Maternal serum 25(OH)D levels in the third trimester of pregnancy during the winter season

Üstüner, İşık; Keskin, Hüseyin Levent; Taş, Emre Erdem; Neşeli̇oğlu, Salim; Şengül, Özlem; Avşar, Ayşe Filiz

doi:10.3109/14767058.2011.566768

Cited by 23 publications

(20 citation statements)

References 20 publications

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“…Higher rates of severe vitamin D deficiency were previously reported in the literature from Turkey 10,17 . Those prior studies have shown that covered dress style may be an important factor affecting the prevalence of vitamin D deficiency in Muslim populations due to the religious and cultural reasons 10,18. The prevalence of low vitamin D levels was greater in cases which were sampled in winter, in women who had limited access to sunlight, those living in countries at higher latitudes and those with higher skin pigmentation 16,[18][19][20] .…”

Section: Discussionsupporting

confidence: 60%

Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

Ates¹,

Şevket²,

Özcan³

et al. 2016

Afr H. Sci.

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Objective: To assess serum levels of in the first trimester and to determine the factors affecting deficiency levels and its association with pregnancy outcomes. Methods: Serum 25(OH)D concentrations were measured at 11-14 weeks' gestation in 229 singleton pregnancies using liquid chromatography-tandem mass spectrometry. Results: The median serum 25(OH)D concentration was 10.8 ng/mL and 45.9% of women had severe vitamin D deficiency with concentrations of <10 ng/mL. Logistic regression analysis revealed that covered dressing style, lack of multivitamin intake, season of blood sampling (November-April) were factors associated with 25(OH)D deficiency. There was a negative correlation between 25(OH)D levels and gestational age at sampling. Low 25(OH)D levels were not associated with adverse pregnancy outcomes. Higher rate of cesarean section (CS) was noted in women with 25(OH)D ≥10 ng/mL compared to those with 25(OH)D < 10mg/ml ( p= 0.01). Conclusion: A high prevalence of vitamin D deficiency was observed in early pregnancy which was related to dress code, use of multi-vitamins and season at sampling. Low 25(OH)D levels were not related with adverse pregnancy outcomes. Women with severe vitamin D deficiency were more likely to deliver vaginally.

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Section: Discussionsupporting

confidence: 60%

Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

Ates¹,

Şevket²,

Özcan³

et al. 2016

Afr H. Sci.

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“…In a study by Zhao et al (25), the mean level of 25(OH)D in the second trimester was significantly higher than the one in the first trimester and equivalent to the one in the third trimester. Our results are compatible with the recent study which reported high prevalence of severe vitamin D deficiency [25(OH) D<10 ng/mL] (45.6%) among pregnant women in Turkey (26). These findings indicate that vitamin D deficiency is a major health problem in our population as well.…”

Section: Discussionsupporting

confidence: 83%

Association Between Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus in Pregnant Women

Ates¹,

Aydın²,

Karasu³

et al. 2017

Haseki

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Methods:We conducted a cross-sectional study of a cohort of pregnant women who had undergone routine genetic multiple marker screening and subsequent glucose tolerance testing. Twenty-five women with GDM and 208 controls without GDM were included in this study. Plasma 25(OH)D concentrations were measured using liquid chromatography-tandem mass spectrometry.Results: Mean 25(OH)D concentrations at 11-14 weeks of gestation were not significantly different in women who subsequently developed GDM compared with those who did not (mean ± standard deviation: 13.96 9.05 versus 13.43±9.72; p=0.8). The prevalence of first-trimester severe 25(OH)D deficiency (<10 ng/mL) was similar between women with GDM and healthy controls (44% vs. 44.7%, respectively; p=0.9). The mean concentration of 25(OH)D slightly increased over the two gestational age windows both in women with GDM [mean ∆25(OH)D: 0.25±5.8 ng/mL] and controls [mean ∆25(OH)D: 0.84±12.84 ng/mL], but the difference was not statistically significant (p=0.8). Conclusion:Vitamin

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“…Maternal vitamin D deficiency is common during pregnancy and a widespread public health problem 6 . A high prevalence of vitamin D deficiency has been observed among pregnant women, 7 with prevalence rates varying by ethnicity 8 and sunlight exposure 9 . There is increasing interest in a range of actions of vitamin D in pregnancy, including its effects on placental function and inflammatory response 10 .…”

Section: Introductionmentioning

confidence: 99%

Longitudinal vitamin D status in pregnancy and the risk of pre‐eclampsia

Wei

Audibert

Hidiroglou

et al. 2012

BJOG

159

120

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Objective Whether vitamin D deficiency in pregnancy is a cause of pre-eclampsia remains controversial. Most previous studies to date have assessed exposure at only one time-point in pregnancy.We assessed longitudinal vitamin D status during pregnancy and the risk of pre-eclampsia.Design Prospective cohort study.Setting Seventeen urban obstetric hospitals, Canada.Population Pregnant women who were participants in a trial of vitamin C and E supplementation for the prevention of preeclampsia. Canadian participants who consented to participate in a biobank with plasma specimens available at the baseline visit were included (n = 697).Methods Maternal plasma 25-hydroxyvitamin D (25(OH)D) concentrations were measured at 12-18 and 24-26 weeks of gestation using chemiluminescence immunoassay.Main outcome measures Pre-eclampsia.Results Of the women, 39% were vitamin D deficient (25(OH)D <50 nmol/l). A strong positive correlation was observed in maternal 25(OH)D concentrations between the two gestational age windows (r = 0.69, P < 0.0001). Mean maternal 25(OH)D concentrations at 24-26 weeks of gestation were significantly lower in women who subsequently developed pre-eclampsia compared with those who did not (mean ± SD: 48.9 ± 16.8 versus 57.0 ± 19.1 nmol/l, P = 0.03). Women with 25(OH)D < 50 nmol/l at 24-26 weeks gestation experienced an increased risk of pre-eclampsia (adjusted odds ratio 3.24, 95% confidence interval 1.37-7.69), whereas the association was not statistically significant for maternal 25(OH)D level at 12-18 weeks of gestation.Conclusions Lower maternal 25(OH)D levels at late mid-trimester were associated with an increased risk of pre-eclampsia.

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Maternal serum 25(OH)D levels in the third trimester of pregnancy during the winter season

Abstract: This study showed a remarkable high rate of vitamin D deficiency in pregnant women during the winter season and we have found high levels of vitamin D in patients supplemented with multivitamins and in ones with good SES.

Cited by 23 publications

References 20 publications

Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

Vitamin D status in the first-trimester: effects of Vitamin D deficiency on pregnancy outcomes

Association Between Maternal Vitamin D Status and Risk of Gestational Diabetes Mellitus in Pregnant Women

Longitudinal vitamin D status in pregnancy and the risk of pre‐eclampsia

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