Maternal protein intake during pregnancy is associated with child growth up to 5 years of age, but not through insulin-like growth factor-1: findings from the ROLO study

Geraghty, Aisling A.; O’Brien, Eileen C.; Alberdi, Goiuri; Horan, Mary K.; Donnelly, John A.; Larkin, Elizabeth; Segurado, Ricardo; Mehegan, John; Molloy, Eleanor J.

doi:10.1017/s0007114518002611

Cited by 17 publications

(19 citation statements)

References 36 publications

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“…We found that the increased body weight tended to diminish toward adulthood. This finding might be explained by the adaptation response, i.e., slower growth rate in the growing stage/fattening period of pigs [21]. Furthermore, we found that the IGF-1R protein content was increased, which was associated with elevated serum T3 levels at birth due to HP exposure.…”

Section: Discussionmentioning

confidence: 57%

“…It has been reported that hypothyroidism is closely linked to body weight and the growth rate of offspring in early life [ 37 – 39 ]. Indeed, a recent study revealed that maternal high-protein diet consumption during pregnancy causes elevated body weight of offspring at birth without changing the IGF-I pathway [ 21 ]. Similarly, we demonstrated that T3 and T4 levels in the serum were higher in the HP-exposed piglets with higher body weight.…”

Section: Discussionmentioning

confidence: 99%

“…In the case of large litters in pigs, the excess of dietary protein seems to be beneficial for preventing intrauterine growth retardation (IUGR) resulting from intrauterine crowding [20]. Notably, recent studies have revealed that maternal protein supplementation during gestation affects human fetal body weight independent of IGF-I [21]. In addition, hormones, especially those from the thyroid, are thought to be key players connecting the IGF growth axis and maternal factors/fetal nutrient supply.…”

Section: Introductionmentioning

confidence: 99%

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Maternal high-protein diet modulates hepatic growth axis in weaning piglets by reprogramming the IGFBP-3 gene

Cong

Zhang

et al. 2019

Eur J Nutr

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The aim of this study was to investigate the effects of maternal high dietary protein intake on the hepatic growth axis in offspring. Methods Fourteen primiparous purebred Meishan sows were fed either a standard-protein (SP, n = 7) diet or a high-protein (HP, 150% of SP, n = 7) diet during pregnancy. Offspring (one male and one female per group, n = 14) on day 70 of the embryonic stage and on days 1, 35 and 180 after birth were selected, weighed and killed. Serum samples were analyzed for Tch, insulin and insulin-like growth factor-binding protein 3 (IGFBP-3) levels. Liver samples were analyzed for IGFBP-3 and IGF-I mRNA expression by qRT-PCR and for IGFBP-3, IGF1R and growth hormone receptor (GHR) protein expression by Western blotting. The underlying mechanism of IGFBP-3 regulation was determined by methylated DNA immunoprecipitation (MeDIP) and chromatin immunoprecipitation (ChIP). Results High-protein exposure resulted in significantly higher body and liver weights of piglets, and it increased their serum T3 and T4 levels at birth and/or at weaning. Furthermore, the IGFBP-3 protein content in the liver and serum was significantly reduced in the HP-exposed weaning piglets, whereas at the transcriptional level IGFBP-3 mRNA expression was downregulated in the livers of HP group piglets. Finally, DNA hypermethylation and higher enrichment of the histone repressive marks H3K27me3 and H3K9me3 were observed. Conclusions Taken together, these results suggest that a maternal high-protein diet during gestation epigenetically reprograms IGFBP-3 gene expression to modulate the hepatic growth axis in weaning piglets.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal high-protein diet modulates hepatic growth axis in weaning piglets by reprogramming the IGFBP-3 gene

Cong

Zhang

et al. 2019

Eur J Nutr

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“…However, the effects of protein intake during pregnancy on FGR and LBW delivery have not been fully elucidated. Namely, meeting the minimum protein requirement may be helpful to prevent the risk of FGR [ 31 , 32 , 33 , 34 , 35 ], while a higher protein intake may do more harm than good [ 32 , 35 , 36 ]. It has been proposed that there is a quadratic (inverse U-curve) relationship between maternal protein intake and fetal growth [ 35 , 37 ], and moderate protein intake with an appropriate energy/protein balance is required to optimize fetal growth [ 35 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Albumin Redox State Is Associated with Infant Birth Weight in Japanese Pregnant Women

et al. 2021

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Background: Plasma albumin (ALB) reflects protein nutritional status in rats, but it is not clear whether it is associated with dietary protein insufficiency in pregnant women and/or their risk of low birth weight delivery. This study aimed to investigate whether maternal serum ALB redox state reflects maternal protein nutritional status and/or is associated with infant birth weights. Methods: The relationship between the serum reduced ALB ratio and infant birth weight was examined in an observational study of 229 Japanese pregnant women. A rat model simulating fetal growth restriction, induced by protein-energy restriction, was used to elucidate the relationship between maternal nutritional status, maternal serum ALB redox state, and birth weight of the offspring. Results: In the human study, serum reduced ALB ratio in the third trimester was significantly and positively correlated with infant birth weight. In the rat study, serum reduced ALB ratio and birth weight in the litter decreased as the degree of protein-energy restriction intensified, and a significant and positive correlation was observed between them in late pregnancy. Conclusions: Maternal serum reduced ALB ratio in the third trimester is positively associated with infant birth weight in Japanese pregnant women, which would be mediated by maternal protein nutritional status.

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“…Maternal nutrition during pregnancy can affect maternal health during pregnancy and beyond . It also influences the intrauterine environment of the developing fetus and this may influence the health and development of children in utero right through to adulthood . Therefore, nutrition during pregnancy is an important consideration in the management of pregnant women and in the overall life course approach to health care and health promotion.…”

Section: Introductionmentioning

confidence: 99%

PREgnancy Nutrition: A protocol for the development of a Core Outcome Set (PRENCOS)

Killeen

O’Brien

Jacob

et al. 2019

Intl J Gynecology & Obste

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Objective: To develop a Core Outcome Set (COS) for pregnancy nutrition research that is relevant to varied stakeholders and resource settings. Methods:This study has three distinct phases. The first phase involves generating a list of outcomes for consideration for the COS. This includes a systematic review of studies evaluating nutrition during pregnancy where all outcomes reported in relevant literature will be extracted. Qualitative interviews with currently or previously pregnant women will also be conducted. This step will supplement the findings of the systematic review by identifying additional outcomes of importance to this stakeholder group. In the second phase of the study, healthcare professionals, researchers, and mothers from various international resource settings will be invited to participate in a two-round modified Delphi survey. The aim of the survey is to gain consensus on which outcomes are most important to include in the COS. Finally, a face-face consensus meeting will be held with a select group of participants to finalize the COS. Conclusion:This COS will support standardization of outcome reporting in pregnancy nutrition research and ensure that selected outcomes are considered important by a variety of stakeholders. This will enhance the evidence behind nutrition interventions in pregnancy to improve outcomes for pregnant women. K E Y W O R D S

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Maternal protein intake during pregnancy is associated with child growth up to 5 years of age, but not through insulin-like growth factor-1: findings from the ROLO study

Cited by 17 publications

References 36 publications

Maternal high-protein diet modulates hepatic growth axis in weaning piglets by reprogramming the IGFBP-3 gene

Maternal high-protein diet modulates hepatic growth axis in weaning piglets by reprogramming the IGFBP-3 gene

Maternal Serum Albumin Redox State Is Associated with Infant Birth Weight in Japanese Pregnant Women

PREgnancy Nutrition: A protocol for the development of a Core Outcome Set (PRENCOS)

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