Maternal Serum Eye Drops in the Management of Pediatric Persistent Corneal Epithelial Defects: A Case Series

Kalhorn, Ashton J.; Tawse, Kirstin; Shah, A.; Jung, Jennifer; Gregory, Darren G.; McCourt, Emily A.

doi:10.1097/ico.0000000000001512

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…[ 13 ] When present, neurotrophic epithelial defects and ulcers have been treated with lubricating ointments, soft contact lenses, maternal serum eyedrops amniotic membrane transplantation, and other surgical approaches. [ 6 , 7 ] However, these conditions are frequently associated with poor visual outcomes, and the management requires long-term efforts with multiple treatments, especially in pediatric patients. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 , 7 ] However, these conditions are frequently associated with poor visual outcomes, and the management requires long-term efforts with multiple treatments, especially in pediatric patients. [ 6 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] Further therapeutic strategies include contact lenses’ use, amniotic membrane transplantation, conjunctival flap transposition, tarsorrhaphy, and corneal surgery. [ 4 , 6 , 7 ] Human recombinant nerve growth factor (hrNGF) has been recently approved as the specific topical treatment for NK because of its potential to target the underlying nerve deficit. [ 3 , 8 , 9 ]…”

Section: Introductionmentioning

confidence: 99%

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A case report of pediatric neurotrophic keratopathy in pontine tegmental cap dysplasia treated with cenegermin eye drops

et al. 2020

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Rationale: To report the management of recalcitrant neurotrophic keratopathy in a pediatric patient affected by pontine tegmental cap dysplasia (PTCD) using topical human recombinant nerve growth factor (hrNGF, Cenegermin 20 μg/ml). To the best of our knowledge the present case is one of the few described in patients with congenital NK treated with Cenegermin, and the first in a patient affected by PTCD. Patient Concerns: A 9-year-old patient, affected by PTCD with bilateral cranial nerve V 1 and VIII palsies, was referred to our hospital for visual disturbances and redness of the right eye due to persistent neurotrophic epithelial defect. The patient presented marked developmental delay, ataxia, bilateral hypoacusia, and bilateral corneal severe hypoaesthesia. Ocular history revealed multiple treatments in order to treat neurotrophic ulcer in the left eye. Four years later, he developed a persistent epithelial defect with corneal anesthesia in the right eye. Diagnoses: The impaired trigeminal nerve function, due to the underlying congenital disease, led to the development of moderate NK (stage II) in the right eye and a mild NK (stage I) in the left eye. Interventions: Cenegermin 20 μg/ml eye-drop was administered in both eyes. Treatment was continued for 8 weeks. The patient was assessed after 4 and 8 week of treatment. At each follow-up visit, treatment efficacy and adverse events were evaluated. Outcomes: The use of Cenegermin eye drops facilitated the remarkable resolution of the neurotrophic keratopathy and the improvement of corneal sensitivity in both eyes. No local or systemic adverse events were observed. Lessons: Topical Cenegermin 20 μg/ml was well-tolerated and may represent a valuable therapeutic option in the management of pediatric neurotrophic keratopathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case report of pediatric neurotrophic keratopathy in pontine tegmental cap dysplasia treated with cenegermin eye drops

et al. 2020

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“…Pontine tegmental cap dysplasia (PTCD) is a rare neurological syndrome with a distinct hindbrain malformation and cranial nerve (CN) dysfunction [1]. Approximately 40 cases have been reported [1], [2], [3], [4], [5], [6], [7], [8]. Magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) plays an essential role in diagnosing PTCD [9].…”

Section: Introductionmentioning

confidence: 99%

“…Varying deficits in CN V, VI, VII, VIII, and IX [1] are known. The symptoms vary in scope and severity among patients ranging from mild cognitive impairment to severe dysfunction, but most patients present with deafness and speech difficulty [1], [2], [3], [4], [5], [6], [7], [8], [9], [10].…”

Section: Introductionmentioning

confidence: 99%

Pontine tegmental cap dysplasia with a duplicated internal auditory canal

Chan¹,

Veltkamp²,

Desai³

et al. 2019

Radiology Case Reports

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Pontine tegmental cap dysplasia (PTCD) is a rare neurological syndrome that results in a hypoplastic ventral pons, tegmental cap at the dorsal pons, and cranial nerve dysfunction. The most common symptoms are hearing loss and speech problems. We present a case of a 9-month-old male who presented with developmental delay and hypotonia. Magnetic resonance imaging revealed ectopic dorsal transverse pontine fibers and a cap-like protrusion of the dorsal pons. Diffusion tensor imaging showed that the ventral pontine fibers were absent. The cause of PTCD is undiscovered, but proposed hypotheses include dysfunction in axonal guidance, neuronal migration, and ciliary protein function. PTCD is a rare neurological disorder, but the diagnosis can be suggested with MRI using diffusion tensor imaging as an aid.

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Pediatric Neurotrophic Keratopathy

Chea,

Zeidenweber,

Fung

2023

Pediatric Ocular Surface Disease

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Maternal Serum Eye Drops in the Management of Pediatric Persistent Corneal Epithelial Defects: A Case Series

Abstract: Maternal serum eye drops are a well-tolerated and potentially beneficial addition to the management of pediatric persistent corneal epithelial defects.

Cited by 8 publications

References 8 publications

A case report of pediatric neurotrophic keratopathy in pontine tegmental cap dysplasia treated with cenegermin eye drops

A case report of pediatric neurotrophic keratopathy in pontine tegmental cap dysplasia treated with cenegermin eye drops

Pontine tegmental cap dysplasia with a duplicated internal auditory canal

Pediatric Neurotrophic Keratopathy

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