Maternal smoking, pregnancy complications, and perinatal mortality

Meyer, Mary B.; Tonascia, James

doi:10.1016/0002-9378(77)90031-x

Cited by 231 publications

(80 citation statements)

References 11 publications

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“…However, as expected, we found that maternal smoking and history of PTB were the main risk factors for PTB in cases. This is in accordance with the present literature [3,5,16,17,20,25]. Conversely, bacterial vaginosis and LLETZ conisation were not associated with PTB in our study, although they represent established risk factors for PTB.…”

Section: Discussionsupporting

confidence: 93%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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Abstract.Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04-9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

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Section: Discussionsupporting

confidence: 93%

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

et al. 2013

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“…In 1957, Simpson (1957) first suggested an association between smoking and preterm delivery and identified a dose-response relationship between cigarette smoking and preterm delivery; he also reported that the incidence of low birth weight infants among smokers was nearly twice than among non-smokers. Other investigators have also reported similar conclusions (Meyer & Tonascia 1977, McDonald et al 1992, Meis et al 1995.…”

Section: Introductionsupporting

confidence: 71%

Cigarette smoke extract enhances oxytocin-induced rhythmic contractions of rat and human preterm myometrium

Nakamoto¹,

Yasuda²,

Yasuhara³

et al. 2006

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Although smoking during pregnancy is a major risk factor for preterm delivery, the underlying mechanism by which smoking stimulates uterine contractions is still poorly understood. In the present study, we tried to clarify the effects of smoking on myometrial contractility induced by oxytocin (OT) using cigarette smoke extract (CSE). Myometrial strips, which were taken from the rat on day 16 of pregnancy, and from human preterm and term delivery groups, were incubated overnight with several doses of CSE at 37 8C under non-hormonal conditions. The uterine contractile sensitivity and activity (force and frequency) upon exposure to OT were investigated. Furthermore, the expression levels of oxytocin receptor (OTR) mRNA in the myometrial strips were investigated by real-time PCR. Contractile sensitivity to OT in the rat CSE (10 K7 pieces/ml) group was found to be significantly higher than in the control group (P!0.05). Contractile activity did not differ between the CSE and control groups. The expression levels of rat OTR mRNA in the CSE (10 K7 pieces/ml) group were significantly higher than in the control group (P!0.01). Similarly, in preterm myometrial strips, the expression levels of human OTR mRNA in the CSE (10 K7 pieces/ml) group were significantly higher than in the control group (P!0.05). These findings suggest that CSE directly increases the contractile sensitivity of preterm myometrium in response to OT by upregulating the expression of OTR mRNA and thereby increases the risk of preterm delivery in women, who smoke during pregnancy.

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“…Mothers who smoke around the time of conception, nearly double their risk of smallfor-gestational age (SGA) birth (30). In an American study, the risk of having a low-birth-weight baby under 2,500 grams was 49 per thousand for nonsmokers, 76 per thousand for smokers of less than twenty cigarettes per day and 114 per thousand for smokers of twenty cigarettes or more per day (31). Women older than 30 years who smoke, enter pregnancy underweight and have a previous lowbirthweight delivery are at greatest risk of delivering a SGA baby (30,32).…”

Section: Birth Weightmentioning

confidence: 99%

Smoking among pregnant women - epidemiology and health consequences

Haug¹

2009

Nor J Epidemiol

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Smoking during pregnancy is an important, preventable risk factor for late fetal death and even SIDS. There is a strong dose-response relationship between cigarette smoking and spontaneous abortion, reduction in birth weight, abruptio placentae, placenta previa and bleeding during pregnancy. Ten years ago, the prevalence of smoking among Norwegian pregnant women was between 35 and 40%. During the last 8 years there has been a dramatic change and in 1995 the prevalence seems to be around 20%.

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Maternal smoking, pregnancy complications, and perinatal mortality

Cited by 231 publications

References 11 publications

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Cigarette smoke extract enhances oxytocin-induced rhythmic contractions of rat and human preterm myometrium

Smoking among pregnant women - epidemiology and health consequences

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