Maternal Serum Interleukin-6, C-Reactive Protein, and Matrix Metalloproteinase-9 Concentrations as Risk Factors for Preterm Birth &lt;32 Weeks and Adverse Neonatal Outcomes

Sorokin, Yoram; Romero, Roberto; Mele, Lisa; Wapner, Ronald J.; Iams, Jay D.; Dudley, Donald J.; Spong, Catherine Y.; Peaceman, Alan M.; Leveno, Kenneth J.; Harper, Margaret; Caritis, Steve N.; Miodovnik, Menachem; Mercer, Brian M.; Thorp, John M.; OʼSullivan, Mary J.; Ramin, Susan M.; Carpenter, Marshall W.; Rouse, Dwight J.; Sibai, Baha M.

doi:10.1055/s-0030-1249366

Cited by 147 publications

(110 citation statements)

References 42 publications

(66 reference statements)

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“…Sorokin et al [31] evaluated the maternal serum concentration of interleukin-6 (IL-6), C-Reactive Protein (CRP), and matrix metalloproteinase-9 (MMP-9) as potential predictive factors of preterm delivery. Among the patients, who have any symptoms of threatened preterm delivery and intact membranes, only maternal serum concentrations of IL-6 and CRP, but not MMP-9 were associated with higher risk of preterm delivery <32 weeks.…”

Section: Discussionmentioning

confidence: 99%

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Kuć

Lemancewicz²,

Laudański³

et al. 2010

Folia Histochem Cytobiol.

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Preterm labour and prematurity are still a main cause of perinatal morbidity nowadays. The aim of our study was to assess the role of MMP-8 as a predictive marker of preterm delivery. Four groups of patients were involved to the study: I -pregnant women at 24-34 weeks of gestation with any symptoms of threatened preterm labour; II -threatened preterm labour patients between 24-34 weeks of gestation; III -preterm vaginal delivery patients; IV -healthy term vaginal delivery patients. Serum concentration of total MMP-8 was measured using two enzyme-linked immunosorbent assays. There were no significant differences in the median concentrations of total MMP-8 between physiological pregnancy and threatened preterm labour patients with existing uterine contractility. No significant differences of total MMP-8 were either found between healthy term and preterm labouring patients. The studies on a larger population are needed to reject the hypothesis that preterm labour is connected with increased MMP-8 plasma concentrations of women in preterm labour and threatened preterm delivery.

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Section: Discussionmentioning

confidence: 99%

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Kuć

Lemancewicz²,

Laudański³

et al. 2010

Folia Histochem Cytobiol.

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“…To test this, we combined murine models of systemic maternal inflammation and postnatal viral challenge. We chose low-dose lipopolysaccharide (LPS) treatment of dams based on its capacity to induce secondary postnatal inflammation (3,4) and its relevance to subclinical maternal inflammation and prematurity in humans (8,9). Neonatal and weanling offspring of LPStreated mothers or controls were secondarily infected with the murine respiratory pathogen, Sendai virus (SeV), an analog of human respiratory syncytial virus (RSV) infection, to assess the influence of maternal inflammation on postnatal immune responses.…”

mentioning

confidence: 99%

Maternal inflammation modulates infant immune response patterns to viral lung challenge in a murine model

et al. 2014

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Background: Chorioamnionitis, an inflammatory gestational disorder, commonly precedes preterm delivery. Preterm infants may be at particular risk for inflammation-related morbidity related to infection, although the pathogenic mechanisms are unclear. We hypothesized that maternal inflammation modulates immune programming to drive postnatal inflammatory processes. Methods: We used a novel combined murine model to treat late gestation dams with low-dose lipopolysaccharide (LPS) and to secondarily challenge exposed neonates or weanlings with Sendai virus (SeV) lung infection. Multiple organs were analyzed to characterize age-specific postnatal immune and inflammatory responses. results: Maternal LPS treatment enhanced innate immune populations in the lungs, livers, and/or spleens of exposed neonates or weanlings. Secondary lung SeV infection variably affected neutrophil, macrophage, and dendritic cell proportions in multiple organs of exposed pups. Neonatal lung infection induced brain interleukin (IL)-4 expression, although this response was muted in LPS-exposed pups. Adaptive immune cells, including lung, lymph node, and thymic lymphocytes and lung CD4 cells expressing FoxP3, interferon (IFN)-γ, or IL-17, were variably prominent in LPS-exposed pups. conclusion: Maternal inflammation modifies postnatal immunity and augments systemic inflammatory responses to viral lung infection in an age-specific manner. We speculate that inflammatory modulation of the developing immune system contributes to chronic morbidity and mortality in preterm infants. c horioamnionitis, an antenatal inflammatory disorder, is detected in the majority of placentas following extremely preterm delivery (1). The resultant fetal inflammation has been associated with postnatal development of chronic inflammatory disorders, including retinopathy of prematurity, periventricular leukomalacia, bronchopulmonary dysplasia, and necrotizing enterocolitis (2-4). However, the pathogenic role of chorioamnionitis in neonatal morbidity, particularly regarding

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“…These activated leukocytes release stress mediators that are basis for pluri-visceral damages, alteration of sub-decidual angiogenesis, reduction in intrauterine blood flow and mother-fetus transfer of stress substances, resulting in myometrial irritability and fetal inflammatory climate [25]. These effects are accountable for in reportedly high frequencies of pregnancy loss [26], shortening of gestational age, prematurity, restriction of birth weight [27]- [33] and neonatal intravascular hemorrhage [34] in increase of maternal blood pressure, which is likely to lead not only to preeclampsia-eclampsia (PE) but also to intrauterine growth restriction (IUGR) and premature labor [41].…”

Section: A M Mbangama Et Al Open Journal Of Obstetrics and Gynecologymentioning

confidence: 99%

Rationale of a Cohort Study on Risk of Obstetrical Outcomes Associated with Iron Supplementation during Pregnancy

Mbangama¹,

Tandu-Umba²,

Mbungu³

2018

OJOG

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Background: Anemia is one of the most widely prevalent disorders, affecting the lives of almost half a billion women of reproductive age, contributing to over 100,000 maternal and almost 600,000 perinatal deaths (mostly through pre-term delivery, low birth weight) each year. Increased risk of infant mortality and reduced cognitive development and reduced energy levels which affect productivity in adults are cited. During pregnancy increased requirements, inadequate intake of iron and other micronutrients and parasitic (malaria, hookworm) as wells as bacterial (mostly urinary tract) infections are the main causes. In order to reduce such maternal and neonatal burden, it has been worldwide admitted to adopt cost-effective preventive interventions during pregnancy, including iron-folic acid supplementation, de-hookworming medication and anti-malarial prevention or treatment. Intestinal absorption of iron is limited by a lot of factors including bioavailability, iron status of the woman, substances accompanying or contained in diet, chelating agents such as diet fibers or calcium salts. Any supplementation put additional constraint in terms of absorption. Unabsorbed iron is known to have pro-oxidant properties likely to induce production of free radicals. These in turn might induce oxidative stress accountable for in generation of many obstetrical outcomes. This potential link between oxidative stress resulting from free radicals hyperproduction induced by non absorbed iron and harmful maternal/perinatal conditions is rarely questioned by searchers. Objectives: To determine overall (food and supplemented) iron consumption, iron and oxidative status in a cohort of pregnant women and to seek associations between findings and adverse obstetrical outcomes. Methods: At the University Clinics of Kinshasa, we designed a protocol for a prospective cohort study dealing with clinical and biochemical parameters of oxidative stress among pregnant women iron supplemented. Women with a single pregnancy not exceeding 19 weeks without obvious pathology, regardless of age and parity, were eligible for inclusion in the study. Conclusion: This study is expected to assess consequences of oral iron supplementation during pregnancy in terms of obstetrical outcomes associated with oxidative stress linked to unabsorbed iron.

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Maternal Serum Interleukin-6, C-Reactive Protein, and Matrix Metalloproteinase-9 Concentrations as Risk Factors for Preterm Birth <32 Weeks and Adverse Neonatal Outcomes

Cited by 147 publications

References 42 publications

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Total matrix metalloproteinase-8 serum levels in patients labouring preterm and patients with threatened preterm delivery.

Maternal inflammation modulates infant immune response patterns to viral lung challenge in a murine model

Rationale of a Cohort Study on Risk of Obstetrical Outcomes Associated with Iron Supplementation during Pregnancy

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