Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats

Zhou, Jiantao; Gao, Shuang; Chen, Jinglong; Zhao, Ruqian; Yang, Xiaojing

doi:10.1186/s12944-016-0289-1

Cited by 15 publications

(18 citation statements)

References 39 publications

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“…Body weight of dams showed no significant difference between the butyrate group and the control group (28) . Maternal butyrate supplementation demonstrated a trend towards increasing litter weight, litter size (28) and the ratio of muscle weight:body weight (7·27 (SE 0·16) v. 6·79 (SE 0·19) g, P < 0·1) as well as enhanced muscle weight of the offspring (0·54 (SE 0·01) v. 0·48 (SE 0·02) g, P < 0·05) compared with the control group. The average weight of newborns (7·04 (SE 0·14) v. 7·18 (SE 0·12) g, P > 0·05) and the body weight of weaning rats (28) showed no significant differences between the two groups.…”

Section: Resultsmentioning

confidence: 78%

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Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring

et al. 2017

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The present study aimed to investigate the effects of maternal dietary butyrate supplementation on energy metabolism and mitochondrial biogenesis in offspring skeletal muscle and the possible mediating mechanisms. Virgin female rats were randomly assigned to either control or butyrate diets (1 % butyrate sodium) throughout gestation and lactation. At the end of lactation (21 d), the offspring were killed by exsanguination from the abdominal aorta under anaesthesia. The results showed that maternal butyrate supplementation throughout gestation and lactation did not affect offspring body weight. However, the protein expressions of G-protein-coupled receptors (GPR) 43 and 41 were significantly enhanced in offspring skeletal muscle of the maternal butyrate-supplemented group. The ATP content, most of mitochondrial DNA-encoded gene expressions, the cytochrome c oxidase subunit 1 and 4 protein contents and the mitochondrial DNA copy number were significantly higher in the butyrate group than in the control group. Meanwhile, the protein expressions of type 1 myosin heavy chain, mitochondrial transcription factor A, PPAR-coactivator-1α (PGC-1α) and uncoupling protein 3 were significantly increased in the gastrocnemius muscle of the treatment group compared with the control group. These results indicate for the first time that maternal butyrate supplementation during the gestation and lactation periods influenced energy metabolism and mitochondrial biogenesis through the GPR and PGC-1α pathways in offspring skeletal muscle at weaning. Key words: Maternal butyrate: Skeletal muscles: ATP: Mitochondrial biogenesis: RatsDietary fibre is deficient in the diets of modern people. The lack of dietary fibre is viewed as one of the main reason for the current increasing rates of metabolic diseases. Normally, dietary fibre is digested and absorbed in the gastrointestinal tract by complete or partial fermentation to SCFA such as butyric acid (1,2) . Considering the fibre effect on the diet of mothers during gestation and lactation, previous studies indicate that a high-fat, Western-style maternal diet, with additional dietary fibre, has a lower risk for developing CHD, hypertension, diabetes, obesity and other metabolic diseases in the offspring (3,4) . However, the underlying mechanism is still largely unclear.In addition to being the energy source for ruminants and monogastric animals (5,6) , most previous studies suggest that butyrate, a kind of SCFA, might mediate the effects of gut microbiota and nutrition on immunity, metabolism, as well as the pathogenesis of obesity, diabetes mellitus and inflammatory bowel disease (7)(8)(9)(10) . Previous studies have suggested that butyrate supplementation in high-fat diets could improve mitochondrial function by promoting a skeletal muscle type 1 fibre phenotype and physiology (10,11) . A few studies have demonstrated that maternal butyrate supplementation can improve offspring growth and antioxidant capacity (12,13) . However, whether maternal butyrate supplementation has an infl...

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Section: Resultsmentioning

confidence: 78%

“…1(a)). Our previous study has been reported that serum concentrations of total cholesterol and TGA in dams and weaned offspring did not change with butyrate supplementation (28) .…”

Section: Resultsmentioning

confidence: 79%

Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring

et al. 2017

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“…; Morrison & Preston ; Zhou et al . ). However, such information is lacking aquatic animals and yet to be explored.…”

Section: Conclusion and Perspectivementioning

confidence: 97%

“…Furthermore, there is currently limited information on the SCFAs receptors and the routes by which SCFAs positively or negatively influence metabolic functioning in aquatic animals. SCFAs elicit their beneficial effects by controlling the levels of fatty acid oxidation and fat storage in multiple tissues, as well as, regulating glucose homoeostasis in human and mice (den Besten et al 2013;Canfora et al 2015;Morrison & Preston 2016;Zhou et al 2016). However, such information is lacking aquatic animals and yet to be explored.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Progress and perspectives of short‐chain fatty acids in aquaculture

Tran

Wang

et al. 2018

Reviews in Aquaculture

117

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Gut microbiota is important and plays a crucial role in the host health and nutritional metabolism through multiple mechanisms. Short‐chain fatty acids (SCFAs), which are carboxylic acids with aliphatic tails < 6 carbons, are mainly produced by anaerobic microbiota through fermentation of carbohydrates in the intestine. Acetate, propionate and butyrate are the most abundant SCFAs metabolites, important in energy homoeostasis, metabolism and the maintenance of gut health. In this review, we describe and document what is known about the production, absorption, transport and receptors as well as the factors that affect SCFA production in aquatic animals. Some evidence on the roles that SCFAs as feed additives play in improving growth performance, digestibility, survival rate, immune responses, disease resistance and structure and function of the intestinal tract and abundance of commensal microbiota in aquatic animals is summarized. In addition, the immune regulatory mechanism of SCFAs is highlighted. Although the effects of SCFAs in aquatic animals have been explored, further research is needed to profoundly investigate the mechanisms that by which SCFAs induce their effects on host metabolism.

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“…Butyrate belongs to SCFAs and is an important gut microbial metabolite derived from fermentation of nondigestible polysaccharides. Butyrate has been demonstrated with critical role in affecting metabolic diseases development through a variety of ways including modulation of energy harvest, hepatic lipogenesis and gluconeogenesis, adipokine signaling in adipocytes, intestinal permeability and appetite regulation in brain [145,146]. Research showed that administration of sodium butyrate alleviated inflammation and fat accumulation in HFD-induced NAFLD mice by increasing the abundances of the beneficial bacteria Christensenellaceae, Blautia and Lactobacillus [147].…”

Section: Gut Microbiota-targeted Therapies With Other Approachesmentioning

confidence: 99%

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

Ma¹,

Zhou²,

Li³

2017

Preprint

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Gut microbiota play critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, and insulin resistance, which highlighted the potential of gut microbiota-targeted therapies on these diseases. There are various ways that can manipulate gut microbiota including probiotics, prebiotics, synbiotics, antibiotics and some active components from herbal medicines. In this review, we first described the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies in NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiotatargeted therapies in the future.

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Maternal sodium butyrate supplement elevates the lipolysis in adipose tissue and leads to lipid accumulation in offspring liver of weaning-age rats

Cited by 15 publications

References 39 publications

Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring

Supplementing the maternal diet of rats with butyrate enhances mitochondrial biogenesis in the skeletal muscles of weaned offspring

Progress and perspectives of short‐chain fatty acids in aquaculture

Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Therapy

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