Maternal serum glycosylated hemoglobin and fasting plasma glucose predicts gestational diabetes at the first trimester in Turkish women with a low-risk pregnancy and its relationship with fetal birth weight; a retrospective cohort study

Kansu-Celik, Hatice; Özgü-Erdinç, A. Seval; Kısa, Burcu; Eldem, Sinem; Hancerliogullari, Necati; Engin-Üstün, Yaprak

doi:10.1080/14767058.2019.1651837

Cited by 14 publications

(18 citation statements)

References 33 publications

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“…Sweeting et al 36 also found higher first‐trimester glucose levels in women with GDM compared with controls, but did not include glucose in their final model. Reported discrimination for first‐trimester glucose only was similar to our findings, with c ‐statistics ranging from 0.58 to 0.73 in literature compared with 0.68 (95% CI 0.65–0.72) in our study 37–43 …”

Section: Discussionsupporting

confidence: 91%

“…Reported discrimination for first-trimester glucose only was similar to our findings, with c-statistics ranging from 0.58 to 0.73 in literature compared with 0.68 (95% CI 0.65-0.72) in our study. [37][38][39][40][41][42][43] Risk factors are embedded in most international guidelines for GDM and these could all potentially benefit by replacing their risk-factor-based approach with a more efficient prognostic model. 13 In countries were glucose is not routinely measured in the first trimester of pregnancy, implementation of a prognostic model for GDM can still be considered, as most prognostic models without the addition of glucose seem to outperform the reference method as well.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic models versus single risk factor approach in first‐trimester selective screening for gestational diabetes mellitus: a prospective population‐based multicentre cohort study

Hoorn

Koster

Naaktgeboren

et al. 2020

BJOG

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Objectives To evaluate whether (1) first-trimester prognostic models for gestational diabetes mellitus (GDM) outperform the currently used single risk factor approach, and (2) a first-trimester random venous glucose measurement improves model performance. Design Prospective population-based multicentre cohort. Setting Thirty-one independent midwifery practices and six hospitals in the Netherlands. Population Women recruited before 14 weeks of gestation without pre-existing diabetes. Methods The single risk factor approach (presence of at least one risk factor: BMI ≥30 kg/m 2 , previous macrosomia, history of GDM, positive first-degree family history of diabetes, non-western ethnicity) was compared with the four best performing models in our previously published external validation study (

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Prognostic models versus single risk factor approach in first‐trimester selective screening for gestational diabetes mellitus: a prospective population‐based multicentre cohort study

Hoorn

Koster

Naaktgeboren

et al. 2020

BJOG

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“…Individually, FPG and triglycerides have been tested to predict the risk of GDM. FPG was studied in retrospective 16,17 and prospective 18,19 studies using different GDM algorithms. Overall, FPG levels above 81 to 90 mg/dL have been described for pregnancies complicated with GDM.…”

Section: Discussionmentioning

confidence: 86%

Early triglyceride and glucose index as a risk marker for gestational diabetes mellitus

Sánchez‐García

Rodríguez-Gutiérrez

Saldívar-Rodríguez

et al. 2020

Intl J Gynecology & Obste

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Objective To assess the risk of gestational diabetes mellitus (GDM) according to the triglyceride and glucose (TyG) index values during the first trimester of pregnancy in Latin American women. Methods Pregnant women were enrolled at their first prenatal visit at the Obstetric Division in the University Hospital “Dr. José E. González”. Triglycerides and fasting plasma glucose (FPG) were collected to determine the TyG index. GDM diagnosis was performed by a single‐step 2‐hour 75‐g oral glucose tolerance test. Generalized linear models were used to determine risk ratios; pregnancy outcomes at delivery were collected from the hospital medical records. Results A total of 164 pregnant women were included. GDM was present in 29 (17.7%) women. No significant differences in age, first‐trimester body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters), family history of diabetes, and TyG index were observed between GDM cases and the reference group without GDM. The adjusted analysis showed no association between TyG and GDM (risk ratio [RR] 1.03, 95% confidence interval [CI] 0.57–1.88]). Higher TyG index values between women with and without a diagnosis of GDM in the second trimester were observed. No significant differences were identified in pregnancy outcomes, although a trend was observed for hyperbilirubinemia in women with first‐trimester TyG index values greater than 8.7. Conclusions Our findings do not support the use of the TyG index for GDM prediction in Latin American women.

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“…It can reliably reflect the blood glucose level for the preceding 8-12 weeks as the lifespan of erythrocytes is within that range. 11,23 Measuring the HbA1c level within the first trimester of pregnancy can provide the estimation of maternal glycemic condition before pregnancy or in early pregnancy as the insulin sensitivity in that period should be higher. The HbA1c level is expected to drop by at least 0.5% as a result of higher insulin sensitivity and shorter lifespan of erythrocytes during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

“…HbA1c level is linked to the glucose level in the blood and also the erythrocyte lifetime. 11 HbA1C itself has been known as a predictor and a diagnostic test for type 2 diabetes. However, this test has not been widely studied in GDM and no cutoff point has been defined for HbA1C in GDM.…”

Section: Introductionmentioning

confidence: 99%

First Trimester Glycated Hemoglobin (HBA1C) Level as a Novel Predictor of Gestational Diabetes Mellitus: a Systematic Review and Meta-Analysis

Kalaij

Dyson

Sugiyanto

2021

J Asian Med Stud Assoc

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Introduction: Gestational diabetes mellitus (GDM) is a severe yet neglected threat to maternal and child health, due to its association with multiple adverse pregnancy outcomes. glycated hemoglobin (HbA1c) level is one of the most promising predictor of GDM in early pregnancy based on several cohort studies done recently. Purpose of study: This systematic review and meta-analysis aims to evaluate the potency of HbA1c level in first trimester as a novel predictor of GDM. Methods: This review selects cohort studies found by database searching systematically using previously determined inclusion, such as pregnant woman as the subject, assess Hb1Ac level in the first trimester, and assess odds ratio towards (GDM), and exclusion criteria such as assess outcome at postpartum, not assess GDM outcomes, and studies written in languages other than English or Bahasa Indonesia. This review was arranged based on PRISMA guideline. Results and Discussion: This review included seven cohort studies with the pooled OR of 4.36 [95%CI: 3.66-5.20]. Quantitative analysis shows that HbA1c level in the first trimester is a significant risk factor of GDM development (p<0.00001). However, heterogeneity analyses revealed substantial heterogeneity are detected in the pooled studies. Therefore, to understand the significance of HbA1c level and the development of GDM, further studies are needed. Conclusion: This study has proven the potency of first trimester HbA1c level as a novel predictor of gestational diabetes mellitus. Thus, it is necessary to integrate the use of HbA1c level screening as part of antenatal care in the first trimester of pregnancy.

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Maternal serum glycosylated hemoglobin and fasting plasma glucose predicts gestational diabetes at the first trimester in Turkish women with a low-risk pregnancy and its relationship with fetal birth weight; a retrospective cohort study

Cited by 14 publications

References 33 publications

Prognostic models versus single risk factor approach in first‐trimester selective screening for gestational diabetes mellitus: a prospective population‐based multicentre cohort study

Prognostic models versus single risk factor approach in first‐trimester selective screening for gestational diabetes mellitus: a prospective population‐based multicentre cohort study

Early triglyceride and glucose index as a risk marker for gestational diabetes mellitus

First Trimester Glycated Hemoglobin (HBA1C) Level as a Novel Predictor of Gestational Diabetes Mellitus: a Systematic Review and Meta-Analysis

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