Maternal Regulation of Pups’ Cortical Activity: Role of Serotonergic Signaling

Courtiol, Emmanuelle; Wilson, Donald A.; Shah, Relish; Sullivan, Regina M.; Teixeira, Cátia M.

doi:10.1523/eneuro.0093-18.2018

Cited by 30 publications

(22 citation statements)

References 64 publications

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“…Generation of different frequency band oscillations occurs via different mechanisms; however, cross-frequency coupling between different bands can occur and greatly contributes to information encoding 53,54 . Our results further demonstrate that maternal behavior modulates these cortical LFP oscillations in a specific, behaviorally-dependent fashion 16,55 . However, adversityrearing modifies pup cortical response to these behavioral events at a developmentally critical time of attachment and cortical development 56,57 .…”

Section: Discussionsupporting

confidence: 70%

Adverse caregiving in infancy blunts neural processing of the mother

et al. 2020

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The roots of psychopathology frequently take shape during infancy in the context of parentinfant interactions and adversity. Yet, neurobiological mechanisms linking these processes during infancy remain elusive. Here, using responses to attachment figures among infants who experienced adversity as a benchmark, we assessed rat pup cortical local field potentials (LFPs) and behaviors exposed to adversity in response to maternal rough and nurturing handling by examining its impact on pup separation-reunion with the mother. We show that during adversity, pup cortical LFP dynamic range decreased during nurturing maternal behaviors, but was minimally impacted by rough handling. During reunion, adversityexperiencing pups showed aberrant interactions with mother and blunted cortical LFP. Blocking pup stress hormone during either adversity or reunion restored typical behavior, LFP power, and cross-frequency coupling. This translational approach suggests adversity-rearing produces a stress-induced aberrant neurobehavioral processing of the mother, which can be used as an early biomarker of later-life pathology.

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Section: Discussionsupporting

confidence: 70%

Adverse caregiving in infancy blunts neural processing of the mother

et al. 2020

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“…Generation of different frequency band oscillations occurs via different mechanisms; however, cross-frequency coupling between different bands can occur and greatly contributes to information encoding 68,69 . Our results further demonstrate that maternal behavior modulates these cortical LFP oscillations in a specific, behaviorally-dependent fashion 20,70 . However, adversity-rearing modifies pup cortical response to these behavioral events at a developmentally critical time of attachment and cortical development 71,72 .…”

Section: Figure 7 Differences In Maternal Behavior During Maltreatmesupporting

confidence: 70%

Adverse caregiving in infancy blunts neural processing of the mother: Translating across species

Opendak

Theisen

Blomkvist

et al. 2019

Preprint

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AbstractThe roots of psychopathology frequently take shape during infancy in the context of parent-infant interactions and adversity. Yet, neurobiological mechanisms linking these processes during infancy remain elusive. Here, using responses to attachment figures among infants who experienced adversity as a benchmark, we assessed rat pup cortical Local Field Potentials (LFP) and behaviors exposed to adversity in response to maternal rough and nurturing handling by examining its impact on pup separation-reunion with the mother. We show that during adversity, pup cortical LFP dynamic range decreased during nurturing maternal behaviors, but was minimally impacted by rough handling. During reunion, adversity-experiencing pups showed aberrant interactions with mother and blunted cortical LFP. Blocking pup stress hormone during either adversity or reunion restored typical behavior, LFP power, and cross-frequency coupling. This translational approach suggests adversity-rearing produces a stress-induced aberrant neurobehavioral processing of the mother, which can be used as an early biomarker of later-life pathology.

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“…First, the use of parent images, rather than physical parental presence, limits the ecological validity of the findings that will have to be interrogated in future research. Nonetheless, cues, such as maternal odors in rodent studies [16], or pictures of social support figures in humans [51] are frequently used in buffering studies, and many seminal studies examining the effect of the parent on brain function do not attempt to induce fear to examine parent effects [52]. Further, familiarity of parents versus strangers was not controlled in this study.…”

Section: Discussionmentioning

confidence: 99%

Decreased Amygdala Reactivity to Parent Cues Protects Against Anxiety Following Early Adversity: An Examination Across 3 Years

Callaghan

Gee

Gabard-Durnam

et al. 2019

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Background: The human brain remains highly plastic for a protracted developmental period. Thus, although early caregiving adversities that alter amygdala development can result in enduring emotion regulation difficulties, these trajectories should respond to subsequent enriched caregiving. Exposure to high quality parenting can regulate (e.g., decrease) children's amygdala reactivity, a process that, over the long-term, is hypothesized to enhance emotion regulation. We tested the hypothesis that, even following adversity, the parent-child relationship would be associated with amygdala decreases to parent cues, which would in turn predict lower future anxiety. Methods: Participants were 102 children (6-10 years old) and adolescents (11-17 years old), with one or two data points, that had experienced institutional care before adoption (PI; n=45) or lived with their biological parents (Comparison; n=57). We examined how amygdala reactivity to visual cues of the parent at Time 1 predicted longitudinal change (Time 1 to 2) in parent reported child anxiety across 3 years. Results: At Time 1, on average, amygdala reactivity decrements to parent cues were not seen in children that were PI but were seen in Comparison children. However, some children that were PI did show decreased amygdala to parent cues (~40%), which was associated with greater childreported feelings of security with their parent. Amygdala decreases at Time 1 were followed by steeper anxiety reductions from Time 1-2 (i.e., 3 years). Conclusions: These data provide a neurobiological mechanism by which the parent-child relationship can increase resilience, even in children at significant risk for anxiety symptoms.

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Maternal Regulation of Pups’ Cortical Activity: Role of Serotonergic Signaling

Abstract: Visual Abstract

Cited by 30 publications

References 64 publications

Adverse caregiving in infancy blunts neural processing of the mother

Adverse caregiving in infancy blunts neural processing of the mother

Adverse caregiving in infancy blunts neural processing of the mother: Translating across species

Decreased Amygdala Reactivity to Parent Cues Protects Against Anxiety Following Early Adversity: An Examination Across 3 Years

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