Maternal Serum Uric Acid as a Marker of Predicting Low Birth Weight at Term Pregnancy: A Study Based in CMH Lahore

Abstract

Objective: To determine the association of hyperuricemia with adverse pregnancy outcomes in terms of low birth weight at term pregnancy registered at CMH Lahore.
 Study Design: Prospective cohort study.
 Place and Duration of Study: Department of Obstetrics and Gynecology of CMH, Lahore Pakistan, from Aug 2018 to Feb 2019.
 Methodology: A total of 60 pregnant women with a singleton pregnancy were included in the study. Patients with serum uric acid levels greater or equal to 360 umol/L were included in Group-A or the at-risk Group, and Patients with serum uric acid levels less than 360 umol/L were included in Group-B or the control Group. All women were followed till the delivery. Data regarding adverse pregnancy outcomes (low birth weight) was noted.
 Results: Mean Serum uric acid levels of 380.33±12.92 umol/L in the Exposed Group and mean Serum uric acid levels of 265.66±29.44 umol/L in the Control Group were noted. Low birth weight was seen 12 (40%) in Exposed Group as compared to 7(23.3%) in Unexposed Group (p=0.165) (RR=1.71).
 Conclusion: Low birth weight at term was not associated with hyperuricemic pregnancy more than normouricemic pregnancy in our study, probably due to the small sample size.

Mode and Success Rate of Delivery of Live Births Following Emergency Cervical Cerclage

“…Cervical incompetence is a disorder in which the cervix is either physically or functionally weak, leading to painless cervical effacement and dilatation that results in the loss of the fetus before viability during the second trimester. (1,2). Preterm birth is one of the leading causes of perinatal mortality and morbidity.…”