Maternal <scp>IGF</scp>1 and <scp>IGF</scp>1R polymorphisms and the risk of spontaneous preterm birth

He, Jianxing; Lai, Yuxiong; Liu, Huihui; Liu, Guangjian; li, Wei-Dong; Fan, Xuejiao; Wei, Xu-Hong; Xia, Xiaoyan; Kuang, Yashu; Liu, Xiaodan; Chen, Niannian; Lu, Jinhua; Chen, Qiaozhu; W, Mai; Xia, Huimin; Qiu, Xiu

doi:10.1002/jcla.22125

Cited by 14 publications

(19 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[27] Among Chinese pregnant women, those carrying GA/AA genotypes were more likely to have spontaneous preterm infants. [28] However, the effects of these three polymorphisms on individual susceptibility to ONFH had been rarely reported in Chinese Han population.…”

Section: Discussionmentioning

confidence: 99%

“…These results were in line with the relevant studies carried out in other types of human disease. [26–28] In addition, strong linkage disequilibrium was observed between polymorphisms rs5742714 and rs972936. Haplotype analysis demonstrated that the haplotype C-T dramatically elevated the susceptibility to ONFH when compared to C-C, while G-T decreased the individual susceptibility to ONFH among Chinese Han population.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

2019

View full text Add to dashboard Cite

The study was performed to investigate the genetic associations of IGF-1 polymorphisms rs35767, rs5742714, and rs972936 with susceptibility to osteonecrosis of the femoral head (ONFH) among Chinese Han population. Totally, 101 ONFH patients and 128 healthy controls were enrolled. Hardy–Weinberg equilibrium (HWE) was detected with chi-square test in control group. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated to estimate the relationship between IGF-1 polymorphisms and ONFH risk. Besides, hyplotype analysis was performed to examine linkage disequilibrium between the studied polymorphisms. Genotype AA and allele A of polymorphism rs35767 were more frequent in control group, and offered protection for ONFH onset (AA: OR = 0.382, 95% CI = 0.158-0.923; A: OR = 0.650, 95% CI = 0.442–0.956). Furthermore, the negative relationship was also observed between ONFH risk and polymorphism rs5742714 under the comparisons CG vs CC, and G vs C (OR = 0.395, 95%CI = 0.199–0.787; OR = 0.346, 95%CI = 0.191–0.627). While the polymorphism rs972936 significantly enhanced the disease risk (CT vs CC: OR = 2.434, 95% CI = 1.184–5.003; TT vs CC: OR = 2.497, 95% CI = 1.040–5.990). Furthermore, haplotype analysis demonstrated that C-T (rs5742714–rs972936) could increase ONFH risk (OR = 2.177, 95% CI = 1.444–3.283), while G-T might be a protective factor for ONFH (OR = 0.472, 95% CI = 0.254–0.878). IGF-1 polymorphisms rs35767, rs5742714, and rs972936 show significant association with ONFH risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

2019

View full text Add to dashboard Cite

show abstract

“…Although the investigators concluded that ligands of IGF1R that regulate IGF1R dependent signaling cascades are associated with sPTB 16 , how dysregulation of IGF1R signaling itself can be involved in sPTB was not addressed. A candidate gene-based association study on the Chinese population identified an SNP in IGF1R (rs2229765) which is associated with reduced risk of sPTB in women with GA or AA genotype as compared to the women with GG genotype 17 . A study in mouse and human breast tumor epithelial cell lines reported that downregulation of IGF1R expression increases cellular stress and cytokine (IL-6 and CCL2) production 18 .…”

Section: Genomic Approaches To Study Sptbmentioning

confidence: 99%

Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes

Bhattacharjee

Maitra

2021

npj Genom. Med.

View full text Add to dashboard Cite

Preterm birth (PTB) is a major cause of neonatal mortality and health complications in infants. Elucidation of its genetic underpinnings can lead to improved understanding of the biological mechanisms and boost the development of methods to predict PTB. Although recent genome-based studies of both mother and fetus have identified several genetic loci which might be implicated in PTB, these results suffer from a lack of consistency across multiple studies and populations. Moreover, results of functional validation of most of these findings are unavailable. Since medically indicated preterm deliveries have well-known heterogeneous causes, we have reviewed only those studies which investigated spontaneous preterm birth (sPTB) and have attempted to suggest probable biological mechanisms by which the implicated genetic factors might result in sPTB. We expect our review to provide a panoramic view of the genetics of sPTB.

show abstract

“…According to statistics, perinatal mortality is as high as 70% in low birth weight (LBW) with neonatal weight below 2,500 g ( Hack et al, 1994 ; Rutter, 1995 ), most of them are born preterm. Growing evidence has shown that the incidence and development of PTB is a complex process that is influenced by a variety of environmental and genetic factors ( He et al, 2017 ; Liu et al, 2017 ; Qiu et al, 2017 ; Xiao et al, 2016 ). Therefore, it is helpful to develop approaches of effective prevention and treatment of neonatal morbidity and mortality by elucidating etiological factors contributing to PTB or LBW.…”

Section: Introductionmentioning

confidence: 99%

Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers

Chen

Lin

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background Studies have reported an increased risk of adverse pregnancy outcome associated with pre-pregnancy body mass index (BMI). However, the data on such associations in urban areas of southern Chinese women is limited, which drive us to clarify the associations of pre-pregnancy BMI and the risks of adverse pregnancy outcomes (preterm birth (PTB) and low birth weight (LBW)) and maternal health outcomes (gestational hypertension and cesarean delivery). Methods We performed a hospital-based case-control study including 3,864 Southern Chinese women who gave first birth to a live singleton infant from January 2015 to December 2015. PTB was stratified into three subgroups according to gestational age (extremely PTB, very PTB and moderate PTB). Besides, we combined birth weight and gestational age to dichotomise as being small for gestational age (SGA, less than the tenth percentile of weight for gestation) and non-small for gestational age (NSGA, large than the tenth percentile of weight for gestation), gestational week was also classified into categories of term, 34-36 week and below 34 week.. We then divided newborns into six groups: (1) term and NSGA; (2) 34–36 week gestation and NSGA; (3) below 34 week gestation and NSGA; (4) term and SAG; (5) 34–36 week gestation and SAG; (6) below 34 week gestation and SAG. Adjusted logistic regression models was used to estimate the odds ratios of adverse outcomes. Results Underweight women were more likely to give LBW (AOR = 1.44, 95% CI [1.11–1.89]), the similar result was seen in term and SAG as compared with term and NSAG (AOR = 1.78, 95% CI [1.45–2.17]), whereas underweight was significantly associated with a lower risk of gestational hypertension (AOR = 0.45, 95% CI [0.25–0.82) and caesarean delivery (AOR = 0.74, 95% CI [0.62–0.90]). The risk of extremely PTB is relatively higher among overweight and obese mothers in a subgroup analysis of PTB (AOR = 8.12, 95% CI [1.11–59.44]; AOR = 15.06, 95% CI [1.32–172.13], respectively). Both maternal overweight and obesity were associated with a greater risk of gestational hypertension (AOR = 1.71, 95% CI [1.06–2.77]; AOR = 5.54, 95% CI [3.02–10.17], respectively) and caesarean delivery (AOR = 1.91, 95% CI [1.53–2.38]; AOR = 1.85, 95% CI [1.21–2.82], respectively). Conclusions Our study suggested that maternal overweight and obesity were associated with a significantly higher risk of gestational hypertension, caesarean delivery and extremely PTB. Underweight was correlated with an increased risk of LBW and conferred a protective effect regarding the risk for gestational hypertension and caesarean delivery for the first-time mothers among Southern Chinese.

show abstract

Maternal IGF1 and IGF1R polymorphisms and the risk of spontaneous preterm birth

Abstract: Our findings suggest that polymorphisms of IGF1 rs972936 and IGF1R rs2229765 were associated with the risk of SPTB in Chinese pregnant women and these effects depend on the maternal metabolic status.

Cited by 14 publications

References 33 publications

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

IGF-1 polymorphisms modulate the susceptibility to osteonecrosis of the femoral head among Chinese Han population

Spontaneous preterm birth: the underpinnings in the maternal and fetal genomes

Association of pre-pregnancy body mass index with adverse pregnancy outcome among first-time mothers

Contact Info

Product

Resources

About