Maternal Risk Factors for Term Neonatal Seizures: Population-Based Study in Colorado, 1989—2003

Hall, Deborah A.; Wadwa, R. Paul; Goldenberg, Neil A.; Norris, Jill M.

doi:10.1177/08830738060210092001

Cited by 32 publications

(38 citation statements)

References 19 publications

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“…Our cohort is similar to other reports in the following: increased risk of neonatal seizures among males (13, 14); increased risk of mortality in preterm infants (9, 15); increased risk of seizures among infants born post-term(16); and increased risk of seizures among neonates with perinatal asphyxia (1-3, 16-18). …”

Section: Discussionsupporting

confidence: 89%

Predictors of Mortality in Neonates with Seizures; a Prospective Cohort Study

Heljic

Uzicanin

Čatibušić

et al. 2016

Med Arh

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Objective:The aim of this study was to analyze prognostic indicators for mortality in neonates with seizures in a level III Neonatal Intensive Care Unit (NICU).Patients and methods:A cohort of 100 neonates with clinically manifested seizures hospitalized in the NICU during 4 years period was prospectively monitored for the first year of life. The cohort consisted of 33 preterm and 67 full-term babies with 60 male and 40 female infants.Results:The mortality rate in the first year of life of infants with seizures in the neonatal period was 23%. The most common cause of seizures was birth asphyxia for full-term infants and intra-periventricular hemorrhage for preterm infants. Death was more common in pre-term than term infants (p <0,005). Simple regression demonstrated statistically significant associations between death in the first year of life and a cluster of highly associated variables: resuscitation (p<0, 01), mechanical ventilation (p<0,01) and asphyxia (p<0,05). This cluster of variables significantly correlates with: gestational age (p<0, 05), birth weight (p<0, 05) and intracranial hemorrhage (p<0, 05).Conclusion:In this cohort of neonates with seizures asphyxia requiring neonatal resuscitation was the primary risk factor for death.

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Section: Discussionsupporting

confidence: 89%

Predictors of Mortality in Neonates with Seizures; a Prospective Cohort Study

Heljic

Uzicanin

Čatibušić

et al. 2016

Med Arh

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“…A previous study suggested an association between pre-existing diabetes mellitus and neonatal seizures (11), but not with gestational diabetes. Others have suggested infant macrosomia and advanced maternal age as reasons for increased adverse outcome in infants of diabetic mothers (18).…”

Section: Discussionmentioning

confidence: 90%

“…The reported effect of maternal age on the risk of newborn seizures has been inconsistent (10, 11, 15). The increased risk of seizures during birth hospitalization among women ≥ 40 in our cohort was small but significant when compared with women aged 25-29.…”

Section: Discussionmentioning

confidence: 99%

“…Past studies evaluating risk factors for seizures in term newborns were limited by small size of the affected cohort (3, 5, 6), focus on a single (9) or only a restricted number of maternal risk factors (3, 5) or use of only those variables available on birth and death certificate data (5, 10, 11). We evaluated antenatal and intrapartum risk factors for seizures during the birth hospitalization in newborns ≥36 weeks gestational age in a large population using birth certificate data linked to California statewide maternal and infant hospital discharge diagnoses from 1998-2002.…”

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confidence: 99%

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Antenatal and Intrapartum Risk Factors for Seizures in Term Newborns: A Population-Based Study, California 1998-2002

Glass

Pham

Danielsen³

et al. 2009

The Journal of Pediatrics

151

113

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Objective-To assess antenatal and intrapartum risk factors for seizures occurring during the birth admission.Study design-Using multivariable logistic regression analysis, we evaluated the association between maternal characteristics and birth admission seizures in a cohort of 2.3 million California children born ≥36 weeks gestation from 1998-2002 using the California Office of Statewide Planning and Development database containing birth certificates linked to infant and maternal hospital discharge abstracts.Results-The incidence of seizures during the birth admission was 0.95/1000 live births. In an adjusted analysis, infants of women who were 40 or older, were nulliparous, had diabetes mellitus, intrapartum fever or infection or who delivered ≥42 weeks had an increased risk of seizures. Infants of Hispanic and Asian mothers had a lower risk when compared with infants of white mothers.Conclusions-Several maternal antenatal and intrapartum factors increased the risk of seizures during the birth admission. Identifying and avoiding risks for neonatal seizures may lead to lower infant neurological morbidity and mortality. Keywords Population attributable riskThe estimated incidence of seizures in term newborns is 1-3.5 per 1000 live births (1-4) (5,6). Seizures in the neonate frequently reflect significant underlying brain injury such as hypoxic ischemic injury, stroke, intracranial infection or hypoglycemia (2,7). Neonates with seizures have a high incidence of mortality and adverse long-term neurological outcome (5,8).Address correspondence to: Hannah C. Glass, University of California San Francisco, Department of Neurology Box 0663, 521 Parnassus Avenue, San Francisco,, Email: Hannah.Glass@ucsf.edu. Edited by AJ and WFB The NINDS Neurological Sciences Academic Development Award (NS01692) supports HCG.The authors declare no conflicts of interest.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access MethodsWe examined a population-based cohort using a (642.41-642.42, 642.51-642.52, 642.61-642.62). Mode of delivery was categorized into four groups: routine vaginal, operative vaginal (using vacuum or forceps), daytime cesarean (during the hours 6:00-17:00) and nighttime cesarean (17:01-5:59). Potential infant confounding variables included meningitis (320-320.9, 322.9) and other infection, not meningitis (771.4,771.8-89).Our outcome of interest was defined as convulsions (780.3) or seizures in a newborn (779.0) diagnosed during the birth hospitalization. StatisticsContinuous variables were compared using a two-tailed Student's t-test. The association be...

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“…Neonatal seizures are a common neurologic diagnosis in the Neonatal Intensive Care Unit (NICU), occurring in 1.8-3.5/1000 live births or 14,000 newborns annually in the US (Hall et al, 2006; Glass et al, 2009a). They contribute to injury after hypoxia-ischemia (Legido, et al, 1991; Wirrell et al, 2001; Miller et al, 2002; Glass et al, 2009b) and are frequently associated with long-term deleterious consequences including intellectual disability, cerebral palsy, epilepsy, and other neurodevelopmental disabilities (Clancy et al, 1991; McBride et al, 2000; Toet et al, 2005; Pisani et al, 2007; Nagarajan et al, 2010; Glass et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Dry Sensors for Neonatal EEG Recordings

Fridman

Cordeiro

Rais-Bahrami

et al. 2016

Journal of Clinical Neurophysiology

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Introduction Neonatal seizures are a common neurologic diagnosis in Neonatal Intensive Care Units (NICUs), occurring in approximately 14,000 newborns annually in the US. While the only reliable means of detecting and treating neonatal seizures is with an EEG recording, many neonates do not get an EEG or experience delays in getting them. Barriers to obtaining neonatal EEGs include: 1) lack of skilled EEG technologists to apply conventional wet electrodes to delicate neonatal skin, 2) poor signal quality due to improper skin preparation and artifact, 3) extensive time needed to apply electrodes. Dry sensors have the potential to overcome these obstacles but have not been previously evaluated on neonates. Methods Sequential and simultaneous recordings with wet and dry sensors were performed for one hour on 27 neonates from 35-42.5 weeks postmenstrual age. Recordings were analyzed for correlation and amplitude, and were reviewed by neurophysiologists. Performance of dry sensors on simulated vernix was examined. Results Analysis of dry and wet signals showed good time-domain correlation (reaching >0.8) given the non-superimposed sensor positions, and similar power spectral density curves. Neurophysiologist reviews showed no statistically significant difference between dry and wet data on most clinically-relevant EEG background and seizure patterns. There was no skin injury after 1 hr of dry sensor recordings. In contrast to wet electrodes, impedance and electrical artifact of dry sensors were largely unaffected by simulated vernix. Conclusions Dry sensors evaluated in this study have the potential to provide high-quality, timely EEG recordings on neonates with less risk of skin injury.

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Maternal Risk Factors for Term Neonatal Seizures: Population-Based Study in Colorado, 1989—2003

Cited by 32 publications

References 19 publications

Predictors of Mortality in Neonates with Seizures; a Prospective Cohort Study

Predictors of Mortality in Neonates with Seizures; a Prospective Cohort Study

Antenatal and Intrapartum Risk Factors for Seizures in Term Newborns: A Population-Based Study, California 1998-2002

Evaluation of Dry Sensors for Neonatal EEG Recordings

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