Maternal smoking in pregnancy is associated with cholesterol development in the offspring: A 27-years follow-up study

Jaddoe, Vincent W.V.; Ridder, Maria A. J. de; Elzen, Annette P. M. van den; Hofman, Albert; Uiterwaal, Cuno S.P.M.; Witteman, Jacqueline C. M.

doi:10.1016/j.atherosclerosis.2007.01.032

Cited by 62 publications

(54 citation statements)

References 24 publications

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“…Limitations include the lack of data on intrauterine exposure to maternal and paternal tobacco smoke, an exposure that numerous studies have previously demonstrated to possess clear long-term adverse effects in relation to offspring general and cardiovascular health, specifically related to BMI, 28 total cholesterol, 29 and hypertension. 30 Our results indicated that children 3 to 9 years of age had a greater adverse effect of unhygienic smoking than those 12 to 18 years of age, indicating a possible period of increased vulnerability, although this finding was statistically insignificant.…”

Section: 31516mentioning

confidence: 99%

Exposure to Parental Smoking in Childhood Is Associated With Increased Risk of Carotid Atherosclerotic Plaque in Adulthood

et al. 2015

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Background-The association between passive smoking exposure in childhood and adverse cardiovascular health in adulthood is not well understood. Using a 26-year follow-up study, we examined whether childhood exposure to passive smoking was associated with carotid atherosclerotic plaque in young adults. Methods and Results-Participants were from the Cardiovascular Risk in Young Finns Study (n=2448). Information on childhood exposure to parental smoking was collected in 1980 and 1983. Carotid ultrasound data were collected in adulthood in 2001 or 2007. Childhood serum cotinine levels from 1980 were measured from frozen samples in 2014 (n=1578). The proportion of children with nondetectable cotinine levels was highest among households in which neither parent smoked (84%), was decreased in households in which 1 parent smoked (62%), and was lowest among households in which both parents smoked (43%). Regardless of adjustment for potential confounding and mediating variables, the relative risk of developing carotid plaque in adulthood increased among those children with 1 or both parents who smoked (relative risk, 1.7; 95% confidence interval, 1.0-2.8; P=0.04). Although children whose parents exercised good "smoking hygiene" (smoking parents whose children had nondetectable cotinine levels) had increased risk of carotid plaque compared with children with nonsmoking parents (relative risk, 1.6; 95% confidence interval, 0.6-4.0; P=0.34), children of smoking parents with poor smoking hygiene (smoking parents whose children had detectable serum cotinine levels) had substantially increased risk of plaque as adults (relative risk, 4.0; 95% confidence interval, 1.7-9.8; P=0.002). Conclusions-Children

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Section: 31516mentioning

confidence: 99%

Exposure to Parental Smoking in Childhood Is Associated With Increased Risk of Carotid Atherosclerotic Plaque in Adulthood

et al. 2015

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“…18,19 Recently, it was indicated that maternal smoking in pregnancy is associ-ated with an increase in total cholesterol levels and trends toward adverse lipoprotein profiles in the young adult offspring. 20 However, there are no data on the relations of exposure to tobacco smoke and apolipoprotein (Apo) levels in children or adolescents.…”

mentioning

confidence: 99%

Arterial Intima-Media Thickness, Endothelial Function, and Apolipoproteins in Adolescents Frequently Exposed to Tobacco Smoke

Kallio

Jokinen

Saarinen

et al. 2010

Circ: Cardiovascular Quality and Outcomes

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Background-Exposure to tobacco smoke is associated with markers of preclinical atherosclerosis in adults, but its effect on arterial structure in adolescents is unknown. Methods and Results-Healthy 13-year-old adolescents from the atherosclerosis prevention trial STRIP were studied.Maximum carotid and aortic intima-media thickness and brachial artery flow-mediated dilation were measured in 494 adolescents using high-resolution ultrasound. Serum lipid, lipoprotein, and apolipoprotein (Apo) A-I and B concentrations were determined using standard methods. Exposure to tobacco smoke was measured annually between ages 8 and 13 years using serum cotinine concentrations, analyzed with gas chromatography. To define longitudinal exposure, cotinine values of children having serum cotinine measured 2 to 6 times during follow-up were averaged and divided into tertiles (exposure groups): low (nϭ160), intermediate (nϭ171), and high (nϭ163 1 Passive smoking has been associated with attenuated endothelium-dependent dilation in young healthy adults. 2,3 We have previously shown in 11-year-old healthy children that tobacco smoke exposure is associated with endothelial dysfunction measured by flowmediated dilation (FMD) of the brachial artery. 4 In addition, both past and current passive smoking has been related with increased carotid intima-media thickness (cIMT) in adults. [5][6][7] Moreover, tobacco smoke exposure in pregnancy has recently been associated with increased aortic intima-media thickness (aIMT) in neonates 8 and increased cIMT in young adulthood. 9 Conventional cardiovascular risk factors have been related to early structural vascular wall changes in childhood, 10 -12 and exposure to cardiovascular risk factors in adolescence predicts increased adult cIMT. 13 However, none of the previous studies has examined the impact of exposure to tobacco smoke on IMT in healthy children or adolescents.Exposure to tobacco smoke may lead to alterations in serum lipid profile, especially to decrease in HDL cholesterol, in children 14,15 and adolescents. 16,17 In adults, heavy workplace exposure to tobacco smoke has been demonstrated to have an adverse influence on serum lipids. 18,19 Recently, it was indicated that maternal smoking in pregnancy is associ- 21 Exposure to tobacco smoke as indicated by objective measurement, serum cotinine concentration, has been frequently determined in school-aged children. The aim of the present study was to examine the effects of frequent exposure to tobacco smoke on vascular wall structure, endothelial function, and serum lipid profile in healthy 13-year-old adolescents. WHAT IS KNOWN• Exposure to environmental tobacco smoke is related to increased carotid intima-media thickness in adults, but this association has not been studied in children.• Exposure to environmental tobacco smoke may lead to alterations in serum lipid profile, but there are no data on the relations of tobacco smoke exposure and apolipoprotein levels in children. WHAT THE STUDY ADDS• This study shows that frequent exposure ...

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“…Maternal behaviours such as smoking, high alcohol consumption, and ingesting illicit drugs have all been recognised as contributors to the risk of IUGR and premature birth [123][124][125][126][127]. Cigarette smoking has been reported to increase the risk of premature rupture of the membranes, pregnancy bleeding and pre-term labour.…”

Section: Maternal Lifestylementioning

confidence: 99%

“…In a cohort of 3000 African American women, alcohol and cocaine use was found to be associated with extreme preterm birth [125]. Of particular concern, a study by O'Leary et al [127], found that moderate ingestion of alcohol consumption (only during the first trimester of pregnancy) was associated with pre-term birth In Australia, the high rate of preterm birth in the Indigenous community is thought to be attributed to high rates of tobacco, alcohol and drug use in pregnant women [130].…”

Section: Maternal Lifestylementioning

confidence: 99%

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

Ryan¹,

Black²

2015

J Neonatal Biol

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Preterm birth (defined as birth prior to 37 completed weeks of gestation), occurs in approximately 10% of all births and is one of the leading causes of neonatal morbidity and mortality worldwide. Preterm infants are born at a time when kidney development is still ongoing, and consequently can lead to renal impairment (in both the short-term and long-term), as well as severe glomerular abnormalities in some preterm infants. Since the glomerular abnormalities are not present in all preterm kidneys, this suggests that it is not preterm birth per se that leads to the glomerular abnormalities but may relate to factors associated with the etiology of the premature delivery, or factors in neonatal care. In this review, we provide an overview of what is currently known of how prenatal and postnatal factors can potentially impact on the immature kidneys of infants born preterm.

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Maternal smoking in pregnancy is associated with cholesterol development in the offspring: A 27-years follow-up study

Cited by 62 publications

References 24 publications

Exposure to Parental Smoking in Childhood Is Associated With Increased Risk of Carotid Atherosclerotic Plaque in Adulthood

Exposure to Parental Smoking in Childhood Is Associated With Increased Risk of Carotid Atherosclerotic Plaque in Adulthood

Arterial Intima-Media Thickness, Endothelial Function, and Apolipoproteins in Adolescents Frequently Exposed to Tobacco Smoke

Preterm Birth and/or Factors that Lead to Preterm Delivery: Effects on the Neonatal Kidney

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