Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation

Kim, Ju Hyeon; Barbagallo, Belinda; Annunziato, Kate M.; Farias-Pereira, Renalison; Doherty, Jeffery; Lee, Jong-Hwa; Zina, Jake M.; Tindal, Cole; McVey, Cailin; Aresco, Racheal; Johnstone, Megan; Sant, Karilyn E.; Timme‐Laragy, Alicia R.; Park, Yeonhwa; Clark, J. Marshall

doi:10.1016/j.fct.2021.112153

Cited by 13 publications

(6 citation statements)

References 57 publications

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“…The combination of heat shock elements (HSEs) and heat shock factors was critical for the ability of cells to recover from stress. Multiple studies showed that exposure to PFOS upregulated heat shock protein 70 (hsp70), which affected antioxidant defense mechanisms, and it may be related to delayed development and weight loss later in life . Compounds with sulfonic acid groups in 11 PFAS all showed positive results for SR-HSE, indicating that the sulfonic acid groups could be related to the upregulation of heat shock protein 70 (hsp70).…”

Section: Resultsmentioning

confidence: 99%

“…Multiple studies showed that exposure to PFOS upregulated heat shock protein 70 (hsp70), 51 which affected antioxidant defense mechanisms, 52 and it may be related to delayed development and weight loss later in life. 53 Compounds with sulfonic acid groups in 11 PFAS all showed positive results for SR-HSE, indicating that the sulfonic acid groups could be related to the upregulation of heat shock protein 70 (hsp70). However, the related mechanism has not yet been investigated to prove this hypothesis.…”

Section: ■ Introductionmentioning

confidence: 99%

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Comprehensive Exposure Studies of Per- and Polyfluoroalkyl Substances in the General Population: Target, Nontarget Screening, and Toxicity Prediction

Wang

et al. 2022

Environ. Sci. Technol.

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Novel per- and polyfluoroalkyl substances (PFASs) in the environment and populations have received extensive attention; however, their distribution and potential toxic effects in the general population remain unclear. Here, a comprehensive study on PFAS screening was carried out in serum samples of 202 individuals from the general population in four cities in China. A total of 165 suspected PFASs were identified using target and nontarget analysis, including seven identified PFAS homolog series, of which 16 PFASs were validated against standards, and seven PFASs [4:2 chlorinated polyfluorinated ether sulfonate (4:2 Cl-PFESA), 7:2 chlorinated polyfluorinated ether sulfonate (7:2 Cl-PFESA), hydrosubstituted perfluoroheptanoate (H-PFHpA), chlorine-substituted perfluorooctanoate (Cl-PFOA), chlorine-substituted perfluorononanate (Cl-PFNA), chlorine-substituted perfluorodecanoate (Cl-PFDA), and perfluorodecanedioic acid (PFLDCA n = 8)] were reported for the first time in human serum. The Tox21-GCN model (a graph convolutional neural network model based on the Tox21 database) was established to predict the toxicity of the discovered PFASs, revealing that PFASs containing sulfonic acid groups exhibited multiple potential toxic effects, such as estrogenic effects and stress responses. Our study indicated that the general population was exposed to various PFASs, and the toxicity prediction results of individual PFASs suggested potential health risks that could not be ignored.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Comprehensive Exposure Studies of Per- and Polyfluoroalkyl Substances in the General Population: Target, Nontarget Screening, and Toxicity Prediction

Wang

et al. 2022

Environ. Sci. Technol.

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“…This figure is still close to or even exceeds the PFOS HBM-I value of 5 ng PFOS/mL blood plasma established by the German Human Biomonitoring Committee [ 17 ]. For human epidemiological studies and experimental animal studies, exposure to PFOS has been shown to have a variety of health effects on the body, such as hepatotoxicity, infertility, altered thyroid function, decreased immunity, neurotoxicity, developmental toxicity, reproductive toxicity, nephrotoxicity, cardiotoxicity, insulin resistance, and carcinogenic effects [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Data published by the European Food Safety Agency (EFSA) in 2012 showed that the estimated daily dietary intake of PFOS for adults was 5.2–10 ng/kg body weight (bw) [ 26 ].…”

Section: Profile Of Pfosmentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to PFOS, and can have adverse effects on human health. Increasing research shows that the liver is the major target of PFOS, and that PFOS can damage liver tissue and disrupt its function; however, the exact mechanisms remain unclear. In this study, we reviewed the adverse effects of PFOS on liver tissue and cells, as well as on liver function, to provide a reference for subsequent studies related to the toxicity of PFOS and liver injury caused by PFOS.

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“…PFOA: [288] PFOS: [289] Summary table of obesogenic activity testing in the zebrafish, medaka, roundworm, and fruit fly models.…”

Section: Speciesmentioning

confidence: 99%

Obesity III: Obesogen assays: Limitations, strengths, and new directions

Kassotis

Saal

Babin

et al. 2022

Biochemical Pharmacology

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Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation

Cited by 13 publications

References 57 publications

Comprehensive Exposure Studies of Per- and Polyfluoroalkyl Substances in the General Population: Target, Nontarget Screening, and Toxicity Prediction

Comprehensive Exposure Studies of Per- and Polyfluoroalkyl Substances in the General Population: Target, Nontarget Screening, and Toxicity Prediction

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Obesity III: Obesogen assays: Limitations, strengths, and new directions

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