Maternal serum calprotectin level in intrahepatic cholestasis of pregnancy

Agaoglu, Recep Taha; Çelik, Özge; Yakut, Kadriye; Çelen, Şevki; Çağlar, Ali Turhan

doi:10.1111/jog.14925

Cited by 4 publications

(2 citation statements)

References 44 publications

(133 reference statements)

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“…30,31 In another recent study supporting the inflammatory process in the pathogenesis of ICP, maternal serum calprotectin levels, a marker of inflammatory disorders, were found to be higher in patients with ICP than in healthy pregnant women. 32 DNI is a new inflammatory marker which is calculated by using the following formula: DNI (%) = (the leukocyte subfraction assayed in the MPO channel by cytochemical reaction) À (the leukocyte subfraction assayed using the nuclear lobularity channel by reflected light beam measurements) with a flow cytometry-based hematologic analyzer. 33,34 In recent years, many studies have been conducted on DNI as an inflammatory biomarker.…”

Section: Discussionmentioning

confidence: 99%

Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy

Eroğlu

Uysal

Sarsmaz

et al. 2021

J of Obstet and Gynaecol

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Objective: This study aims to compare the maternal serum delta neutrophil index (DNI) levels in intrahepatic cholestasis of pregnancy (ICP) and healthy pregnancies. Methods: This study consisted of a group of patients (n = 40) diagnosed with isolated ICP who gave birth in our hospital and a control group (n = 60) between December 1, 2015, and June 30, 2018. The diagnosis of ICP was made based on pruritus and elevated fasting serum bile acids and liver enzymes. Laboratory tests of both groups in the hospitalization process were retrospectively examined. Maternal and neonatal characteristics, pregnancy outcomes, and DNI values of the two groups were compared. Statistical analyses were performed using SPSS version 20. Results: Mean maternal serum DNI levels were significantly higher in women with ICP than in the control group (0.49 AE 4.8 vs -3.99 AE 3.02, p = <0.01). Receiver operating characteristic (ROC) curve analysis was used to define the DNI value where ICP can be best predicted. Conclusion: DNI, a new inflammatory marker, was found to be higher in women with ICP than in normal pregnancies.

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Section: Discussionmentioning

confidence: 99%

Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy

Eroğlu

Uysal

Sarsmaz

et al. 2021

J of Obstet and Gynaecol

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“…Elevated levels of LFTs, namely transaminases, are a very common (17–80%) [ 1 , 44 , 56 ] finding in patients with ICP, with mean values of 148 IU/L for ALT and 105 IU/L for AST in >2000 patients with ICP [ 53 ] (range of 1.5–8-fold increase × ULN) [ 44 ]. However, elevated LFTs are not considered a diagnostic criterion anymore [ 51 ], especially because they do not correlate with ICP severity and bear limited prognostic significance, if any at all.…”

Section: Pregnancy-related Liver Disordersmentioning

confidence: 99%

Diagnostic Approach to Elevated Liver Function Tests during Pregnancy: A Pragmatic Narrative Review

Dajti,

Bruni,

Barbara

et al. 2023

JPM

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Liver disease is not uncommon during pregnancy and is associated with increased maternal and fetal/neonatal morbidity and mortality. Physiological changes during pregnancy, including a hyperestrogenic state, increase in circulating plasma volume and/or reduction in splanchnic vascular resistance, and hemostatic imbalance, may mimic or worsen liver disease. For the clinician, it is important to distinguish among the first presentation or exacerbation of chronic liver disease, acute liver disease non-specific to pregnancy, and pregnancy-specific liver disease. This last group classically includes conditions such as hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, liver disorders associated with the pre-eclampsia spectrum, and an acute fatty liver of pregnancy. All of these disorders often share pathophysiological mechanisms, symptoms, and laboratory findings (such as elevated liver enzymes), but a prompt and correct diagnosis is fundamental to guide obstetric conduct, reduce morbidity and mortality, and inform upon the risk of recurrence or development of other chronic diseases later on in life. Finally, the cause of elevated liver enzymes during pregnancy is unclear in up to 30–40% of the cases, and yet, little is known on the causes and mechanisms underlying these alterations, or whether these findings are associated with worse maternal/fetal outcomes. In this narrative review, we aimed to summarize pragmatically the diagnostic work-up and the management of subjects with elevated liver enzymes during pregnancy.

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A Comprehensive Review of Novel Biomarkers in the Diagnosis of Intrahepatic Cholestasis of Pregnancy

Liu,

Chen,

Wang

et al. 2023

Biomark. Med.

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Intrahepatic cholestasis of pregnancy (ICP) is a disease specific to pregnancy, featuring maternal itching and elevated serum bile acid levels. It leads to a series of adverse pregnancy outcomes as well as increased fetal mortality. Routine biochemical markers fail to fulfill the tremendous clinical requirements, thereby novel effective biomarkers are urgently desired. In our review, the potential novel biomarkers for ICP diagnosis are classified into four categories and elaborated in detail. The concrete diagnostic performances (sensitivity, specificity and area under the curve) of these biomarkers are demonstrated in tables. Moreover, the relationships between some biomarkers and ICP pathogenesis are briefly expounded. Nevertheless, only a few novel biomarkers are ideal, and their clinical applicability requires more evidence from larger multicenter trials.

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Maternal serum calprotectin level in intrahepatic cholestasis of pregnancy

Cited by 4 publications

References 44 publications

Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy

Increased serum delta neutrophil index levels are associated with intrahepatic cholestasis of pregnancy

Diagnostic Approach to Elevated Liver Function Tests during Pregnancy: A Pragmatic Narrative Review

A Comprehensive Review of Novel Biomarkers in the Diagnosis of Intrahepatic Cholestasis of Pregnancy

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