Maternal Preeclampsia and Neonatal Outcomes

Backes, Carl H.; Markham, Kara B.; Moorehead, Pamela A.; Cordero, Leandro; Nankervis, Craig A.; Giannone, Peter J.

doi:10.1155/2011/214365

Cited by 378 publications

(332 citation statements)

References 91 publications

(87 reference statements)

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“…1 In the Western world, the organized prenatal care has decreased maternal mortality, but the risk is often passed on to the fetus in the form of a premature birth. 2 Preeclampsia has characteristics similar to vascular disorder, such as reduced placental perfusion and hypertension, along with endothelial dysfunction and proteinuria. 1 Clinical observations suggest that earlyonset and late-onset disease types can be separated in origin, even though individual cases share characteristics.…”

Section: Introductionmentioning

confidence: 99%

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18

et al. 2013

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Pre-eclampsia is a common vascular disorder of pregnancy. It originates in the placenta and targets the maternal endothelium. According to epidemiological research, 450% of the liability to this disorder can be accounted for by genetic factors. Both maternal and fetal genes contribute to the risk, but especially the fetal genetic risk profile is still poorly understood. We have previously detected linkage signals in multiplex Finnish families on chromosomes 2p25, 4q32, and 9p13 using maternal phenotypes. We performed a linkage analysis using updated maternal phenotypes and an unprecedented linkage analysis using fetal phenotypes. Markers genotyped were available from 237 individuals in 15 Finnish families, including 72 affected mothers and 49 affected fetuses. The MERLIN software was used for sample and marker quality control and linkage analysis. The results were compared against the original ones obtained by using the GENEHUNTER 2.1 software. The previous identification of the maternal susceptibility locus to a genetic location at 21.70 cM near marker D2S168 on chromosome 2 was confirmed by using both maternal and fetal phenotypes (maternal non-parametric linkage (NPL) score 3.79, P ¼ 0.00008, LOD (logarithm (base 10) of odds) ¼ 2.20 and fetal NPL score 2.95, P ¼ 0.002, LOD ¼ 1.71). As a novel finding, we present a suggestive linkage to chromosome 18 at 86.80 cM near marker D18S64 (NPL score 2.51, P ¼ 0.006, LOD ¼ 1.20) using the fetal phenotype. We propose that chromosome 18 may harbor a new fetal susceptibility locus for pre-eclampsia.

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Section: Introductionmentioning

confidence: 99%

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18

et al. 2013

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“…Preeclampsia is influenced by nulliparity, age and race (1,4). This disease remains a great challenge even to the most experienced obstetricians because there are no effective interventions to treat or prevent it and antenatal care involves a difficult balance between the risks for mother to continue the pregnancy and the risks for the baby's preterm birth.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Laboratory Disorders in Admitted Neonates in NICU Who Were Born to Preeclamptic Mothers

Mosayebi¹,

Nariman²,

Hosseini³

et al. 2013

J Compr Ped

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Background: Preeclampsia is a major cause of maternal, fetal and neonatal morbidity and mortality. Objectives: The aim of this study was to determine the laboratory disorders in neonates born to preeclamptic mothers. Patients and Methods: This descriptive-retrospective study was conducted in the neonatal units of Shahid Beheshti and Shabihkhani Hospitals on neonates born to preeclamptic mothers during 2009 -2012. Neonatal data including gestational age, gender, mode of delivery, birth weight and laboratory reports were extracted from their medical records and analyzed. Results: A total of 2600 newborns were admitted during the study period, of which 84 infants were born to mothers with preeclampsia. The laboratory disorders were neutropenia in 32 cases (37%), anemia in 33 (39.2%), leucopenia in 24 (28.5%), thrombocytopenia in 23 (27.3%), hypoglycemia in 28 (33.3%), hypocalcemia in 22 (26.1%) and hyperbilirubinemia in 33 (39.2%) patients. Thirty one infants (35.6%) had positive cultures .Twenty nine patients (35%) developed coagulative disorders with prolonged PT and PTT. Evaluation of ABG showed 16 infants (19%) with metabolic acidosis, 23 (27.3%) hypoxia and 24 (28.5%) respiratory acidosis cases. All the laboratory abnormalities were more common in preterm and low birth-weight-infants. Conclusions: Early detection and timely management of laboratory disorders in preeclamptic infants may lead to improvement of the neonatal outcomes.

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“…However, in advanced cases, the umbilical artery shows absent or reversed diastolic flow. In such a situation, there is decompensation, worsening fetal hypoxia and acidosis, ultimately leading to imminent intra-uterine demise [4].…”

Section: Introductionmentioning

confidence: 99%

USG Doppler Study of Uterine, Umbilical and Foetal Middle Cerebral Arteries Among Severe Pre-Eclamptic Women and their Relation to Perinatal Outcomes

Vedaraju¹

2016

IJARS

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Introduction: Pre-eclampsia is a condition in pregnancy characterized by the onset of hypertension and proteinuria after 20 weeks of gestation. This affects multiple organs in mother and also has a significant impact on the fetus. The extensive changes caused by pre-eclampsia result in complications leading to fetal jeopardy, such as placental abruption, fetal growth restriction, pre-term birth, respiratory distress and Intra uterine demise (IUD). The definitive treatment of pre-eclampsia is termination of pregnancy and initiation of treatment is crucial. Doppler ultrasonography (USG) is non-invasive and can be done along with the routine obstetric scans and is therefore considered safe and suitable for the study of blood flow alterations caused by severe pre-eclampsia. Not only would it serve as a predictive tool, it would also help plan subsequent management of the pregnancy, based on fetal health. Aim:To study the changes in uterine, umbilical and foetal middle cerebral arteries in severe pre-eclampsia, using Doppler ultrasonography and to provide basis for use of Doppler tests in directing treatment protocol of severe pre-eclampsia

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Maternal Preeclampsia and Neonatal Outcomes

Cited by 378 publications

References 91 publications

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18

Evaluation of Laboratory Disorders in Admitted Neonates in NICU Who Were Born to Preeclamptic Mothers

USG Doppler Study of Uterine, Umbilical and Foetal Middle Cerebral Arteries Among Severe Pre-Eclamptic Women and their Relation to Perinatal Outcomes

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