Maternal psychological distress after severe pregnancy hypertension was associated with increased child behavioural problems at the age of 12

Abstract

Aim: We examined the association between early maternal psychological distress after severe hypertensive disorders of pregnancy (HDP) and behavioural issues in their 12-yearold offspring.Methods: This secondary analyses of a prospective mother-child birth cohort focused on 95 women with severe HDP and their singleton offspring. The mothers were recruited during pregnancy from 2000 to 2003 in Amsterdam, the Netherlands. Maternal distress at child term age and three months post-term was measured using the Symptom Checklist-90. The Child Behaviour Checklist for six years to 18 years was used to quantify social and attention problems in their offspring at 12 years of age. Perinatal and neonatal risk factors were also analysed.Results: The children were born at a mean age of just under 32 weeks and 90% weighed below the 10th percentile. High psychological distress (score ≥133) affected 45% of the mothers at term age and 44% three months post-term. Child social problems were significantly associated with maternal distress at three months and were highest in cases of high maternal distress in combination with major neonatal morbidity. Child attention problems were associated with maternal anxiety at three months post-term.Conclusion: Early maternal psychological distress after severe maternal HDP was associated with childhood behavioural issues at the age of 12.

Pattern of Pro-Angiogenic Serum Placental Growth Factor in Gestational Hypertensive Women

“…Normal placental development is possible only under normal instruction of angiogenic processes; on the other hand, hypertensive developments are frequently associated with vascular 11 complaints. The role of placenta in hypertensive state of pregnancy is described by different previous 12,13 studies. A patterned appearance of the angiogenesis related factors is the requirement during pregnancy and changes in the pattern is the reason or result of vascular disorder.…”