Maternal Sepsis, Chorioamnionitis, and Congenital Candida kefyr Infection in Premature Twins

Pineda, Carol; Kaushik, Atul; Kest, Helen; Wickes, Brian L.; Zauk, Adel

doi:10.1097/inf.0b013e31823eee1a

Cited by 19 publications

(15 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, Candida albicans was detected in 5.1% (3/59) of patients with preterm PROM, and two of these three patients had acute histologic chorioamnionitis, which are consistent with our prior reports [61,226]. Fungal infections are important because they are well recognized pathogens implicated in fetal death and serious neonatal complications [227][228][229][230][231][232][233][234][235][236][237], and they require specific antimicrobial agents not generally used in the context of preterm PROM.…”

Section: Author Manuscriptsupporting

confidence: 90%

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

Romero

Miranda

Chaemsaithong

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

354

294

View full text Add to dashboard Cite

Objective The objectives of this study were to: 1) determine the amniotic fluid (AF) microbiology of patients with preterm prelabor rupture of membranes (PROM); and 2) examine the relationship between intra-amniotic inflammation with and without microorganisms (sterile inflammation) and adverse pregnancy outcomes in patients with preterm PROM. Methods AF samples obtained from 59 women with preterm PROM were analyzed using cultivation techniques (for aerobic and anaerobic bacteria as well as genital mycoplasmas) and with broad-range polymerase chain reaction coupled with electrospray ionization mass spectrometry (PCR/ESI-MS). AF concentration of interleukin-6 (IL-6) was determined using ELISA. Results of both tests were correlated with AF IL-6 concentrations, and the occurrence of adverse obstetrical/perinatal outcomes. Results 1) PCR/ESI-MS, AF culture, and the combination of these two tests, each identified microorganisms in 36% (21/59), 24% (14/59) and 41% (24/59) of women with preterm PROM, respectively; 2) the most frequent microorganisms found in the amniotic cavity were Sneathia species and Ureaplasma urealyticum; 3) the frequency of microbial-associated and sterile intra-amniotic inflammation was overall similar [ 29% (17/59)]: - however, the prevalence of each differed according to the gestational age when PROM occurred ; 4) the earlier the gestational age at preterm PROM, the higher the frequency of both microbial-associated and sterile intra-amniotic inflammation; 5) the intensity of the intra-amniotic inflammatory response against microorganisms is stronger when preterm PROM occurs early in pregnancy; and 6) the frequency of acute placental inflammation (histologic chorioamnionitis and/or funisitis) was significantly higher in patients with microbial-associated intra-amniotic inflammation than in those without intra-amniotic inflammation [93.3% (14/15) vs. 38% (6/16); p=0.001]. Conclusions 1) The frequency of microorganisms in preterm PROM is 40% using both cultivation and PCR/ESI-MS; 2) PCR/ESI-MS identified microorganisms in the AF of 50% more women with preterm PROM than did AF culture; and 3) sterile intra-amniotic inflammation was present in 29% of these patients, and it was as or more common than microbial-associated intra-amniotic inflammation among those presenting after, but not before, 24 weeks of gestation.

show abstract

Section: Author Manuscriptsupporting

confidence: 90%

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

Romero

Miranda

Chaemsaithong

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

354

294

View full text Add to dashboard Cite

show abstract

“…Five twin pairs were collected through the MEDLINE search as far back as to 2000. 2 3 4 5 6 Plus this case report, there were six twin pairs in total. Their clinical data are summarized in Tables 1 and 2 .…”

Section: Review Of the Literaturementioning

confidence: 79%

Congenital Systemic Fungus Infection in Twin Prematurity—A Case Report and Literature Review

Chen

Tsai

et al. 2015

AJP Rep

View full text Add to dashboard Cite

Congenital candidemia sepsis is a serious condition especially for the prematurity. Early recognition is always not the scenario and this leads to high morbidity and mortality. Twin pregnancy complicates the problems further. This report presents a case of congenital candidiasis in a twin preterm and literatures review of five twin pairs with the same scenario. In conclusion, for twin prematurity, if one is suspected to have invasive candidiasis, both of them should receive a full course of antifungal therapy through the intravenous route.

show abstract

“…For example, a pregnant woman who frequently consumed organic dairy products developed a bloodstream infection with Candida kefyr that was transmitted through the placenta to her premature twin infants (Pineda et al , 2012). Whether any of the dairy products implicated in the report were unpasteurized was unknown.…”

Section: Resultsmentioning

confidence: 99%

“…Whether any of the dairy products implicated in the report were unpasteurized was unknown. C. kefyr is commonly found in raw fermented dairy products, and it is also able to grow in ultra-pasteurized cow’s milk (Gadaga et al , 2001; Pineda et al , 2012). Like C. kefyr , Candida catenulata is naturally present in some dairy products and is an extremely uncommon cause of human infection (Pineda et al , 2012).…”

Section: Resultsmentioning

confidence: 99%

“…C. kefyr is commonly found in raw fermented dairy products, and it is also able to grow in ultra-pasteurized cow’s milk (Gadaga et al , 2001; Pineda et al , 2012). Like C. kefyr , Candida catenulata is naturally present in some dairy products and is an extremely uncommon cause of human infection (Pineda et al , 2012). One case of C. catenulata fungemia in a patient with gastric cancer was believed to have resulted from frequent cheese consumption (Radosavljevic et al , 1999).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Invasive Fungal Infections Acquired from Contaminated Food or Nutritional Supplements: A Review of the Literature

Benedict

Chiller

Mody

2016

Foodborne Pathogens and Disease

View full text Add to dashboard Cite

Fungi are an integral part of the natural environment and, therefore, play many roles in relation to food: some fungi are used in food production, some are food sources themselves, and some are agents of food spoilage. Some fungi that contaminate food can also be harmful to human health. The harmful but noninfectious health consequences of mycotoxins have been well-characterized, but the extent to which fungi in food pose a risk for invasive infections is unknown. We conducted a literature review to identify cases of invasive fungal infections (IFIs) believed to have resulted from ingestion or inhalation of food, beverages, or dietary supplements (excluding Saccharomyces infections). We identified 11 publications describing cases or small outbreaks of IFIs related to foods or beverages and three describing IFIs related to dietary supplements. These food-associated IFIs were predominantly mold infections, and the few yeast infections were associated with dairy products. Suspected foodborne IFIs appear to be rare, but are increasingly described in the electronically searchable literature. They are associated with a variety of foods, are due to a variety of fungal pathogens, and primarily occur in persons with immunosuppressive conditions or other predisposing factors. Various guidelines for high-risk patients recommend avoidance of certain food products that may contain high levels of fungi, but further work is needed to evaluate the effectiveness of these restrictive diets in preventing fungal infections. The relationships between food spoilage, food insecurity, and IFI risk are another area that may warrant further exploration.

show abstract

Maternal Sepsis, Chorioamnionitis, and Congenital Candida kefyr Infection in Premature Twins

Cited by 19 publications

References 21 publications

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

Congenital Systemic Fungus Infection in Twin Prematurity—A Case Report and Literature Review

Invasive Fungal Infections Acquired from Contaminated Food or Nutritional Supplements: A Review of the Literature

Contact Info

Product

Resources

About