Abstract:Objective. To estimate the association between maternal pre-pregnant body mass index (BMI) and maternal weight change during pregnancy and offspring birthweight using the BMI classification developed by World Health Organization (WHO) and adopted by the Institute of Medicine (IOM) 3), mean maternal weight change in the first 30 weeks of gestation was 9.3kg (SD 4.4), mean birthweight was 3675g (SD 487) and mean age 30.3 years. Of the women, 65.2% had a normal pre-pregnancy weight, 2.9% were underweight, 22.3% … Show more
“…In a previous study, pre-pregnancy BMI and GWC were positively associated with offspring birth weight. 19 However, in our study and a previous adjustment for the effect mediated through birth weight attenuated the effect of GWC. 9 GWC may be linked to offspring BMI through several pathways.…”
Section: 4713contrasting
confidence: 71%
“…2,[10][11][12]17,18 In a previous study, we estimated the association between maternal pre-pregnancy BMI and maternal GWC with birth weight as the main outcome and found that offspring birth weight increased with both increasing maternal pre-pregnancy BMI and GWC during pregnancy in all six pre-pregnancy BMI categories based on World Health Organization (WHO) classifications. 19 It is thus important to further explore to what extent these findings are pertinent to children later in life.…”
OBJECTIVE:To estimate the associations between maternal pre-pregnancy body mass index (BMI) or gestational weight change (GWC) during pregnancy and offspring BMI at 3 years of age, while taking several pre-and postnatal factors into account. DESIGN: The Norwegian Mother and Child Cohort Study is a population-based pregnancy cohort study of women recruited from all geographical areas of Norway. SUBJECTS: The study includes 31 169 women enrolled between 2000 and 2009 through a postal invitation sent to women at 17-18 weeks of gestation. Data collected from 5898 of the fathers were included. MAIN OUTCOME MESURES: Offspring BMI at 3 years was the main outcome measured in this study. RESULTS: Mean maternal pre-pregnancy BMI was 24.0 kg m À 2 (s.d. 4.1), mean GWC in the first 30 weeks of gestation was 9.0 kg (s.d. 4.1) and mean offspring BMI at 3 years of age was 16.1 kg m À 2 (s.d. 1.5). Both maternal pre-pregnancy BMI and GWC were positively associated with mean offspring BMI at 3 years of age. Pre-pregnancy BMI and GWC also interacted, and the strength of the interaction between these two factors was strongly associated with the increase in offspring BMI among mothers who gained the most weight during pregnancy and had the highest pre-pregnancy BMI. Our findings show that results could be biased by not including pre-pregnant paternal BMI.
CONCLUSION(S):This large population-based study showed that both maternal pre-pregnancy BMI and GWC were positively associated with mean offspring BMI at 3 years of age.
“…In a previous study, pre-pregnancy BMI and GWC were positively associated with offspring birth weight. 19 However, in our study and a previous adjustment for the effect mediated through birth weight attenuated the effect of GWC. 9 GWC may be linked to offspring BMI through several pathways.…”
Section: 4713contrasting
confidence: 71%
“…2,[10][11][12]17,18 In a previous study, we estimated the association between maternal pre-pregnancy BMI and maternal GWC with birth weight as the main outcome and found that offspring birth weight increased with both increasing maternal pre-pregnancy BMI and GWC during pregnancy in all six pre-pregnancy BMI categories based on World Health Organization (WHO) classifications. 19 It is thus important to further explore to what extent these findings are pertinent to children later in life.…”
OBJECTIVE:To estimate the associations between maternal pre-pregnancy body mass index (BMI) or gestational weight change (GWC) during pregnancy and offspring BMI at 3 years of age, while taking several pre-and postnatal factors into account. DESIGN: The Norwegian Mother and Child Cohort Study is a population-based pregnancy cohort study of women recruited from all geographical areas of Norway. SUBJECTS: The study includes 31 169 women enrolled between 2000 and 2009 through a postal invitation sent to women at 17-18 weeks of gestation. Data collected from 5898 of the fathers were included. MAIN OUTCOME MESURES: Offspring BMI at 3 years was the main outcome measured in this study. RESULTS: Mean maternal pre-pregnancy BMI was 24.0 kg m À 2 (s.d. 4.1), mean GWC in the first 30 weeks of gestation was 9.0 kg (s.d. 4.1) and mean offspring BMI at 3 years of age was 16.1 kg m À 2 (s.d. 1.5). Both maternal pre-pregnancy BMI and GWC were positively associated with mean offspring BMI at 3 years of age. Pre-pregnancy BMI and GWC also interacted, and the strength of the interaction between these two factors was strongly associated with the increase in offspring BMI among mothers who gained the most weight during pregnancy and had the highest pre-pregnancy BMI. Our findings show that results could be biased by not including pre-pregnant paternal BMI.
CONCLUSION(S):This large population-based study showed that both maternal pre-pregnancy BMI and GWC were positively associated with mean offspring BMI at 3 years of age.
“….should we work to understand mechanistically how birth weight and fetal growth are related to leukemia risk?" (23) Evidently maternal prepregnancy weight and pregnancy weight gain are associated with the birth weight of baby (24). Perhaps, birth weight reflects, in part, maternal circadian disruption which leads to her elevated weight.…”
Section: Circadian Gene Expression and Actionmentioning
Incidence of cancer in children has increased in recent decades, and known risk factors can account for only a small minority of cases. Gestation and early childhood are particularly vulnerable periods in human development and an important aspect of development is in circadian rhythmicity. Emerging evidence implicates the molecular circadian mechanism in a vast array of other physiologic functions including metabolism, DNA damage response and cell-cycle regulation. Electric light exposure at night can disrupt circadian rhythms and, thereby, many other physiologic processes that are under circadian control. On this basis, it is proposed that illtimed electric light exposure to pregnant women, to neonates, infants, and small children may increase cancer risk in those children. There are practical implications and interventions that accrue from this idea should it later be confirmed to be true. Cancer Epidemiol Biomarkers Prev; 21(5);
“…As we know, it has been widely recognized that maternal pre-pregnancy body mass index (pre-BMI) and gestational weight gain are closely associated with pregnancy outcomes including neonatal birth weight (NBW) (Stamnes Koepp et al, 2012;Li et al, 2014). In 2009, the Institute of Medicine (IOM) of America introduced a guideline concerning appropriate maternal weight gain during different trimesters for singleton pregnancy, which may result in a better pregnancy outcome (Oken et al, 2009).…”
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