Maternal serum creatine kinase as a biochemical marker of tubal pregnancy

Chandra, Lal; Jain, Anju

doi:10.1016/0020-7292(95)02340-i

Cited by 21 publications

(20 citation statements)

References 3 publications

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“…13 Lavie et al, Chandra et al and Saha et al also found the mean Cpk levels of ectopic pregnancies to be significantly higher than the control groups. [4][5][6] In present study, the CPK levels were compared between ruptured and unruptured tubal ectopics and the mean CPK levels in ruptured (97.26±25.97) were higher than unruptured (63.82±34.92) which was statistically significant(p=0.015). However, studies with large study population are required to further validate the findings.…”

Section: Discussionmentioning

confidence: 70%

“…Subsequently Chandra et al, Saha PK and others have confirmed CPK as a possible marker but Kurzel had differing results. [5][6][7] Early diagnosis is critical in bringing down the maternal mortality and morbidity. Ectopic pregnancy continues to be a diagnostic challenge to the obsteriticans, hence in our quest to find a marker we studied the role of CPK, which along with β-hCG and TVS can help us to clinch the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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CPK: The new tool in the diagnosis of ectopic pregnancy

Ganta

Kulkarni

Muralidhar

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Ectopic pregnancy is still a diagnostic dilemma presenting with various complaints. The classic triad of amenorrhea, abdominal pain, vaginal bleeding and /or syncope is not always seen. Misdiagnosis can lead to delay in treatment, blood loss is found to be the major cause of death. Early and accurate diagnosis is critical in bringing down the maternal mortality and morbidity. Prompt and effective treatment of an ectopic pregnancy can help preserve the chances of future healthy pregnancies. Aim of present study was to investigate whether creatinine phosphokinase (cpk) can be used as an effective diagnostic tool in the early diagnosis of ectopic pregnancy which can help in decreasing the maternal mortality and morbidityMethods: This observational comparative three group clinical study was conducted at Chinmaya Mission Hospital, Bangalore, between May 2016 to January 2017.120 women in their early trimester were studied of which 40 were diagnosed cases of ectopic pregnancies, 40 women presented with intrauterine abortive pregnancies and 40 women had normal healthy pregnancies. Serum CPK, serum B-HCG, vaginal scans were done in all, along with routine investigations.Results: The mean CPK values in normal, abortive and ectopic pregnancies were 36.92±6.44, 43.95±11.96 and 91.55±30.43 respectively. It was found to be significantly higher in ectopic Pregnancies. Also, the mean CPK in ruptured and unruptured ectopic pregnancy were 97.26±25.97 and 63.82±34.92 respectively.Conclusions: Present study shows that maternal CPK levels are significantly higher in women with ectopic pregnancies. CPK can serve as the reliable biochemical marker to diagnose ectopic pregnancy particularly ruptured. CPK can be used to increase the diagnostic efficacy in ectopic pregnancy, which followed by rapid and appropriate treatment can reduce the mortality, morbidity and preserve future fertility.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

CPK: The new tool in the diagnosis of ectopic pregnancy

Ganta

Kulkarni

Muralidhar

2017

Int J Reprod Contracept Obstet Gynecol

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“…Obstetricsmuscle cell products such as CK to enter the circulation [67]. Consequently, increased serum CK activity is normal during EP [67].…”

Section: Serum Creatine Kinase (Ck) Concentrationmentioning

confidence: 99%

“…Consequently, increased serum CK activity is normal during EP [67]. Saha et al [68] carried out a study involving 40 women, and the total serum CK activity was found to be greater in the EP group compared to the controls, suggesting that this test might be an indicator for EP.…”

Section: Serum Creatine Kinase (Ck) Concentrationmentioning

confidence: 99%

Ectopic Pregnancy: Diagnosis, Prevention and Management

Abdulkareem¹,

Eidan²

2017

Obstetrics

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An ectopic pregnancy (EP) falls within the area of the gynecological emergency and/or reproductive management of women, which is the implantation of fertilized ovum outside the endometrial cavity. The etiology of EP concentrated mainly on factor causes delayed transport of the fertilized ovum through the fallopian tube (favors implantation in tubal mucosa), thus giving rise to EP. This chapter describes the causes, diagnosis, prevention and the guidelines to improve the management of women who may have an EP, a major gynecological emergency that is a cause of morbidity or even mortality of women in first trimester. Three types of EP are diagnosed: tubal, cervical and ovarian; tubal is the main type. Identification of the signs and symptoms of acute and chronic EP in women, involving classical clinical trials or other symptoms common to early pregnancy, as well as evaluating the most important congenital and acquired factors related with EP, were discussed. Explanation of the most accurate methods used to diagnose the pregnancy including serum beta hCG and progesterone levels, medical history, ultrasonography, pregnancy tests and laparoscopy was also clarified. The evaluation of the most effective management tools of EP, including methotrexate administration and surgery (laparotomy and laparoscopy), was obviously explained.

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“…Although an increase of CPK concentration reflects injury to a tissue, the diagnostic value of CPK level in ectopic pregnancy remains uncertain. While Lavie et al [6] reported that serum CPK level has an important diagnostic role in the evaluation of a suspected tubal pregnancy, subsequent studies yielded conflicting results [3,[7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%