term infants, and significantly slower development in the low-GA infants. These results suggest that optimal intrauterine brain growth takes place before 30 weeks of gestation. This explains one of the reasons for the high incidence of neurodevelopmental impairment in early preterm infants.

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Section: Methodsmentioning

confidence: 99%

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

et al. 2022

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“…Near-infrared spectroscopy (NIRS) is a handy, non-invasive tool, which has been used to analyse the tissue oxygen metabolism in the brains of newborn infants 8 – 11 . Near-infrared light penetrates the intact scalp, skull and cerebral tissue more efficiently than visible light, and is mainly absorbed by blood haemoglobin, the level of which depends on the binding of haemoglobin to oxygen 12 .…”

Section: Introductionmentioning

confidence: 99%

Foetal growth, birth transition, enteral nutrition and brain light scattering

Iwata

Kurata

et al. 2021

Sci Rep

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If the brain structure is assessed at neonatal intensive care units, covert clinical events related with subtle brain injury might be identified. The reduced scattering coefficient of near-infrared light (μS’) obtained using time-resolved near-infrared spectroscopy from the forehead of infants is associated with gestational age, body weight and Apgar scores, presumably reflecting subtle changes of the brain related to foetal growth and birth transition. One hundred twenty-eight preterm and term infants were studied to test whether μS’ obtained from the head at term-equivalent age is associated with foetal growth, birth transition and nutritional status after birth, which are key independent variables of developmental outcomes. As potential independent variables of μS’, birth weight, Apgar scores, age at full enteral feeding and post-conceptional age at the study were assessed to represent foetal growth, birth transition and nutritional status after birth. Subsequently, higher μS’ values were associated with higher Apgar scores (p = 0.003) and earlier establishment of enteral feeding (p < 0.001). The scattering property of near-infrared light within the neonatal brain might reflect changes associated with birth transition and nutritional status thereafter, which might be used as a non-invasive biomarker to identify covert independent variables of brain injury in preterm infants.

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“…In adults, the IF gyrus is considered part of the auditory dorsal stream and has been associated with language processing, especially speech production (that is, Broca’s area 50 – 52 ), speech comprehension 53 , 54 and speech monitoring 55 . Studies conducted in neonates and infants have associated activations in the IF region with discrimination of speech sounds 56 – 59 and a predictor of future language ability 60 . Therefore, our findings suggest that distinguishing between forward and backward vowels entails a change in neural effectiveness, resulting in latency changes, reminiscent of changes in the timecourse of the blood-oxygen-level dependent (BOLD) signal in fMRI observed in adults 32 , 61 , 62 .…”

Section: Discussionmentioning

confidence: 99%

“…After automatic detection (peak-to-peak >6 s.d.) and correction of spike ‘jumps’ using linear interpolation, optical intensity data were converted into optical density variations (ΔOD), followed by band-pass filtering between 0.01–0.2 Hz 25 , 59 . Filtered ΔOD timeseries for both wavelengths of interest were then transformed into relative concentration changes of oxyhaemoglobin (Δ[HbO]) and deoxyhemoglobin (Δ[Hb]), respectively.…”

Section: Methodsmentioning

confidence: 99%

Rapid learning of a phonemic discrimination in the first hours of life

Hou

Peng

et al. 2022

Nat Hum Behav

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Human neonates can discriminate phonemes, but the neural mechanism underlying this ability is poorly understood. Here we show that the neonatal brain can learn to discriminate natural vowels from backward vowels, a contrast unlikely to have been learnt in the womb. Using functional near-infrared spectroscopy, we examined the neuroplastic changes caused by 5 h of postnatal exposure to random sequences of natural and reversed (backward) vowels (T1), and again 2 h later (T2). Neonates in the experimental group were trained with the same stimuli as those used at T1 and T2. Compared with controls, infants in the experimental group showed shorter haemodynamic response latencies for forward vs backward vowels at T1, maximally over the inferior frontal region. At T2, neural activity differentially increased, maximally over superior temporal regions and the left inferior parietal region. Neonates thus exhibit ultra-fast tuning to natural phonemes in the first hours after birth.

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Maternal speech shapes the cerebral frontotemporal network in neonates: A hemodynamic functional connectivity study

Cited by 23 publications

References 87 publications

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

Differential age-dependent development of inter-area brain connectivity in term and preterm neonates

Foetal growth, birth transition, enteral nutrition and brain light scattering

Rapid learning of a phonemic discrimination in the first hours of life

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