Maternal residence near municipal waste incinerators and the risk of urinary tract birth defects

Cordier, Sylvaine; Lehébel, Anne; Amar, Emmanuelle; Anzivino-Viricel, Lucie; Hours, Martine; Monfort, Christine; Chevrier, Cécile; Chiron, Mireille; Robert-Gnansia, Élisabeth

doi:10.1136/oem.2009.052456

Cited by 43 publications

(31 citation statements)

References 22 publications

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“…We located 14 studies that examined effects of combined exposure to multiple metals (Table 1). We summarize results by health outcome: birth defects (29), reproductive outcomes (30), cognitive and motor development (31-39), and behavior (34, 40-42). …”

Section: Epidemiologic Studiesmentioning

confidence: 99%

“…One case-control study examined the association between risk of urinary tract birth defects and heavy metals as a component of a mixture emitted by municipal solid waste incinerators (MSWIs)(29). Exposure to MSWI emissions at maternal residence early in pregnancy was modeled based on data collected from regional MSWIs on constituents including three groups of metals: 1) Pb, Mn, copper, and chromium; 2) nickel and As; and 3) cadmium (Cd) and mercury (Hg).…”

Section: Birth Defectsmentioning

confidence: 99%

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Chemical mixtures and children's health

Henn

Coull²,

Wright³

2014

Current Opinion in Pediatrics

129

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Purpose of Review Humans are routinely exposed to multiple chemicals simultaneously or sequentially. There is evidence that the toxicity of individual chemicals may depend on the presence of other chemicals. Studies on chemical mixtures are limited, however, due to lack of sufficient exposure data, limited statistical power, and difficulty in the interpretation of multi-dimensional interactions. This review summarizes the recent literature examining chemical mixtures and pediatric health outcomes, with an emphasis on metal mixtures. Recent Findings Several studies report significant interactions between metals in relation to pediatric health outcomes. Two prospective studies found interactive effects of early life lead and manganese exposures on cognition. In two different cohorts, interactions between lead and cadmium exposures were reported on reproductive hormone levels and on neurodevelopment. Effects of lead exposure on impulsive behavior and cognition were modified by mercury exposure in studies from Canada and Denmark. However, there is little consistency related to exposure indicators and statistical approaches for evaluating interaction. Summary Several studies suggest that metals interact to cause health effects that are different from exposure to each metal alone. Despite the nearly infinite number of possible chemical combinations, mixtures research represents real life exposure scenarios and warrants more attention, particularly in the context of uniquely vulnerable children.

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Section: Epidemiologic Studiesmentioning

confidence: 99%

Section: Birth Defectsmentioning

confidence: 99%

Chemical mixtures and children's health

Henn

Coull²,

Wright³

2014

Current Opinion in Pediatrics

129

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“…Porta et al 12 report an increased risk in cancer of 3.5% for people living close to old incinerators but note that studies suffer from limitations due to poor exposure assessment, ecological level of analysis and lack of information on relevant confounders. Most of these, and other studies, [13][14][15][16][17] are concerned with older incinerators, and their results may not be applicable to incinerators currently in operation and under tighter regulatory control.…”

Section: Strengths and Limitations Of This Studymentioning

confidence: 99%

Spatial analysis of health effects of large industrial incinerators in England, 1998–2008: a study using matched case–control areas

et al. 2013

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ObjectivesTo assess whether residential proximity to industrial incinerators in England is associated with increased risk of cancer incidence and mortality.DesignRetrospective study using matched case–control areas.SettingFive circular regions of radius 10 km near industrial incinerators in England (case regions) and five matched control regions, 1998–2008.ParticipantsAll cases of diseases of interest within the circular areas.Primary and secondary outcome measuresCounts of childhood cancer incidence (<15 years); childhood leukaemia incidence (<15 years); leukaemia incidence; liver cancer incidence; lung cancer incidence; non-Hodgkin's lymphoma incidence; all-cause mortality; infant mortality (<1 year) and liver cancer mortality.ResultsThe estimated relative risks for case circles versus control circles for the nine outcomes considered range from 0.94 to 1.14, and show neither elevated risk in case circles compared to control areas nor elevated risk with proximity to incinerators within case circles.ConclusionsThis study applies statistical methods for analysing spatially referenced health outcome data in regions with a hypothesised exposure relative to matched regions with no such exposure. There is no evidence of elevated risk of cancer incidence or mortality in the vicinity of large industrial incinerators in England.

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“…In particular, the development of the nervous system of the fetus is affected irreversibly by methylmercury through the exposure of women during pregnancy (13, 31). The transfer of metals from the mother to the fetus is possible through the placenta, and carryover from breast milk can produce some symptoms in early childhood such as neuropsychological disorders and urinary tract defects (1, 11,12,17,40,42). Problems more frequently associated with heavy metal exposure from food include long-term effects in several tissues, in particular mutagenicity (25, 39), carcinogenicity (3 , 8), teratogenicity (43), immunotoxicity (36), and endocrine disruption (34).…”

mentioning

confidence: 99%

Heavy Metals in Canned Tuna from Italian Markets

Russo¹,

Voi

Simone³

et al. 2013

Journal of Food Protection

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Fish is a good source of nutrients for humans but can pose a risk to human health because of the possible presence of some xenobiotics such as heavy metals and persistent organic contaminants. Constant monitoring is needed to minimize health risks and ensure product quality and consumer safety. The aim of the present study was to use atomic absorption spectrometry to determine the concentrations of some heavy metals (Hg, Pb, and Cd) in tuna packaged in different kinds of packages (cans or glass) in various countries (Italy and elsewhere). Concentrations of Cd and Hg were within the limits set by European Commission Regulation (EC) No 1881/2006 and in many samples were below the detection limit. Pb concentrations exceeded European limits in 9.8% of the analyzed samples. These results are reassuring in terms of food safety but highlighted the need to constantly monitor the concentrations of heavy metals in fish products that could endanger consumer health.

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Maternal residence near municipal waste incinerators and the risk of urinary tract birth defects

Abstract: This study confirms our previous observation of a link between the risk of urinary tract birth defects and exposure to MSWI emissions in early pregnancy and illustrates the effect of participation bias on risk estimates of environmental health impacts.

Cited by 43 publications

References 22 publications

Chemical mixtures and children's health

Chemical mixtures and children's health

Spatial analysis of health effects of large industrial incinerators in England, 1998–2008: a study using matched case–control areas

Heavy Metals in Canned Tuna from Italian Markets

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