Maternal pre-pregnancy body mass index, gestational weight gain, and risk of childhood asthma/wheeze: A systematic review and meta-analysis of cohort studies

Abstract

Introduction: The goal of this study was to evaluate the association between maternal pre-pregnancy body mass index (BMI), gestational weight gain (GWG) and risk of childhood asthma/wheeze by conducting a meta-analysis of cohort studies. Methods: A systematic literature search of several databases was conducted through January 2020 to identify relevant studies. The exposure of interest was maternal pre-pregnancy BMI (e.g., underweight, overweight, obesity, and continuous BMI) and GWG (e.g., inadequate GWG, excessive GWG, GWG < 9 kg, GWG > 15 kg, and continuous GWG). Random-effects models were used