Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring

Abstract

Background Neopterin and the kynurenine/tryptophan ratio (KTR) increases with interferon-γ stimulation, indicating Th1-immunity, and thus might be inversely associated with asthma. Objective To examine the association of maternal neopterin and KTR during pregnancy with asthma in the offspring. Methods We analyzed the associations of maternal plasma total neopterin level and KTR in mid-pregnancy with asthma at 7 years among 2,883 children in the Norwegian Mother and Child Cohort Study. Asthma was classified either by registered dispensed asthma medications in the Norwegian Prescription Database or by maternal report. We calculated adjusted relative risks (RR) using log-binomial regression. Results The median (interquartile range) gestational week of blood sampling was 18 weeks (17–19 weeks). The risk of dispensed asthma medications at 7 years was highest among children of mothers in the highest quartile of neopterin level, while the risk was similar in the three lowest quartiles. The adjusted RR (95% CI) of dispensed asthma medications was 1.66 (1.16, 2.38) comparing children of mothers in the highest quartile to those in the three lowest. A similar association was observed for maternal report of asthma at 7 years. When we evaluated allergic versus non-allergic asthma, neopterin tended to be associated with non-allergic asthma. Maternal KTR was not associated with asthma development. Conclusions Our findings indicate that high maternal levels of neopterin, a marker of cellular immune activation, during pregnancy was positively associated with asthma in the offspring. Experimental studies would be needed to further elucidate underlying mechanisms.

Comparative metabolomics analysis of bronchial epithelium during barrier establishment after allergen exposure

“…On the other hand, L‐tryptophan, L‐arginine and L‐kynurenine were significantly increased on the apical compartment of ALI‐cultured Calu‐3 cells after Der p 1 exposure but not on the basolateral one, compared to both, control and Ole e 1‐exposed cells. These metabolites have been associated to allergy 31,32 . The essential amino acid L‐tryptophan is breakdown by the indoleamine 2,3‐dioxygenase (IDO) enzyme in N‐formyl‐kynurenine via the kynurenine pathway, which also include the metabolite kynurenine 33 .…”

“…These metabolites have been associated to allergy. 31 , 32 The essential amino acid L‐tryptophan is breakdown by the indoleamine 2,3‐dioxygenase (IDO) enzyme in N‐formyl‐kynurenine via the kynurenine pathway, which also include the metabolite kynurenine. 33 IDO‐1 is the predominant isoform expressed in the lung by epithelial cells among others.…”

Advances in asthma in 2016: Designing individualized approaches to management

“…67 There is also great interest in identifying biomarkers that might be reflective of asthma development in utero. Magnus et al 75 reported that high maternal levels of neopterin, a marker of cellular immune activation, during pregnancy were positively associated with asthma in offspring, but further studies are needed to identify the mechanism for this observation. There is also interest in using breathomics with the assessment of volatile organic compounds in assessment of asthma and COPD.…”

CORRELATION OF NEOPTERINE AND IFNγ LEVELS IN THE PATIENTS WITH EXACERBATION OF CHRONIC PERIODONTITIS AND INTOLERANCE OF DENTAL MATERIALS

“…Фермент GTP CH I катализирует образование 7,8 -диги-дронеоптеринтрифосфата из ГТФ. Отщепление фосфорных остатков клеточными фосфатазами приводит к образованию 7,8 дигидронеоптери-на, при неферментативном окислении которого и образуется неоптерин [12]. При патологических состояниях, связанных с активацией иммунной системы, концентрация неоптерина и 7,8 диги-дронеоптерина в организме может значительно увеличиваться.…”