Maternal Pre‐pregnancy Body Mass Index and Gestational Weight Gain in Relation to Autism Spectrum Disorder and other Developmental Disorders in Offspring

Windham, Gayle C.; Anderson, Meredith; Lyall, Kristen; Daniels, Julie L.; Kral, Tanja V.E.; Croen, Lisa; Levy, Susan E.; Bradley, Chyrise B.; Cordero, Christina; Young, Lisa; Schieve, Laura A.

doi:10.1002/aur.2057

Cited by 39 publications

(57 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…*Represents recurrence risk. Figure adapted from 18 with added findings from select reviews and empirical papers: neonatal hypoxia estimate 267 , childhood vaccines 20 , valporate use during pregnancy 268 , parent age estimates 269 , preterm birth estimate 270,271 , maternal obesity estimate 272 , folic acid intake estimate 273 , siblings estimate 274,275 , interpregnancy interval estimate 276 , assisted reproductive technologies estimate 277,278 , pesticide and air pollution estimate 279 , caesarian section estimate 280 . Simplified schematic of the major cellular components of a neural circuit in the cerebral cortex, with a focus on pyramid-shaped glutamatergic excitatory projection neurons.…”

Section: Supportsmentioning

confidence: 99%

Autism spectrum disorder

Lord

Brugha

Charman

et al. 2020

Nat Rev Dis Primers

993

741

View full text Add to dashboard Cite

Autism Spectrum Disorder (ASD) is a construct used to describe individuals with a specific combination of impairments in social communication and repetitive behaviours, highly restricted interests and/or sensory behaviours beginning early in life. The worldwide prevalence of autism is just under 1%, but estimates are higher in high-resource countries. Although gross brain pathology is not characteristic of autism, subtle anatomical and functional differences have been observed in postmortem, neuroimaging and electrophysiological studies. Initially it was hoped that accurate measurement of behavioural phenotypes would lead to specific genetic subtypes, but genetic findings have mainly applied to heterogeneous groups that are not specific to autism. Psychosocial interventions in children can improve specific behaviours, such as joint attention, language and social engagement that may affect further development and could reduce symptom severity. However, further research is necessary to identify the long-term needs and treatments and the mechanisms behind them that could result in improved independence and quality of life over time. Families are often the major source of support for people with AUTISM throughout much of life and need to be considered, along with the perspectives of autistic persons, in both research and practice. [H1] Introduction Autism spectrum disorder (ASD) is a common, highly heritable and heterogeneous neurodevelopmental disorder that has underlying cognitive features and commonly co-occurs with other conditions. The Autism spectrum disorder-or autism-is a neurodevelopmental disorder that typically manifests in young children. This Primer by Lord and colleagues reviews the epidemiology, mechanisms, clinical detection and treatment of autism.

show abstract

Section: Supportsmentioning

confidence: 99%

Autism spectrum disorder

Lord

Brugha

Charman

et al. 2020

Nat Rev Dis Primers

993

741

View full text Add to dashboard Cite

show abstract

“…Numerous studies have posited adverse effects of intrauterine inflammatory signals to explain the associations consistently observed between elevated maternal BMI and risk for ASD (52)(53)(54)(55). Here we report that maternal BMI was not associated with APPs in cases or controls measured only a few days after birth, raising the question of whether this particular mechanism to link maternal BMI to risk of ASD is relevant, at least in later pregnancy.…”

Section: Discussionmentioning

confidence: 56%

Neonatal levels of acute phase proteins and risk of autism spectrum disorders

Gardner

Lee

Brynge

et al. 2020

Preprint

View full text Add to dashboard Cite

+46 70 355 57 56 Word count (text only): 3010 Display items: 1 Table, 4 figures, 12 eFigures, 7 eTables References: 55Running Title: Neonatal acute phase proteins and autism spectrum disorders Abstract Background: Immune signaling pathways influence neurodevelopment and are hypothesized to contribute to the etiology of autism spectrum disorders (ASD). We aimed to assess risk of ASD in relation to levels of neonatal acute phase proteins, key components of innate immune function, measured in neonatal dried blood spots.Method: We included 924 ASD cases, 1092 unaffected population-based controls, and 203 unaffected siblings to ASD cases in this case-control study nested within the register-based Stockholm Youth Cohort. Concentrations of nine different acute phase proteins were measured in eluates from neonatal dried blood spots from cases, controls, and siblings using a bead-based multiplex assay.Results: C reactive protein was consistently associated with odds of ASD in case-control comparisons, with higher odds associated with the highest quintile compared to the middle quintile (OR 1.50, 95% CI 1.10 -2.04) in adjusted analyses. In contrast, the lowest quintiles of alpha-2-macroglobulin (3.71, 1.21 -11.33), ferritin (4.20, 1.40 -12.65), and Serum Amyloid P (3.05, 1.16 -8.01) were associated with odds of ASD in the matched sibling comparison. Neonatal acute phase proteins varied with perinatal environmental factors and maternal/fetal phenotypes. Significant interactions in terms of risk for ASD were observed between neonatal acute phase proteins and maternal infection in late pregnancy, maternal anemia, and maternal psychiatric history.Conclusions: Indicators of the neonatal innate immune response are associated with risk for ASD, though the nature of these associations varies considerably with factors in the perinatal environment and the genetic background of the comparison group.We implemented a case-finding procedure covering all pathways to child and adolescent psychiatric care and habilitation services in Stockholm County (20,21). Ascertainment of ASD, ID, and ADHD in the SYC is described in Table S1. The outcome of ASD was stratified by presence of co-occurring ADHD and ID: ASD with ID, ASD with ADHD, and ASD without ID or ADHD (ASD only). Individuals diagnosed with both co-occurring ID and ADHD (n=111) were included in the ASD with ID group. Laboratory analysisNeonatal dried blood spots (NDBS) were collected from the national biobank at Karolinska University Hospital, Solna. Blood spots were originally collected at approximately 3-5 days after birth (mean=4.1 days, SD=1.3). We selected a smaller sample (born 1998-2000) of the NDBS collected for analysis of immune markers. A sample (12.5 %) of those born 1996-1997 was also included. Our final sample consisted of 924 ASD cases and 1092 controls, as well as 203 unaffected siblings to ASD cases ( Figure S1).A 3.2 mm diameter disc was punched from each NDBS, immersed in 200 μL of phosphate buffered saline, and incubated at room temperature on a rotary shaker (600...

show abstract

“…An association between obesity and ASD was found, but not significant AOR: 1.37 (95% CI, 0.98-1.92). 32 Although it was observed that gains between 16 and 20 kg showed an AOR: 1.52 (95% CI, 1.05-2.22) and gains greater than 20 kg an AOR: 1.58 (95% CI, 1.08-2.31). 32 At each 2.3 kg gain the chances of developing autism increased by 6%; with AOR: 1.06 (95% CI, 1.02-1.10).…”

Section: Body Mass Index (Bmi) and Weight Gain During Pregnancymentioning

confidence: 95%

“…32 At each 2.3 kg gain the chances of developing autism increased by 6%; with AOR: 1.06 (95% CI, 1.02-1.10). 32…”

Section: Body Mass Index (Bmi) and Weight Gain During Pregnancymentioning

confidence: 95%

Perinatal Aspects and Autism Spectrum Disorder: An Update Review

Rosado¹,

Garcia²,

Coutinho³

2020

Hum. Reprod. Arch.

View full text Add to dashboard Cite

Autistic Spectrum Disorder (ASD) is understood as a group of phenotypic conditions that have in common changes in the development of sociability and communication. Methods: This is a narrative review aiming to update the proposed theme. We used population-based studies such as cohorts, case-control studies as well as previous reviews, published at PubMed, SciELO-LILACS and Cochrane library between January 2018 and May 2019. We used the descriptors: autistic disorder, combined with pregnancy and the MeSH Terms: Autism Spectrum Disorder, combined with pregnancy. 52 studies were selected and, after exclusion criteria, 34 composed this review. Results/Conclusion: Throughout the analysis of results, we could observe, despite of genetic causes, that during the whole pregnancy and postpartum period, the interaction of the pregnant women with the environment and some risk factors that may interfere in maternal-fetal health, such as parent's age, race, being migrants, hypertension, diabetes, use of anticonvulsants, acetaminophen, fetal growth restriction, pre-eclampsia, excessive weight gain and labor complications that showed association to ASD, while alcohol, smoking, folic acid use and vaccination had no association. It's up to health professionals to educate themselves even more so as to anticipate, as far as possible, the disorder and know how to deal with special children, free from prejudices and stigmata.

show abstract

Maternal Pre‐pregnancy Body Mass Index and Gestational Weight Gain in Relation to Autism Spectrum Disorder and other Developmental Disorders in Offspring

Cited by 39 publications

References 53 publications

Autism spectrum disorder

Autism spectrum disorder

Neonatal levels of acute phase proteins and risk of autism spectrum disorders

Perinatal Aspects and Autism Spectrum Disorder: An Update Review

Contact Info

Product

Resources

About