Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks’ gestation in pregnancies ending in preterm delivery

Hobel, Calvin J.; Dunkel-Schetter, Christine; Roesch, Scott C.; Castro, Lony C.; Arora, Chander

doi:10.1016/s0002-9378(99)70712-x

Cited by 422 publications

(327 citation statements)

References 33 publications

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“…Já a pesquisa realizada por Lu & Chen 39 não identificou associação nas diversas classificações de estresse utilizadas: emocional, financeiro, relacionado ao parceiro e traumático. Uma explicação encontrada para a associação do estresse ao nascimento pré-termo seria pelo aumento da liberação de adrenalina, noradrenalina e cortisol no plasma, que provocam a liberação do hormônio corticotrófico placentário, desencadeando prematuramente a cadeia biológica que leva ao trabalho de parto 40 . Associa-se a isso o fato que de as mulheres expostas a situações de estresse também apresentam maior concentração plasmática de marcadores para inflamação, que pode ser um mecanismo adicional pelo qual o estresse aumenta o risco de nascimento pré-termo 5 .…”

Section: Discussionunclassified

Fatores de risco para nascimentos pré-termo em Londrina, Paraná, Brasil

et al. 2009

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IntroduçãoSegundo a Classificação Internacional de Doenças 1 , nascimento pré-termo é o que ocorre com menos de 37 semanas de gestação. Essas crianças têm um risco elevado de adoecer e morrer em razão de seu incompleto desenvolvimento fetal e maior suscetibilidade às infecções, complicadas pela manipulação e grande período de permanência nas unidades neonatais. Muitos evoluem com seqüelas neurológicas, oftalmoló-gicas ou pulmonares 2 .Os nascimentos pré-termo são classificados em dois tipos clínicos: espontâneos e por indicação médica. Os espontâneos são subdivididos em dois tipos: o primeiro denominado trabalho de parto prematuro de causa idiopáti-ca, caracteriza-se por contrações uterinas que progridem com ou sem ruptura das membranas amnióticas e o segundo quando a ruptura das membranas amnióticas antecede o trabalho de parto. O nascimento pré-termo por indicação médica ocorre quando por problemas da mãe ou do feto há contra-indicação da continuidade da gravidez 3,4,5 .O limitado conhecimento da etiologia do trabalho de parto prematuro e da ruptura prematura de membranas juntamente com a não intervenção precoce nos problemas maternos e fetais são apontados como fatores que dificultam a redução da freqüência de nascimentos pré-termo 6 .ARTIGO ARTICLE Silva AMR et al.

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Section: Discussionunclassified

Fatores de risco para nascimentos pré-termo em Londrina, Paraná, Brasil

et al. 2009

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“…One of the major placental stress signals in pregnant primates is the peptide corticotropin-releasing hormone (CRH). This peptide plays a key role in the maturation of the fetal hypothalamic-pituitary-adrenal-axis (HPA-axis) and other systems, and coordinates events that underlie both fetal growth and maturation and the time of onset of parturition (Hobel, Dunkel-Schetter, Roesch, Castro, & Arora, 1999;Sandman et al, 2006;Sandman et al, 2003;Sandman et al, 1999b;Wadhwa et al, 2004;Wadhwa, Porto, Garite, Chicz-DeMet, & Sandman, 1998).…”

Section: Introductionmentioning

confidence: 99%

Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation

Ellman

Schetter

Hobel

et al. 2008

Developmental Psychobiology

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The purpose of the study was to determine the specific periods during pregnancy in which human fetal exposure to stress hormones affects newborn physical and neuromuscular maturation. Blood was collected from 158 women at 15, 19, 25, and 31 weeks' gestation. Levels of placental corticotropin-releasing hormone (CRH) and maternal cortisol were determined from plasma. Newborns were evaluated with the New Ballard Maturation Score. Results indicated that increases in maternal cortisol at 15, 19, and 25 weeks and increases in placental CRH at 31 weeks were significantly associated with decreases in infant maturation among males (even after controlling for length of gestation). Results also suggested that increases in maternal cortisol at 31 weeks were associated with increases in infant maturation among females, although these results were not significant after controlling for length of gestation. Findings suggest that stress hormones have effects on human fetal neurodevelopment that are independent of birth outcome.

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“…Krackow (18), among others (19), characterizes the connection between offspring gender and likelihood of grandchildren, at least among higher vertebrates, as implausible. The statistical association between the sex ratio and ambient stressors more likely arises as a byproduct of the damage done to mothers and, in turn, embryos and fetuses by the stress response (20)(21)(22). Unlike the ''culled cohort'' argument, this ''damaged cohort'' mechanism does not assume maternal manipulation of the criterion for spontaneous abortion.…”

mentioning

confidence: 98%

Secondary sex ratios and male lifespan: Damaged or culled cohorts

Catalano

Bruckner

2006

Proc. Natl. Acad. Sci. U.S.A.

117

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Population stressors reportedly reduce the human secondary sex ratio (i.e., the odds of a newborn's being male) by, among other mechanisms, inducing the spontaneous abortion of males who would have been born live had mothers not been stressed. Controversy remains as to whether these abortions result from reduced maternal tolerance of males at the low end of a relatively constant distribution of survivability (i.e., the ''culled cohort'' explanation) or from shifts in the whole distribution of survivability such that more males fall below a relatively constant criterion of maternal tolerance for low survivability (i.e., the ''damaged cohort'' explanation). These alternatives make opposing predictions regarding the relationship between the secondary sex ratio and lifespan of male birth cohorts. We test the hypothesis that the secondary sex ratio among Swedish cohorts born in the years 1751 through 1912 predicts male cohort life expectancy at birth (i.e., realized lifespan). Our results support the culled cohort argument. We argue that these findings have implications for the basic literature concerned with temporal variation in the secondary sex ratio, for more applied work concerned with the fetal origins of adult health, and for pub ic health surveillance.fetal death ͉ life expectancy ͉ time series ͉ population health

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Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks’ gestation in pregnancies ending in preterm delivery

Cited by 422 publications

References 33 publications

Fatores de risco para nascimentos pré-termo em Londrina, Paraná, Brasil

Fatores de risco para nascimentos pré-termo em Londrina, Paraná, Brasil

Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation

Secondary sex ratios and male lifespan: Damaged or culled cohorts

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