Maternal prenatal stress and infantile wheeze and asthma: The Osaka Maternal and Child Health Study

Kawamoto, Tetsuya; Miyake, Yoshihiro; Tanaka, Keiko; Nagano, Jun; Sasaki, Satoshi; Hirota, Yoshio

doi:10.1016/j.jpsychores.2020.110143

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…The stress hormones, including glucocorticoids, epinephrine, and norepinephrine, are thought to be involved in psychological stress-induced asthma exacerbation (147). A study of 763 Japanese mother-child pairs used 12 specific behavioral patterns as stress indicators and found that maternal chronic irritation and anger were associated with the risk of childhood asthma (148). In adolescents, stressors such as poverty, neighborhood stress, and school stress were individual predictors of emergency department visits for asthma (149).…”

Section: Mental Stressmentioning

confidence: 99%

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

Agache,

Akdis,

Akdis

et al. 2024

Front. Sci.

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Global warming and climate change have increased the pollen burden and the frequency and intensity of wildfires, sand and dust storms, thunderstorms, and heatwaves—with concomitant increases in air pollution, heat stress, and flooding. These environmental stressors alter the human exposome and trigger complex immune responses. In parallel, pollutants, allergens, and other environmental factors increase the risks of skin and mucosal barrier disruption and microbial dysbiosis, while a loss of biodiversity and reduced exposure to microbial diversity impairs tolerogenic immune development. The resulting immune dysregulation is contributing to an increase in immune-mediated diseases such as asthma and other allergic diseases, autoimmune diseases, and cancer. It is now abundantly clear that multisectoral, multidisciplinary, and transborder efforts based on Planetary Health and One Health approaches (which consider the dependence of human health on the environment and natural ecosystems) are urgently needed to adapt to and mitigate the effects of climate change. Key actions include reducing emissions and improving air quality (through reduced fossil fuel use), providing safe housing (e.g., improving weatherization), improving diets (i.e., quality and diversity) and agricultural practices, and increasing environmental biodiversity and green spaces. There is also a pressing need for collaborative, multidisciplinary research to better understand the pathophysiology of immune diseases in the context of climate change. New data science techniques, biomarkers, and economic models should be used to measure the impact of climate change on immune health and disease, to inform mitigation and adaptation efforts, and to evaluate their effectiveness. Justice, equity, diversity, and inclusion (JEDI) considerations should be integral to these efforts to address disparities in the impact of climate change.

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Section: Mental Stressmentioning

confidence: 99%

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

Agache,

Akdis,

Akdis

et al. 2024

Front. Sci.

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show abstract

“…Maternal behavior characterized by irritation and anger is linked to childhood asthma. 17 Some types of stressful events, such as job loss or chronic illness/disability, can reduce family income, worsen healthcare access, and require accepting poorer-quality housing with exposure to allergens, such as mold. 18 Breastfeeding benefits immune development and lowers the risk of allergic diseases, 19 but women who report more stress in their lives are less likely to breastfeed.…”

Section: Introductionmentioning

confidence: 99%

“…Stressful circumstances may disrupt childcare routines and compromise mother‐infant interaction. Maternal behavior characterized by irritation and anger is linked to childhood asthma 17 . Some types of stressful events, such as job loss or chronic illness/disability, can reduce family income, worsen healthcare access, and require accepting poorer‐quality housing with exposure to allergens, such as mold 18 .…”

Section: Introductionmentioning

confidence: 99%

A model of perinatal stress and childhood wheezing: ELSPAC‐CZ cohort

Štěpáníková

Thon

Mikeš

et al. 2021

Pediatric Pulmonology

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Background: Prenatal origins of wheezing are not fully understood. This study develops a model of mechanisms linking perinatal stress exposure to wheeze phenotypes in children.Methods: Data were obtained from 1880 mother-child dyads participating in ELSPAC-CZ birth cohort. Wheeze phenotypes assessed between birth and age 7 years included "never wheeze," "early-onset transient (EOT) wheeze," "early-onset persistent (EOP) wheeze," and "late-onset (LO) wheeze." Prenatal and postnatal stress exposures were assessed in mid-pregnancy and 6 months after delivery, respectively, using an inventory of 42 life events.Results: In adjusted models, children in the highest tercile (high) versus lowest tercile (low) for prenatal life events had a 38% higher risk of EOT wheeze (relative risk ratio [RRR] = 1.38; 95% confidence interval [CI] = 1.01-1.88; p = .041) and 50% higher risk of LO wheeze (RRR = 1.50; 95% CI = 1.00-2.25; p = .047). High versus low exposure to postnatal life events predicted a 60% increase in relative risk of EOT wheeze (RRR = 1.60; 95% CI = 1.17-2.19; p = .003) and medium versus low exposure was related to an 85% increase in relative risk of EOP wheeze (RRR = 1.85; 95% CI = 1.16-2.95; p = .010). Lower respiratory tract infections and postpartum depression partially mediated between postnatal life events and any wheeze (indirect effects 1.06, 95% CI = 1.02-1.09, p = .003 and odds ratio [OR] = 1.08, 95% CI = 1.02-1.15, p = .012, respectively), while postnatal events mediate for prenatal events (indirect effect OR = 1.11; 95% CI = 1.03-1.18; p = .005).Conclusions: Exposures to prenatal and postnatal life events are risk factors for the development of wheezing. Prenatal stress contributes to wheeze directly and also through postnatal life events, respiratory infections, and maternal depression.

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Folgeprobleme nach frühen traumatischen Erlebnissen

Straub

2022

Frühe Traumata Als Ursprung Von Chronischer Entzündung

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Maternal prenatal stress and infantile wheeze and asthma: The Osaka Maternal and Child Health Study

Cited by 4 publications

References 39 publications

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

A model of perinatal stress and childhood wheezing: ELSPAC‐CZ cohort

Folgeprobleme nach frühen traumatischen Erlebnissen

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