Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight

Öktem, Özgür; Dedeoglu, Nihan; Oymak, Yüksel; Sezen, Devrim; Köksal, Leyla; Pekin, Tanju; Gökaslan, Hüsnü; Kavak, Zehra Neşe

doi:10.1515/jpm.2004.050

Cited by 16 publications

(19 citation statements)

References 54 publications

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“…Oktem et al investigated the relationship between fetal weight and leptin levels in maternal serum, amniotic fluid and the umbilical cord. 26 The authors reported that, whereas cord leptin level correlated with birth weight and placental weight, AFL did not correlate with birth weight, consistent with our findings. However, both studies may have been underpowered to detect this relationship.…”

Section: Discussionsupporting

confidence: 91%

Standardization of amniotic fluid leptin levels and utility in maternal overweight and fetal undergrowth

et al. 2015

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Section: Discussionsupporting

confidence: 91%

Standardization of amniotic fluid leptin levels and utility in maternal overweight and fetal undergrowth

et al. 2015

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“…The functional role of placental leptin remains to be fully established, but it is certainly important since it is one of the major sources of leptin in fetal circulation [21] . However, in our experience there was no correlation between amniotic leptin levels and fetal birth weight, confirming previous reports [8,22,23] but disagreeing with others [12,14,24] in which an inverse correlation has been found.…”

Section: Discussionsupporting

confidence: 60%

Midtrimester Amniotic Fluid Leptin and Insulin Levels and Subsequent Gestational Diabetes

D’Anna¹,

Baviera²,

Cannata³

et al. 2007

Gynecol Obstet Invest

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Aims: To evaluate midtrimester amniotic fluid leptin levels in pregnancies subsequently complicated by gestational diabetes. Methods: We studied 32 pregnant women with gestational diabetes and a control group of 43 normal pregnancies with an adequate gestational age fetus. All underwent a midtrimester amniocentesis: leptin and insulin were measured in the amniotic fluid. Data were compared with the Mann-Whitney U-test. Results: Median leptin concentrations in the amniotic fluid of the gestational diabetes mellitus patients were significantly higher than in the control group (15.1 vs. 7.9 ng/ml) (p = 0.001); amniotic insulin concentrations were also higher in the gestational diabetes mellitus than in the control group (0.67 vs. 0.38 µU/ml) (p = 0.02). Furthermore, amniotic fluid leptin levels were directly correlated with amniotic insulin concentrations; instead, there was no correlation with maternal BMI and birth weight. Conclusion: Our data suggest that in pregnancies subsequently complicated by gestational diabetes, amniotic fluid leptin and insulin levels are higher in the early fetal period.

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“…Of these, 34 were excluded resulting in 40 studies consistent with the criteria set for the meta‐analysis 20–59 . In addition, four studies 60–63 were identified through hand search of the reference lists of the retrieved articles, resulting in the final number of 44 articles included in the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…The average sample size of these 44 studies was 119.3 neonates (range 22–585). Considering the assay used for the measurement of cord leptin, 35 studies employed radioimmunoassay (RIA), 21–24,28–31,34–43,46–61,63 while seven studies used ELISA 20,26,27,32,33,44,62 and two others used a two‐site immunoradiometric assay (IRMA) 25,45 . In six studies, 21,35,38,50,52,63 log leptin was used for the estimation of the level of association; these studies were analysed separately.…”

Section: Resultsmentioning

confidence: 99%

Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta‐analysis

Karakosta¹,

Chatzi²,

Plana

et al. 2010

Paediatric Perinatal Epid

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The role of intrauterine environment in the development of obesity is increasingly recognised. Adipokines and specifically leptin have been examined as potential biomarkers predicting early development of obesity. We conducted a systematic review and meta-analysis of the epidemiological evidence for the association between leptin levels in cord blood and anthropometric measurements at birth in healthy mother-newborn pairs. A PubMed search was performed between 1994 and 2009 and manual search of reference lists of retrieved articles. Forty-four studies met the inclusion criteria set. All studies reported a positive correlation between leptin levels and birthweight. The combined correlation coefficient (r) was 0.46 [95%CI 0.43, 0.50]. Leptin levels explained 21% of variation in birthweight. Results were similar in males (r=0.55; 0.40, 0.68) and females (r=0.60; 0.50, 0.69), and between Caucasians (r=0.45; 0.39, 0.51) and eastern Asian populations (r=0.47; 0.37, 0.55). Statistically significant positive correlations were also found for birth length (r=0.29; 0.23, 0.34) and ponderal index (r=0.36; 0.31, 0.41). There was no indication of publication bias (Egger's test P-value=0.23). This meta-analysis shows a clear but moderate correlation between leptin levels in cord blood and birthweight that is observed in different population groups.

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Maternal serum, amniotic fluid and cord leptin levels at term: their correlations with fetal weight

Cited by 16 publications

References 54 publications

Standardization of amniotic fluid leptin levels and utility in maternal overweight and fetal undergrowth

Standardization of amniotic fluid leptin levels and utility in maternal overweight and fetal undergrowth

Midtrimester Amniotic Fluid Leptin and Insulin Levels and Subsequent Gestational Diabetes

Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta‐analysis

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