Maternal responses to infant vocalizations and olfactory cues in rats and mice

Smotherman, William P.; Bell, Robert A.; Starzec, James J.; Elias, Jeffrey W.; Zachman, Thomas A.

doi:10.1016/s0091-6773(74)91026-8

Cited by 293 publications

(200 citation statements)

References 16 publications

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“…Moreover, maternal behavior was also impaired in the mice after removal of the olfactory bulb [18]. Whereas, postpartum female mice showed retrieving behavior after chemosensory cues from pups without the use of audiovisual cues [19] [20].…”

Section: Discussionmentioning

confidence: 98%

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

Horibe¹,

Yoshino²,

Domoto³

et al. 2017

JBBS

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In the present study, we investigated whether blue light emission diode (LED) light exposure affects the maternal behavior of mice. The brain function of the offspring mice, including short-term memory, locomotor activity, anxiety-like behavior, and depression-like behavior, was evaluated. Pregnant mice at day 11 were housed in the apparatus for exposure to blue LED light during the daytime. Nesting behavior and the survival of pups were observed until weaning. After weaning, the offspring mice were bred in normal light conditions until 12 weeks old, and then the Y-maze test, open field test, and tail suspension test were performed. Retinal functions were evaluated by electroretinogram and histological analysis. Blue LED light exposure during the daytime induced retinal damage, but did not affect behavior related to maternal care in maternal mice. In the offspring mice, blue LED light exposure during the daytime did not affect the retina or brain functions. These findings suggest that blue LED light during the daytime might not be a risk factor for disruption of the mother-infant relationship or offspring brain development in mice.

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Section: Discussionmentioning

confidence: 98%

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

Horibe¹,

Yoshino²,

Domoto³

et al. 2017

JBBS

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“…As alluded to above, rodent young are not passive recipients of maternal care, but provide cues that elicit mother-pup interactions (Moltz and Leon, 1973;Reisbick et al, 1975;Smotherman et al, 1974). In fact, the rodent dam is sensitive to the changing stimulus qualities of the pups (Meier and Schutzman, 1968;Young, 1965) and shows systematic changes in maternal behavior depending on the nature of the treatment that the offspring have received (Barnett and Burn, 1967;Bell et al, 1974) and the time during lactation in which the manipulations occur (Smotherman et al, 1977a, b).…”

Section: Discussionmentioning

confidence: 99%

Manipulations During the Second, but not the First, Week of Life Increase Susceptibility to Cocaine Self-Administration in Female Rats

Flagel

Vázquez

Robinson

2003

Neuropsychopharmacol

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We compared the effects of manipulations during week 1 vs week 2 of life on the propensity to self-administer cocaine. Pups received daily subcutaneous saline injections, were handled briefly, or remained undisturbed during their respective treatment periods. Animals handled during the second week of life exhibited increased locomotor response to novelty when tested on postnatal day (PND) 48, compared to all other groups. Rats were implanted with jugular catheters on PND 70 and then given the opportunity to self-administer (0.125 mg/kg/infusion) cocaine for 5 consecutive days (1 h sessions). The dose was then raised to 0.25 mg/kg/infusion for 5 days and to 0.5 mg/kg/infusion for the final 5 days of testing. Only animals manipulated during the second week of life acquired drug-taking behavior. These effects were both stimulus-and gender-specific. Females handled during the second week of life acquired cocaine selfadministration (SA) at the lowest dose, and females injected during the second week of life acquired at the intermediate dose. Males injected during the second week of life showed a similar, but more variable, drug-taking pattern. There were no group differences in serum corticosterone response to novelty, although relative to undisturbed animals and those manipulated in the first week of life, female animals manipulated during the second week of life had lower basal expression of hippocampal glucocorticoid receptor mRNA in adulthood. We conclude that the second week of life in the rodent is a sensitive period during which manipulations result in a more vulnerable phenotype for the acquisition of cocaine SA.

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Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

“…The first period in Figure 1 (minutes 0-3) illustrates this response. It is known that isolation-induced USV has communicatory value for an isolated pup, both hastening and directing maternal retrieving behavior [18,98].Reunion period-In the presence of the dam in the second period, the rate of USV is significantly reduced from the calling rate in the initial isolation (minutes 3-6 in Figure 1). This decrease in vocalizations has been called 'companion comfort' or, more neutrally, 'contact quieting'.…”

mentioning

confidence: 98%

Acquisition and expression of a socially mediated separation response

Shair¹

2007

Behavioural Brain Research

108

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INTRODUCTIONSocial bonds are made up of numerous subsystems mediating the overall social relationships that develop between infants and caretakers. The effects of an infant's formation of early life relationships and its social interactions with caretakers are known to last well in to adulthood with both beneficial and harmful effects [28,35,70]. In our laboratory, we study the development of social relationships between infant rats and their dams, sires, and littermates using an isolation, reunion, and re-isolation test paradigm.Infant rats emit ultrasonic vocalizations (USV) in a variety of situations, including as a response to isolation, physical manipulation, and thermal and olfactory challenge [1][2][3]6,19,25,46,79,80,82,97]. Many researchers have used the presence and absence of these sounds to make inferences about the internal state of the rodents, e.g., isolation-induced USV's have often been called "distress vocalizations" [29,76,78].The isolation-induced vocalization of a rat pup is modulated both by current social interactions and by the pup's rearing experience. This modulation of USV by social interactions provides a paradigm for investigating the neurobehavioral mechanisms underlying acquisition and expression of infant attachment. What is maternal potentiation of isolation-induced vocalizations of infant rats?Maternal potentiation of ultrasonic vocalization occurs when, after a brief contact with the dam, isolated infant rats produce USV at a rate significantly higher than they would during an isolation not preceded by dam contact. Although the definition may seem of narrow interest, there is a growing belief that the potentiation phenomenon has broad applicability for the study of early life social relationships in many species. But before going further, the reader needs to understand the usual test paradigm in our laboratory.Developmental Psychobiology, Unit 40, New York State Psychiatric Institute, 1051 Riverside Dr. NY, NY 100032, Tele 212-543-5695, Fax 212-543-5467, hns1@columbia.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptTest procedure-On the day of testing, the dam is removed from the home cage and anesthetized. The litter is allowed to adapt to her removal for ~15-20min in the home cage on a thermoregulated heating pad. Then, each pup is tested in turn. The pup is picked up and placed alone in a clean polycarbonate rectangular box (18 × 21 × 20 cm) at room temperature. The test consists of three periods, which can range from 1-5min in length (3mi...

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Maternal responses to infant vocalizations and olfactory cues in rats and mice

Cited by 293 publications

References 16 publications

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

Manipulations During the Second, but not the First, Week of Life Increase Susceptibility to Cocaine Self-Administration in Female Rats

Acquisition and expression of a socially mediated separation response

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