Maternal Prenatal Anxiety and Corticotropin-Releasing Hormone Associated With Timing of Delivery

Mancuso, Roberta; Schetter, Christine Dunkel; Rini, Christine; Roesch, Scott C.; Hobel, Calvin J.

doi:10.1097/01.psy.0000138284.70670.d5

Cited by 264 publications

(256 citation statements)

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“…Stress hormones also have been consistently associated with preterm delivery and shorter gestational periods (Hobel et al, 1999;Mancuso, Schetter, Rini, Roesch, & Hobel, 2004;Mullings et al, 2001;Sandman et al, 2006;Sandman et al, 1994;Wadhwa, Sandman, Porto, Dunkel-Schetter, & Garite, 1993). In addition, the timing of exposure to stress hormones during pregnancy may be critical in determining the length of gestation.…”

Section: Introductionmentioning

confidence: 99%

Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation

Ellman

Schetter

Hobel

et al. 2008

Developmental Psychobiology

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149

144

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The purpose of the study was to determine the specific periods during pregnancy in which human fetal exposure to stress hormones affects newborn physical and neuromuscular maturation. Blood was collected from 158 women at 15, 19, 25, and 31 weeks' gestation. Levels of placental corticotropin-releasing hormone (CRH) and maternal cortisol were determined from plasma. Newborns were evaluated with the New Ballard Maturation Score. Results indicated that increases in maternal cortisol at 15, 19, and 25 weeks and increases in placental CRH at 31 weeks were significantly associated with decreases in infant maturation among males (even after controlling for length of gestation). Results also suggested that increases in maternal cortisol at 31 weeks were associated with increases in infant maturation among females, although these results were not significant after controlling for length of gestation. Findings suggest that stress hormones have effects on human fetal neurodevelopment that are independent of birth outcome.

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Section: Introductionmentioning

confidence: 99%

Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation

Ellman

Schetter

Hobel

et al. 2008

Developmental Psychobiology

Self Cite

149

144

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“…5 Both psychosocial stress and neuroendocrine factors such as corticotrophin releasing hormone are associated with preterm delivery. 6 Analysing the differences in proportions of preterm deliveries between countries might increase our understanding of preterm delivery. Populations from different countries cannot be compared owing to different proportions of high risk pregnancies and parity, but using standard populations of primiparous women at low risk identified by the criteria described here could enable valid international comparisons of spontaneous preterm delivery rates to be made.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Preterm Delivery in Primiparous Women at Low Risk in Denmark: Population-Based Study

2006

Obstetrics & Gynecology

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Objectives To analyse trends in preterm delivery and the factors contributing to preterm delivery in Denmark. To construct a standard population at low risk (white European, 20-40 years of age, with a singleton spontaneous pregnancy) and describe the changes in this population so that time trends can be compared internationally. Design Population based study. Participants 99.8% of all deliveries in Denmark, 1995Denmark, -2004. Main outcome measures Proportion of babies born at less than 37 weeks' completed gestation for each year in the overall population and in a standard population at low risk. Results Overall, the proportion of preterm deliveries increased by 22% from 1995 to 2004. During the same period, known risk factors for preterm delivery such as in vitro fertilisation, multiple pregnancies, and elective deliveries also increased, and logistic regression analyses showed that these factors were associated with an increased risk of preterm delivery. Spontaneous preterm deliveries in primiparous women at low risk rose 51% (from 3.8% to 5.7%) during this time compared with 20% (2.7% to 3.2%) in multiparous women at low risk. Conclusions The overall proportion of preterm deliveries increased significantly from 1995 to 2004 and primiparity and multiple birth were the most important contributing factors. The rise in spontaneous preterm deliveries in the standard population of primiparous women at low risk was greater than in the total population.

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“…[7][8][9] En investigaciones previas se identificaron diferentes factores psicosociales como la expresión de estresores y su asociación. [11][12][13][14][15][16] Pero solo pocos estudios han explorado la relación entre el PPE, la ansiedad y el estrés. 17,18 Estos factores psicosociales involucrados definen al estrés como la relación entre la persona y el entorno, el cual es percibido por el individuo como algo impuesto que excede sus recursos, poniendo en peligro su bienestar, mientras que la ansiedad es un estado de agitación e inquietud desagradable caracterizado por la anticipación del peligro, el predominio de síntomas psíquicos y la sensación de catástrofe o de peligro inminente, es decir, la combinación entre síntomas cognitivos y fisiológicos, manifestando una reacción de sobresalto, donde el individuo trata de buscar una solución al peligro, por lo que el fenómeno es percibido con total nitidez.…”

Section: -5unclassified

Riesgo de Trabajo de parto pretérmino espontáneo y su relación con estrés y ansiedad

et al. 2014

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Resumen AbstractObjetivo: Determinar asociación de estrés, ansiedad y riesgo de trabajo de parto pretérmino espontáneo. Metodología: Es un estudio correlacional, longitudinal. El muestreo fue no probabilístico por casos consecutivos. A 124 mujeres embarazadas se les aplicó 2 instrumentos en tres semanas diferentes 20-24, 30-34 y 35-36. Uno evaluó el estado psicosocial de ansiedad con el instrumento "The Spielberger StateTrait Anxiety Inventory" (STAI) α de Cronbach de 0.90. Otro el estrés percibido con "Perceived Stress Questionnaire" (PSQ) α de Cronbach > 0.70. Resultados: La incidencia del parto pretérmino espontáneo (PPE) fue 6.4 %, el estrés percibido no incremento el riesgo PPE (RR 1.01; 95% [IC], 0.24-4.3 p < 0.05; La ansiedad no incremento el riesgo de PPE (RR 0.57; 95% [IC], 0.19-1.7 p < 0.05). Conclusión: El estrés percibido y la ansiedad no incrementaron el riesgo de PPE. Palabras clave: Parto pretérmino espontáneo. Estrés. Ansiedad. RISK OF SPONTANEOUS PRETERM DELIVERY AND ITS RELATIONSHIP TO STRESS AND ANXIETYTo determine the association of stress, anxiety and risk of spontaneous preterm delivery. Methodology: This study is correlational, longitudinal. The sampling was not probabilistic consecutive cases. 124 women pregnant were applied two different instruments in three different weeks 20-24, 30-34, 35-36. The first one to see the psychosocial status of the anxiety using instrument "The Spielberger State-Trait anxiety Inventory" (STAI), Cronbach's alpha 0.90. And the perceived stress with the "Perceived Stress Questionnaire" (PSQ) Cronbach's alpha > 0.70. Results: The incidence of spontaneous preterm delivery was 6.4 %, perceived stress did not increase the risk of spontaneous preterm delivery ( RR 1.01, confidence interval 95% [CI], 0.24 -4.3 p < 0.05; Anxiety did not increase the risk of spontaneous preterm delivery ( RR 0.57, 95% [CI], 0.19-1.7 p <0.05). Conclusion: The perceived stress and anxiety did not increase the risk of spontaneous preterm delivery.

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Maternal Prenatal Anxiety and Corticotropin-Releasing Hormone Associated With Timing of Delivery

Abstract: These findings are the first to link both psychosocial and neuroendocrine factors to birth outcomes in a prospective design.

Cited by 264 publications

References 32 publications

Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation

Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation

Spontaneous Preterm Delivery in Primiparous Women at Low Risk in Denmark: Population-Based Study

Riesgo de Trabajo de parto pretérmino espontáneo y su relación con estrés y ansiedad

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