Maternal prenatal stress and placental gene expression of NR3C1 and HSD11B2: The effects of maternal ethnicity

Capron, Lauren; Ramchandani, Paul; Glover, Vivette

doi:10.1016/j.psyneuen.2017.10.019

Cited by 58 publications

(42 citation statements)

References 47 publications

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“…15,16 There is some evidence that ethnicity may play a role in how the placenta reacts to stress and therefore how this affects the developing fetus; for example, stress-related expression of the placental genes that regulate cortisol in the placenta was found in Caucasian women only. 17 Developing countries have the highest rates of DV, especially those in Africa. 15,18 This could be due to civil conflict as the 40% of countries in sub-Saharan Africa that have seen conflict have significantly higher rates of DV.…”

Section: Backg Rou N Dmentioning

confidence: 99%

“…Intimate partner or domestic violence is commonplace globally, an exposure more common than some other maternal health conditions more routinely checked for in prenatal screenings and is highly prevalent across both developed and developing countries, across ethnic groups and thought to be particularly common during pregnancy . There is some evidence that ethnicity may play a role in how the placenta reacts to stress and therefore how this affects the developing fetus; for example, stress‐related expression of the placental genes that regulate cortisol in the placenta was found in Caucasian women only . Developing countries have the highest rates of DV, especially those in Africa .…”

Section: Introductionmentioning

confidence: 99%

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Maternal exposure to violence and offspring neurodevelopment: A systematic review

Toso

Cock

Leavey

2020

Paediatric Perinatal Epid

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Background Stress during pregnancy is known to affect fetal neurodevelopment. It seems likely therefore that intimate partner violence (IPV) and domestic violence (DV) as extreme stressors will have a similarly adverse effect. Objectives A systematic review was conducted to assess the association between prenatal exposure to violence for mothers and developmental difficulties in their children. Data sources PubMed, PsycInfo, CINAHL, ERIC, Science Direct, SCOPUS, PsyARTICLES, Networked Digital Library of Theses and Dissertations, Women's Studies International and Gender Studies Database were all searched using the agreed search terms. Study selection and data extraction We include studies of women who have experienced any violence, fear of violence or aggression while pregnant, including emotional, psychological, physical or sexual violence in the context of IPV or DV. Studies were excluded if the neurodevelopmental outcomes of the offspring were not assessed. Studies from all countries were included, in English or translated to English, and search dates were not restricted. We included all years from inception of the database until the search date. Synthesis Study design and biases, assessment tools, management of confounding, results and overall quality were assessed. Results We identified 11 papers reporting on observational studies. Almost three quarters of the studies found a relationship between prenatal exposure to violence and developmental difficulties in the offspring. Differing assessment tools were used with a range of data collected and not all adjusted their findings for the same confounders. Conclusions Current evidence on the relationship between prenatal violence exposure, as IPV or DV, and consequent child developmental disorders remains limited. Future research using comprehensive study designs, larger samples and longitudinal follow‐up of the offspring could clarify this association. While maternal trauma resulting from exposure to violence may play an important role in childhood development disorders, additional intervening factors on the pathway need further explored.

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Section: Backg Rou N Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Maternal exposure to violence and offspring neurodevelopment: A systematic review

Toso

Cock

Leavey

2020

Paediatric Perinatal Epid

View full text Add to dashboard Cite

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“…Furthermore, levels of foetal cortisol during maternal stress are difficult to assess and the relationship between maternal and foetal cortisol can vary as a function of placental 11 beta-hydroxysteroid dehydrogenase 2 (HSD11B2) and P-glycoprotein levels (P-gp) 7 ( Figure 1). 73 Interestingly, previous rodent studies have shown that chronic prenatal stress results in increased DNA methylation at multiple CpG sites within the placental Hsd11b2 gene promoter, resulting in a down-regulation of placental transcription. 71 By contrast, sGC represent a poor substrate for HSD11B2, and so are not readily metabolised.…”

Section: Mechanis Ms Of Maternal Prog R Ammingmentioning

confidence: 99%

“…72 Recently, maternal prenatal stress has been associated with a down-regulation of placental HSD11B2, and that this effect is dependent on maternal ethnicity. 73 Interestingly, previous rodent studies have shown that chronic prenatal stress results in increased DNA methylation at multiple CpG sites within the placental Hsd11b2 gene promoter, resulting in a down-regulation of placental transcription. 74 This increase in methylation was associated with an increase in placental expression of Dnmt3a (DNA methyltransferase 3 alpha), an enzyme responsible for de novo DNA methylation.…”

Section: Mechanis Ms Of Maternal Prog R Ammingmentioning

confidence: 99%

Prenatal programming of stress responsiveness and behaviours: Progress and perspectives

Hamada

Matthews

2019

J Neuroendocrinology

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Parental exposure to stress or glucocorticoids either before or during pregnancy can have profound influences on neurodevelopment, neuroendocrine function and behaviours in offspring. Specific outcomes are dependent on the nature, intensity and timing of the exposure, as well as species, sex and age of the subject. Most recently, it has become evident that outcomes are not confined to first‐generation offspring and that there may be intergenerational and transgenerational transmission of effects. There has been intense focus on the mechanisms by which such early exposure leads to long‐term and potential transgenerational outcomes, and there is strong emerging evidence that epigenetic processes (histone modifications, DNA methylation, and small non‐coding RNAs) are involved. New knowledge in this area may allow the development of interventions that can prevent, ameliorate or reverse the long‐term negative outcomes associated with exposure to early adversity. This review will focus on the latest research, bridging human and pre‐clinical studies, and will highlight some of the limitations, challenges and gaps that exist in the field.

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“…Other studies have shown a dose response relationship between exposure to prenatal risk factors (including maternal depression), fearless temperament in early childhood and the development of offspring conduct problems and callous unemotional traits in adolescence [30]. As the human literature develops, complex biological and epigenetic mechanisms are discovered with sex-specific and ethnicity-specific effects reported [31,32]. Whilst it is recognised that the association between maternal depression and adverse offspring outcomes at least in part reflects shared genetic risk, genetically informative designs have shown that both genetic and environmental mechanisms contribute to the elevated risk of antisocial behaviour among the offspring of depressed parents [14,33].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal studies examining the impact of prenatal and subsequent episodes of maternal depression on offspring antisocial behaviour

Morgan

Channon

Penny

et al. 2019

Eur Child Adolesc Psychiatry

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Maternal depression is associated with adverse child outcomes including antisocial behaviour (ASB). Prospective longitudinal studies have focused on the timing and cumulative exposure to maternal depression to further delineate the association and mechanisms of effect. The objective of this systematic review was to synthesise and evaluate the findings of longitudinal studies of maternal depression and offspring antisocial behaviour. Three databases were searched (Psychinfo, Web of Science, and Medline). Twenty of 5936 studies met inclusion criteria. Study quality was assessed using the Critical Appraisal Skills Programme criteria [Critical Appraisal Skills Programme (2017) CASP (cohort observation checklist). https ://casp-uk. net/wpcon tent/uploa ds/2018/01/CASP-Cohor t-Study -Check list.pdf]. Results of individual studies were highly varied, using diverse analytical approaches and not all studies explored the independent effects of different episodes. Only three studies examined hypothesised mechanisms. Prenatal, postnatal, and later episodes of depression were all predictive of antisocial outcomes. One particular time period of depression exposure did not emerge as more predictive of offspring ASB than another. However, measures of maternal depression after the perinatal period were limited and typically included a one-off assessment of mothers' depressive symptoms that was concurrent to the assessment of offspring ASB. When cumulative exposure to maternal depression and specific timing effects were measured within the same study it was cumulative exposure that conferred the greatest risk for offspring ASB-particularly when this exposure began during the perinatal period. Findings are discussed in terms of limitations in the literature and highlight the need for future research to examine the biological and environmental mechanisms that underpin associations between maternal depression and offspring antisocial behaviour during different stages of development.

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Maternal prenatal stress and placental gene expression of NR3C1 and HSD11B2: The effects of maternal ethnicity

Abstract: These results support previous findings of an association between maternal prenatal stress and the expression of placental genes associated with the HPA-axis, but only in Caucasians. These ethnic specific findings are novel and require replication in different populations.

Cited by 58 publications

References 47 publications

Maternal exposure to violence and offspring neurodevelopment: A systematic review

Maternal exposure to violence and offspring neurodevelopment: A systematic review

Prenatal programming of stress responsiveness and behaviours: Progress and perspectives

Longitudinal studies examining the impact of prenatal and subsequent episodes of maternal depression on offspring antisocial behaviour

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