Maternal serum endothelial cell-specific molecule-1 level and its correlation with severity of early-onset preeclampsia

Ovayolu, Ali; Karaman, Erbil; Turgut, Abdülkadir; Güler, Selver; Bostancıeri, Nuray

doi:10.1080/01443615.2020.1819215

Cited by 2 publications

(4 citation statements)

References 25 publications

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“…36 The same study also showed that endocan was not influenced by obesity, which is consistent with our results. 36 Considering our study and these studies, it is clear that the role of endocan in ED needs to be supported by more studies. Thickening of the intima-media layer is a primary indicator of arterial damage and precedes plaque formation.…”

Section: Discussionsupporting

confidence: 91%

“…34,35 However, Ovayolu et al showed that serum endocan levels were not elevated in early preeclampsia compared with healthy pregnant women. 36 The same study also showed that endocan was not influenced by obesity, which is consistent with our results. 36 Considering our study and these studies, it is clear that the role of endocan in ED needs to be supported by more studies.…”

Section: Discussionsupporting

confidence: 91%

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Relationship Between Serum Endocan Levels and Other Predictors of Endothelial Dysfunction in Obese Women

Mercantepe

Şahin²,

Cüre

et al. 2022

Angiology

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Endocan, or endothelial cell-specific molecule-1 (ESM-1), is a potential inflammatory marker implicated in endothelial dysfunction. The purpose of this study was to determine the correlation between serum endocan levels and the presence and severity of endothelial dysfunction, and the relationships with serum intracellular adhesion molecule-1 (ICAM-1), adiponectin (a marker of inflammation), high sensitivity C-reactive protein (hsCRP) levels, and carotid intima-media thickness (cIMT) in obese subjects. Serum endocan, ICAM-1, adiponectin, hsCRP levels, and cIMT were evaluated in 76 obese women (BMI > 30 kg/m2) and 53 controls (BMI < 25 kg/m2). ICAM-1 ( P = .01), hs-CRP (p < 0.001), and cIMT ( p < .001) were significantly higher, while adiponectin ( P = .006) was significantly lower, in obese women compared with the controls. Serum endocan levels were similar between the obese (470.5 ± 171.3 pg/mL) and controls (471.9 ± 146.3 pg/mL) ( P = .732). There was no correlation between serum endocan values and the endothelial dysfunction markers, hsCRP (r = −.021), ICAM-1 (r = −.054), adiponectin (r = .113), or cIMT (r = −.060) in obesity. Endocan is not a suitable marker of endothelial dysfunction in the context of obesity. More research is required to evaluate the role of endocan in the regulation of inflammatory processes in obesity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

Relationship Between Serum Endocan Levels and Other Predictors of Endothelial Dysfunction in Obese Women

Mercantepe

Şahin²,

Cüre

et al. 2022

Angiology

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“…In the literature, recent studies showed that endocan values were affected in many diseases such as kidney diseases, 38 T2DM, 39,40 preterm premature rupture of membrane, 41 preeclampsia, 42 non-alcoholic fatty liver F I G U R E 1 The discriminative value of endocan for patients with gestational diabetes mellitus (GDM) using receiver operating curve (ROC) analysis.…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, recent studies showed that endocan values were affected in many diseases such as kidney diseases, 38 T2DM, 39,40 preterm premature rupture of membrane, 41 preeclampsia, 42 non‐alcoholic fatty liver disease, 43 cancer, 44 periodontal disease, 45 and human obesity 46 in which vascular angiogenesis, endothelial dysfunction, and inflammation was claimed to be the underlying pathophysiology. The fact is that endocan is an important biomodulator that presents in complicated pregnancies, probably due to the potential role of regulating insulin resistance, like the association shown with T2DM formerly.…”

Section: Discussionmentioning

confidence: 99%

Is maternal serum endocan level a novel marker in gestational diabetes mellitus?

Yıldız

Gencer

Timur

et al. 2023

J of Obstet and Gynaecol

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AimTo determine whether there was a significant difference between serum endocan levels of pregnant women with and without gestational diabetes mellitus (GDM).MethodsA total of 90 pregnant women, 45 with gestational diabetes and 45 healthy pregnant women, between 24 and 28 gestational weeks, were included in this prospective case–control study. The pregnant women were screened for gestational diabetes using a two‐step protocol. Serum endocan levels were measured using a commercially available enzyme‐linked immunosorbent assay (ELISA) kit. A p‐value of <0.05 was considered statistically significant.ResultsSerum endocan level was significantly higher in the GDM group than in healthy controls (168.46 ± 160.6 vs. 105.66 ± 26.52 pg/mL, respectively; p < 0.001). Serum endocan concentrations were positively correlated with the results of 50 g oral glucose challenge test (GCT) (p < 0.001). Receiver operating characteristic curve analysis showed that endocan with a cut‐off point of 133.9 ng/dL indicated women with GDM with a sensitivity of 55.6% and specificity of 88.9% (area under the curve [AUC]: 0.737, 95% CI: 0.634–0.824). The overall differential performance of endocan according to the GDM groups was determined as 73.7% (p < 0.001). Maternal serum endocan level was positively correlated with fasting glucose, postprandial glucose, and glycated hemoglobin (HbA1c) (p < 0.001).ConclusionsElevated endocan levels in gestational diabetes were correlated with fasting glucose, postprandial glucose, HbA1c, and oral glucose tolerance test (OGTT) results. Despite the low sensitivity of 55.6% and the high specificity of 88.9%, we found a high differential performance rate indicating that serum endocan levels were important for the pathophysiology of GDM and should be investigated for the possibility of being a novel marker in larger populations.

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Maternal serum endothelial cell-specific molecule-1 level and its correlation with severity of early-onset preeclampsia

Cited by 2 publications

References 25 publications

Relationship Between Serum Endocan Levels and Other Predictors of Endothelial Dysfunction in Obese Women

Relationship Between Serum Endocan Levels and Other Predictors of Endothelial Dysfunction in Obese Women

Is maternal serum endocan level a novel marker in gestational diabetes mellitus?

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