Maternal serum corticotropin-releasing hormone at midgestation in hispanic and white women

Siler-Khodr, Theresa M.; Forthman, G; Khodr, Christina E.; Matyszczyk, S.; Khodr, Zeina G.; Khodr, Gabriel S.

doi:10.1016/s0029-7844(02)03072-7

Cited by 17 publications

(11 citation statements)

References 34 publications

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“…Other studies have reported higher CRH in whites than Hispanics (32) and three studies have reported higher CRH levels in whites than Blacks (10, 18, 41). One study also reported lower levels of pregnancy CRH in Hispanics than Blacks (41).…”

Section: Discussionmentioning

confidence: 91%

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Cumulative stress and maternal prenatal corticotropin-releasing hormone in an urban U.S. cohort

Tse¹,

Rich‐Edwards²,

Koenen³

et al. 2012

Psychoneuroendocrinology

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Background To date, there have been conflicting reports of the association of psychosocial stressors with prenatal corticotropin-releasing hormone (CRH) levels. Methods We examined whether racial discrimination, community violence, interpersonal violence (IPV), negative life events, considered independently, and as a composite measure of cumulative stress, were associated with prenatal CRH levels in the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project, a multiethnic pre-birth cohort in urban Boston. Blood was collected between 20 and 37 weeks gestation (Mean = 28.1, SD = 4.6 weeks gestation). During pregnancy, women were administered the Conflict Tactics Scale survey to assess IPV, the Crisis in Family Systems-Revised survey to assess negative life events, the My Exposure to Violence survey to assess community violence, and the Experiences of Discrimination survey. A cumulative stress measure was derived from these instruments to characterize exposure to high levels of multiple stressors. Results None of the individual stressors or cumulative stress was associated with CRH in combined analyses including Whites (n=20), Blacks (n=46), and Hispanics (n=110). In separate analyses of Blacks and Hispanics, racial discrimination, community violence, and cumulative stress were associated with CRH in Blacks, but were not associated with CRH in Hispanics. Conclusions Though these results require replication, they suggest that the effects of stress on prenatal CRH levels may be mediated by factors that differ between racial/ethnic groups. Further studies in larger samples are warranted to clarify whether associations of chronic stressors and prenatal CRH levels differ by race/ethnicity and to better understand underlying mechanisms.

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Section: Discussionmentioning

confidence: 91%

“…The samples were cooled, centrifuged and stored at −70 C degrees. Briefly, either 150 ul (for <33 weeks since last menstrual period, LMP) or 40 ul (for ≥33 weeks since LMP) was extracted with a final concentration of 87.5% methanol and was assayed using previously described methods (10, 32). Assay sensitivity was 10.8 pg/ml.…”

Section: Methodsmentioning

confidence: 99%

Cumulative stress and maternal prenatal corticotropin-releasing hormone in an urban U.S. cohort

Tse¹,

Rich‐Edwards²,

Koenen³

et al. 2012

Psychoneuroendocrinology

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“…loss of appetite) may lead to growth restriction. As research suggests the possibility of differences in HPA axis function and the prevalence of health risk behaviors during pregnancy by race/ethnicity (Glynn et al 2007; Chen et al 2010; Siler Khodr et al 2003; Field et al 2002), it is important that further research considers these possible differences when examining potential mechanisms leading to disparities in adverse birth outcomes.…”

Section: Discussionmentioning

confidence: 99%

Depression During Pregnancy and Adverse Birth Outcomes Among Predominantly Puerto Rican Women

Szegda

Bertone‐Johnson

Pekow

et al. 2016

Matern Child Health J

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Objectives To examine associations between depression and preterm birth and small-for gestational age (SGA) among women of predominantly Puerto Rican descent, a population who experiences disparities in adverse birth outcomes and one of the highest infant mortality rates in the United States. Methods Proyecto Buena Salud (PBS) was a prospective cohort study conducted from 2006 to 2011 at a large tertiary care center in Western Massachusetts. Caribbean Islander (i.e., Puerto Rican and Dominican Republic) women were interviewed in early, mid and late pregnancy. Among 1262 participants, associations between depression, assessed using the Edinburgh Postnatal Depression Scale, and risk of preterm birth and small-for-gestational age (SGA) were evaluated. Results Women with at least probable minor depression [odds ratio (OR) = 1.77 (95% confidence interval (CI) = 1.02, 3.07)] or probable major depression [OR = 1.82 (95% CI = 1.01, 3.25)] in mid-pregnancy had an increased risk of SGA compared to non-depressed women in adjusted analyses. Borderline significant associations were observed between increasing levels of depressive symptom scores in early and mid-pregnancy [OR = 1.05 (95% CI = 1.00, 1.11) and OR = 1.04 (95% CI = 1.00, 1.09), respectively] and each additional trimester of exposure to probable major depression across mid- to late pregnancy [OR = 1.66 (95% CI = 1.00, 2.74)] and SGA. Late pregnancy depression was not associated with SGA; depression during pregnancy was not associated with preterm birth. Conclusions for Practice In this population of predominantly Puerto Rican women, mid-pregnancy depression increased risk for SGA. Findings can inform culturally appropriate, targeted interventions to identify and treat pregnant women with depression.

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“…During mid-gestation there is a rapid increase in the concentration of CRH in the maternal plasma (38). This occurs alongside production of surfactant in the fetal human lung beginning after week 24 of gestation, which corresponds to the saccular stage of lung development and the earliest consistently documented threshold of viability.…”

Section: Discussionmentioning

confidence: 99%

Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome–associated neonatal lethality in Erk3−/− mouse pups

et al. 2014

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BACKGROUND Respiratory distress syndrome (RDS) persists as a prevalent cause of infant morbidity and mortality. We have previously demonstrated that deletion of Erk3 results in pulmonary immaturity and neonatal lethality. Using RNA-Seq, we identified corticotrophin releasing hormone (CRH) and surfactant protein B (SFTPB) as potential molecular mediators of Erk3-dependent lung maturation. In this study, we characterized the impact of antenatal glucocorticoids and postnatal surfactant on neonatal survival of Erk3 null mice. METHODS In a double crossover design, we administered dexamethasone (dex) or saline to pregnant dams during the saccular stage of lung development, followed by postnatal surfactant or saline via inhalation intubation. Survival was recorded, detailed lung histological analysis and staining for CRH and SFTPB protein expression was performed. RESULTS Without treatment, Erk3 null pups die within 6 hours of birth with reduced aerated space, impaired thinning of the alveolar septa, and abundant PAS-positive glycogen stores; as described in human RDS. The administration of dex and surfactant improved RDS-associated lethality of Erk3−/− pups, and partially restored functional fetal lung maturation by accelerating the down-regulation of pulmonary CRH and partially rescuing production of SFTPB. CONCLUSION These findings emphasize that Erk3 is integral to terminal differentiation of type II cells, SFTPB production, and fetal pulmonary maturity.

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Maternal serum corticotropin-releasing hormone at midgestation in hispanic and white women

Cited by 17 publications

References 34 publications

Cumulative stress and maternal prenatal corticotropin-releasing hormone in an urban U.S. cohort

Cumulative stress and maternal prenatal corticotropin-releasing hormone in an urban U.S. cohort

Depression During Pregnancy and Adverse Birth Outcomes Among Predominantly Puerto Rican Women

Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome–associated neonatal lethality in Erk3−/− mouse pups

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