Maternal serum nitric oxide levels associated with biochemical and clinical parameters in hypertension in pregnancy

Bartha, José Luis; Comino-Delgado, Rafael; Bedoya, Francisco J.; Barahona, Manel; Lubián, Daniel; García-Benasach, F.

doi:10.1016/s0301-2115(98)00234-6

Cited by 19 publications

(8 citation statements)

References 25 publications

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“…The easiest way to stimulate a pre‐eclampsia‐like syndrome in rats and mice is to block production of NO by administering a NOS‐inhibiting agent 14 . This produces virtually all the symptoms of pre‐eclampsia in the animal model, suggesting a direct relationship between NO production and the vascular changes in a normal pregnancy, but research to evaluate NO production in humans has been contradictory 15–22 . Here we demonstrated that NO levels were reduced in pre‐eclamptic women when compared to normal controls.…”

Section: Discussionmentioning

confidence: 74%

Plasma nitric oxide, endothelin‐1, arginase and superoxide dismutase in pre‐eclamptic women

Bernardi

Constantino

Machado

et al. 2008

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 74%

Plasma nitric oxide, endothelin‐1, arginase and superoxide dismutase in pre‐eclamptic women

Bernardi

Constantino

Machado

et al. 2008

J of Obstet and Gynaecol

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“…The decreased NO ∙ levels observed in women with preeclampsia in our study agrees with the findings of some similar studies [ 22 , 23 ]. Conversely, other studies observed significantly increased NO ∙ levels in preeclampsia compared to normal pregnancy [ 9 , 24 , 25 ], while others observed no change in NO ∙ levels compared to normal pregnancy [ 26 , 27 ]. Particularly, a study conducted in Ghana by Adu-Bonsaffoh et al [ 9 ] observed an elevated NO ∙ level in preeclampsia compared to normotensive pregnancy.…”

Section: Discussionmentioning

confidence: 94%

Altered Bioavailability of Nitric Oxide and L-Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

Tashie

Fondjo

Owiredu

et al. 2020

BioMed Research International

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Background. Preeclampsia is a major cause of maternal and neonatal morbidity and mortality in sub-Saharan Africa. Evidence indicates that endothelial dysfunction is central to the pathogenesis of preeclampsia. This study assessed the level of the components of the arginine-nitric oxide pathway to evaluate endothelial dysfunction in normotensive pregnancies and pregnancies complicated with preeclampsia. Methods. This case-control study was conducted among pregnant women who visited Comboni Hospital from January 2017 to May 2018. A total of 180 pregnant women comprising 88 preeclamptic women (PE) and 92 healthy normotensive pregnant women (NP) were recruited. Sociodemographic, clinical, and obstetric data were obtained using validated questionnaires. Blood pressure and anthropometrics were measured, and blood samples were collected for the estimation of nitric oxide (NO∙), L-arginine, asymmetric dimethylarginine (ADMA), and 3-nitrotyrosine using an enzyme-linked immunosorbent assay technique. Results. The mean NO∙ ( p = 0.010 ) and L-arginine/ADMA ratio ( p < 0.0001 ) was significantly lower in PE compared to NP while mean L-arginine ( p = 0.034 ), ADMA ( p < 0.0001 ), and 3-nitrotyrosine ( p < 0.0001 ) were significantly higher in PE than NP. ADMA showed a significant positive association with systolic blood pressure ( β = 0.454 , p = 0.036 ) in severe PE. Women with PE had significant intrauterine growth restriction ( p < 0.0001 ) and low birth weight infants ( p < 0.0001 ) when compared to NP. Conclusion. Preeclampsia is associated with reduced NO∙ bioavailability, L-arginine/ADMA ratio, and elevated levels of ADMA and 3-nitrotyrosine. Measurements of the levels of these parameters can help in the early prediction of endothelial dysfunction in preeclampsia. Exogenous therapeutic supplementation with L-arginine during pregnancy to increase the L-arginine/ADMA ratio should be considered to improve endothelial function in preeclampsia and pregnant women at risk of developing preeclampsia.

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“…Plasma NO x is markedly elevated in sepsis and inflammation, 28 but large-scale studies of this parameter in disorders in which the NO pathway appears downregulated are more limited. Some studies indicate a reduction in circulating or urinary nitrogen oxides in essential hypertension 29 or the hypertensive disorders of pregnancy, 30 but studies have been relatively small and the findings inconsistent, 31 possibly because of the difficulty in applying the Griess assay for NO x to large numbers of subjects. However, the technique developed in the present study allowed simultaneous analysis of large numbers of plasma samples in 96-well microtiter plates.…”

Section: Cardiovascular Risk Factors No Pathway and In Vivo Measurementioning

confidence: 99%

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease

Jeerooburkhan

Jones²,

Bujac³

et al. 2001

Hypertension

106

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Abstract-Endothelial dysfunction, caused in part by reduced NO bioavailability, is a feature of hypercholesterolemia, hypertension, smoking, and atherosclerosis. We examined whether cholesterol, blood pressure, smoking status, and polymorphisms in the endothelial NO synthase gene (NOS 3) influence NO production (as assessed by the plasma levels of nitrogen oxides, NO x ) in middle-aged men. We also determined whether plasma NO x or NOS 3 genotype predicted the risk of ischemic heart disease (IHD). We studied 3052 men who were initially free of IHD and recruited from 9 UK primary care practices. Blood pressure, age, body mass index, serum cholesterol, and smoking status were assessed at baseline and annually over 8

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Maternal serum nitric oxide levels associated with biochemical and clinical parameters in hypertension in pregnancy

Cited by 19 publications

References 25 publications

Plasma nitric oxide, endothelin‐1, arginase and superoxide dismutase in pre‐eclamptic women

Plasma nitric oxide, endothelin‐1, arginase and superoxide dismutase in pre‐eclamptic women

Altered Bioavailability of Nitric Oxide and L-Arginine Is a Key Determinant of Endothelial Dysfunction in Preeclampsia

Genetic and Environmental Determinants of Plasma Nitrogen Oxides and Risk of Ischemic Heart Disease

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