Maternal predictors of intrauterine growth restriction

Cetin, Irene; Mandò, Chiara; Calabrese, Stefania

doi:10.1097/mco.0b013e32835e8d9c

Cited by 69 publications

(44 citation statements)

References 75 publications

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“…6 Environmental factors, nutritional status and diet of the mother also affect fetal development. 7 Alterations in the nutrient supply to the fetus result in nutrient deprivation, causing restricted growth. 7 LBW is a major underlying cause of infant mortality and childhood morbidity.…”

Section: Bmj Global Healthmentioning

confidence: 99%

“…7 Alterations in the nutrient supply to the fetus result in nutrient deprivation, causing restricted growth. 7 LBW is a major underlying cause of infant mortality and childhood morbidity. 8 Additionally, there is a clear association between LBW and increased risk for many diseases later in life, such as metabolic syndrome, diabetes mellitus type 2, cardiovascular diseases, hypertension or cancer.…”

Section: Bmj Global Healthmentioning

confidence: 99%

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Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

et al. 2017

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IntroductionLow birth weight (LBW, birth weight less than 2500 g) is associated with infant mortality and childhood morbidity. Poor maternal nutritional status is one of several contributing factors to LBW. We systematically reviewed the evidence for nutrition-specific (addressing the immediate determinants of nutrition) and nutrition-sensitive (addressing the underlying cause of undernutrition) interventions to reduce the risk of LBW and/or its components: preterm birth (PTB) and small-for-gestational age (SGA).MethodsWe conducted a comprehensive literature search in MEDLINE, EMBASE, CINAHL and the Cochrane Database of Systematic Reviews (September 2015). Systematic reviews of randomised controlled trials focusing on nutritional interventions before and during pregnancy to reduce LBW and its components were eligible for inclusion into the overview review. We assessed the methodological quality of the included reviews using A Measurement Tool to Assess Reviews (AMSTAR), PROSPERO: CRD42015024814.ResultsWe included 23 systematic reviews which comprised 34 comparisons. Sixteen reviews were of high methodological quality, six of moderate and only one review of low quality. Six interventions were associated with a decreased risk of LBW: oral supplementation with (1) vitamin A, (2) low-dose calcium, (3) zinc, (4) multiple micronutrients (MMN), nutritional education and provision of preventive antimalarials. MMN and balanced protein/energy supplementation had a positive effect on SGA, while high protein supplementation increased the risk of SGA. High-dose calcium, zinc or long-chain n-3 fatty acid supplementation and nutritional education decreased the risk of PTB.ConclusionImproving women’s nutritional status positively affected LBW, SGA and PTB. Based on current evidence, especially MMN supplementation and preventive antimalarial drugs during pregnancy may be considered for policy and practice. However, for most interventions evidence was derived from a small number of trials and/or participants. There is a need to further explore the evidence of nutrition-specific and nutrition-sensitive interventions in order to reach the WHO’s goal of a 30% reduction in the global rate of LBW by 2025.

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Section: Bmj Global Healthmentioning

confidence: 99%

Section: Bmj Global Healthmentioning

confidence: 99%

Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

et al. 2017

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“…Consumption of a varied and balanced diet, as evidenced for the "New Nordic Diet" [29] or Mediterranean-type diets [30], has been associated with maternal well-being and a favourable pregnancy outcome, and with the offspring's longterm health. It has been shown that macro-and micronutrients are direct regulators of DNA stability and may have an impact on phenotype modifications by influencing epigenetic processes [31,32].…”

Section: Nutrient Supply and Early Programmingmentioning

confidence: 99%

Impact of Micronutrient Status during Pregnancy on Early Nutrition Programming

et al. 2019

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Background: Nutrition status prior to conception and during pregnancy and infancy seems to have an influence on the disease risk in adulthood (early nutrition/developmental programming). We aimed to review the current knowledge on the role of micronutrients in early nutrition programming and its implications for healthcare. Summary of Findings: Globally and even in high-income countries where a balanced diet is generally accessible, an inadequate maternal micronutrient status is common. This may induce health problems in the mother and foetus/newborn both immediately and in later life. Pregnant women and those who may become pregnant should aim to achieve a satisfactory micronutrient status from a well-balanced diet, and where necessary from additional supplements. Key Messages: We emphasise the need for a call to action for healthcare providers and policymakers to better educate women of child-bearing age regarding the short- and long-term benefits of an appropriate micronutrient status. The role of micronutrient status in early nutrition programming needs to be emphasized more to address the still limited awareness of the potential long-term health repercussions of suboptimal micronutrient supply during pregnancy.

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“…Alcohol and tobacco exposure during development affect the expression of genes involved in cell cycle control, apoptosis, and transcriptional regulation, mostly through epigenetic mechanisms [332,333]. Alcohol, tobacco, and caffeine exposure are associated with adverse maternal and child health outcomes [269].…”

Section: Consensus Recommendationsmentioning

confidence: 99%

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

Brenner

Charlton

Luyckx

et al. 2017

Nephron

119

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Hypertension and chronic kidney disease (CKD) have a significant impact on global morbidity and mortality. The Low Birth Weight and Nephron Number Working Group has prepared a consensus document aimed to address the relatively neglected issue for the developmental programming of hypertension and CKD. It emerged from a workshop held on April 2, 2016, including eminent internationally recognized experts in the field of obstetrics, neonatology, and nephrology. Through multidisciplinary engagement, the goal of the workshop was to highlight the association between fetal and childhood development and an increased risk of adult diseases, focusing on hypertension and CKD, and to suggest possible practical solutions for the future. The recommendations for action of the consensus workshop are the results of combined clinical experience, shared research expertise, and a review of the literature. They highlight the need to act early to prevent CKD and other related noncommunicable diseases later in life by reducing low birth weight, small for gestational age, prematurity, and low nephron numbers at birth through coordinated interventions. Meeting the current unmet needs would help to define the most cost-effective strategies and to optimize interventions to limit or interrupt the developmental programming cycle of CKD later in life, especially in the poorest part of the world.

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Maternal predictors of intrauterine growth restriction

Cited by 69 publications

References 75 publications

Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews

Impact of Micronutrient Status during Pregnancy on Early Nutrition Programming

The Impact of Kidney Development on the Life Course: A Consensus Document for Action

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