Maternal separation plus social isolation during adolescence reprogram brain dopamine and endocannabinoid systems and facilitate alcohol intake in rats

Amancio-Belmont, Octavio; Meléndez, Alline L. Becerril; Ruiz-Contreras, Alejandra E.; Méndez-Dı́az, Mónica; Prospéro-Garcı́a, Oscar

doi:10.1016/j.brainresbull.2020.08.002

Cited by 22 publications

(16 citation statements)

References 56 publications

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“…In contrast, other studies in males found Drd1 expression in the NAc to be unaffected by ELS ( 108 , 170 ). Maternal separation increased NAc Drd2 in males ( 119 , 144 , 171 ), an effect which was accompanied by a stress-induced increase in dendritic morphology in the NAc ( 171 ). Together these studies suggest sex-specific impacts of ELS on dopamine receptors in NAc, although additional research is needed to confirm sex-specific effects directly and determine the contributions of type and timing of ELS.…”

Section: Impact Of Early Life Stress On Transcription and Epigenetic Regulation Within Nacmentioning

confidence: 97%

“…Blocking BDNF/TrkB signaling in NAc during exposure to ELS in mice (maternal separation from P3-14) simultaneously restored sucrose preference and sensitized behavioral response to chronic unpredictable adult stress on the open field test ( 165 ), indicating that the enduring and opposite consequences of ELS on motivated and anxiety-related behavior are regulated by transient developmental alterations in BDNF-TrkB signaling. ELS also increased expression of cannabinoid 1 receptors ( Cb1r ) and FK506-binding protein ( Fkbp5 ) in NAc, which was further linked to alcohol consumption in rodents ( 119 , 166 ). ELS in the form of predator odor exposure from P1-3 decreased expression of mu and kappa opioid receptors ( Orpm1 and Oprk1 , respectively) in female but not male NAc acutely on P3, although Orpm1 expression rebounded and was significantly higher than control females by postnatal day 33 ( 167 ).…”

Section: Impact Of Early Life Stress On Transcription and Epigenetic Regulation Within Nacmentioning

confidence: 97%

“…Maternal separation rearing increases both lever pressing and consumption of ethanol in male Swiss ICR mice ( 116 ) and male and female Sprague-Dawley rats ( 117 , 118 ). Additionally, maternal separation increases ethanol consumption in free-choice tasks in both male C57BL/6 mice ( 105 ) and male Wistar rats ( 119 ). Similarly, increases in ethanol consumption have been reported in maternal deprivation reared male and female Sprague-Dawley rats ( 120 ).…”

Section: Impact Of Early Life Stress On Motivated Behavior and Reward Circuit Activity From Non-human Animal Modelsmentioning

confidence: 99%

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Impact of Early Life Stress on Reward Circuit Function and Regulation

et al. 2021

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Early life stress – including experience of child maltreatment, neglect, separation from or loss of a parent, and other forms of adversity – increases lifetime risk of mood, anxiety, and substance use disorders. A major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Here, we review evidence of the impact of early life stress on reward circuit structure and function from human and animal models, with a focus on the NAc. We then connect these results to emerging theoretical models about the indirect and direct impacts of early life stress on reward circuit development. Through this review and synthesis, we aim to highlight open research questions and suggest avenues of future study in service of basic science, as well as applied insights. Understanding how early life stress alters reward circuit development, function, and motivated behaviors is a critical first step toward developing the ability to predict, prevent, and treat stress-related psychopathology spanning mood, anxiety, and substance use disorders.

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Section: Impact Of Early Life Stress On Transcription and Epigenetic Regulation Within Nacmentioning

confidence: 97%

Section: Impact Of Early Life Stress On Transcription and Epigenetic Regulation Within Nacmentioning

confidence: 97%

Section: Impact Of Early Life Stress On Motivated Behavior and Reward Circuit Activity From Non-human Animal Modelsmentioning

confidence: 99%

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Impact of Early Life Stress on Reward Circuit Function and Regulation

et al. 2021

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“…Social isolation also produces anxiety-type behaviors in rodents, which are demonstrated by their performance in tests such as the Open Field and Elevated-Plus-Maze (EPM; Botelho et al, 2007;Pritchard et al, 2013;Kumari et al, 2016;Shetty and Sadananda, 2017;Sequeira-Cordero et al, 2019). The EPM is one of the most widely used models for the evaluation of anxiety-related behavior (Botelho et al, 2007;Amancio-Belmont et al, 2020). It is based upon the natural preference of these animals for dark and protected places, and their anxiety is thus measured by the proportion of test time that they remain in the closed arms of the maze, without coming into contact with the open areas (Pellow et al, 1985;Botelho et al, 2007;Casarrubea et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…It is based upon the natural preference of these animals for dark and protected places, and their anxiety is thus measured by the proportion of test time that they remain in the closed arms of the maze, without coming into contact with the open areas (Pellow et al, 1985;Botelho et al, 2007;Casarrubea et al, 2016). Research indicates that exposure to social isolation in adolescence results in an increased level of locomotor activity, as well as a reduced number of entries into-and time spent in-the open arms of the maze (Kumari et al, 2016;Shetty and Sadananda, 2017;Amancio-Belmont et al, 2020); a pattern which has shown itself to be reversible through the use of various types of anxiolytic drugs such as Diazepam, Alprazolam y Pentylenetetrazol (Pellow et al, 1985;Sorregotti et al, 2013;Sprowles et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

Acero-Castillo

Ardila-Figueroa

Oliveira

2021

Front. Behav. Neurosci.

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Chronic Social Isolation (CSI) is a model of prolonged stress employed in a variety of studies to induce depression and anxious behavior in rats. The present study aims to evaluate the effect of CSI on male Wistar rats in terms of “anhedonic-type” behavior in the Sucrose Preference Test (SPT) and anxiogenic profile in the elevated-plus-maze (EPM) test, as well as evaluating the effect of resocialization upon sucrose consumption. A total of 24 adolescent male Wistar rats were evaluated. The animals were housed either together (communally) or socially isolated for 21 days, and then exposed for four consecutive days to the SPT test [water vs. a 32% sucrose solution (SS)]. Four days later, they were again subjected to the SPT test (32% vs. 0.7% SS), and then tested on the EPM apparatus 3 days later. Following the completion of the anxiogenic profile of the model, the animals were resocialized for 72 h and then re-tested once again using the SPT (32% vs. 0.7% SS). Twenty-four hours after this final consumption, the animals were euthanized to record the weight of their adrenal glands (AG). It was found that exposure to CSI produces anhedonic-type behavior and an anxiogenic profile in adolescent male rats, as evidenced in both the SPT and EPM tests, as well as in the animals’ physiological stress response. It was also demonstrated that resocialization does not reverse the anhedonic-type behavior, nor the physiological response to stress.

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Anxiety, aggression, reward sensitivity, and forebrain dopamine receptor expression in a laboratory rat model of early‐life disadvantage

Lonstein,

Vitale,

Olekanma

et al. 2023

Developmental Psychobiology

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Despite early‐life disadvantage (ELD) in humans being a highly heterogenous construct, it consistently predicts negative neurobehavioral outcomes. The numerous environmental contributors and neural mechanisms underlying ELD remain unclear, though. We used a laboratory rat model to evaluate the effects of limited resources and/or heavy metal exposure on mothers and their adult male and female offspring. Dams and litters were chronically exposed to restricted (1‐cm deep) or ample (4‐cm deep) home cage bedding postpartum, with or without lead acetate (0.1%) in their drinking water from insemination through 1‐week postweaning. Restricted‐bedding mothers showed more pup‐directed behaviors and behavioral fragmentation, while lead‐exposed mothers showed more nestbuilding. Restricted bedding‐raised male offspring showed higher anxiety and aggression. Either restricted bedding or lead exposure impaired goal‐directed performance in a reinforcer devaluation task in females, whereas restricted bedding alone disrupted it in males. Lead exposure, but not limited bedding, also reduced sucrose reward sensitivity in a progressive ratio task in females. D1 and D2 receptor mRNA in the medial prefrontal cortex and nucleus accumbens (NAc) were each affected by the early‐life treatments and differently between the sexes. Most notably, adult males (but not females) exposed to both early‐life treatments had greatly increased D1 receptor mRNA in the NAc core. These results illuminate neural mechanisms through which ELD threatens neurobehavioral development and highlight forebrain dopamine as a factor.

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Maternal separation plus social isolation during adolescence reprogram brain dopamine and endocannabinoid systems and facilitate alcohol intake in rats

Cited by 22 publications

References 56 publications

Impact of Early Life Stress on Reward Circuit Function and Regulation

Impact of Early Life Stress on Reward Circuit Function and Regulation

Anhedonic Type Behavior and Anxiety Profile of Wistar-UIS Rats Subjected to Chronic Social Isolation

Anxiety, aggression, reward sensitivity, and forebrain dopamine receptor expression in a laboratory rat model of early‐life disadvantage

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