Maternal Pesticide Exposure and Neural Tube Defects in Mexican Americans

Brender, Jean D.; Felkner, Marilyn; Suarez, Lucina; Canfield, Mark A.; Henry, Judy

doi:10.1016/j.annepidem.2009.09.011

Cited by 67 publications

(51 citation statements)

References 20 publications

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“…In Texas, Mexican women who reported using pesticides in their homes were 2 times more likely to have a live birth with spina bifida or anencephaly than non-exposed women [17]. Women with a neural tube defect-affected baby were also more likely to report living in the proximity to cultivated fields than control women [17]. Another study among Mexican women reported that working in agriculture around the time of conception was associated with a greater risk of anencephaly in the offspring [22].…”

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 92%

“…Maternal exposure to domestic pesticides during the 1st trimester of pregnancy was associated with transposition of the great arteries in the offspring, particularly for exposure to herbicides and rodenticides [24]. Several other epidemiological studies also reported associations between pesticide exposure and a variety of congenital anomalies, particularly in the offspring of agricultural workers, in infants born to women living in the proximity of pesticide application areas or in babies conceived in a particular season [3,[16][17][18]20,22,23,36]. In Brazil, one study found a greater risk of congenital defects in births to parents exposed to pesticides at work or due to proximity to an application area [20].…”

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 97%

“…Women's pesticide exposures through household gardening, professional application or living in close proximity to agricultural crops were associated with increased risks of their offspring having neural tube defects and limb anomalies [36]. In Texas, Mexican women who reported using pesticides in their homes were 2 times more likely to have a live birth with spina bifida or anencephaly than non-exposed women [17]. Women with a neural tube defect-affected baby were also more likely to report living in the proximity to cultivated fields than control women [17].…”

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 99%

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Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil

Cremonese¹,

Freire²,

Camargo³

et al. 2014

International Journal of Occupational Medicine and Environmental Health

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Objectives: To investigate the association between per capita pesticide consumption and infant mortality rates from CNS and CVS congenital malformations in microregions in the South and Southeast Region of Brazil. Material and Methods: An ecological study was conducted using data on pesticide expenditure in 1985 and 1996, and deaths caused by CNS and CVS malformations in infants under 1 year old in 1986-1990 and 1997-2001, respectively. Per capita pesticide consumption and infant mortality rates were calculated for each microregion. Microregions were grouped according to quintiles of pesticide consumption, taking the first quintile as reference. The association between pesticide consumption and infant mortality was examined by calculating Spearman correlation coefficients (r) and mortality rate ratios (RR), stratifying by gender and type of microregion (urban or rural). Results: Significant and positive correlations between per capita pesticide consumption and rates of mortality due to CNS and CVS defects were observed in rural but not urban microregions. In general, mortality RRs for the 2 types of malformations in rural microregions were significantly higher in each quintile of pesticide consumption compared to the lowest quintile in the 2 study periods, with elevations ranging between 10% and 30%. Likewise, mortality RRs in these microregions showed significant trends of increase across quintiles of pesticide consumption in both study periods. In urban areas, however, mortality RRs from both CNS and CVS malformations were weak and not statistically significant, and a trend of increase of mortality with increasing pesticide usage was not observed. Conclusions:The results show the relevance of pesticide exposure in rural areas with intense agricultural activity, suggesting that such prenatal exposures may be related with the occurrence of certain congenital defects.

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Section: Ijomeh 2014;27(3) 482mentioning

confidence: 92%

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 97%

Section: Ijomeh 2014;27(3) 482mentioning

confidence: 99%

See 1 more Smart Citation

Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil

Cremonese¹,

Freire²,

Camargo³

et al. 2014

International Journal of Occupational Medicine and Environmental Health

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“…A possible association between pesticide exposure and the risk of NTDs has been suggested in several epidemiological studies (10,11). However, all of these studies relied on self-reported pesticide exposure or used occupation or job title as surrogates for actual pesticide exposure data.…”

Section: Discussionmentioning

confidence: 99%

“…In a case-control study conducted in the United States, pregnant women who reported that an insect control professional applied pesticides to their homes had a 60% increased risk of having an NTD-affected pregnancy compared with those women who had no such pesticide exposure during their pregnancies (10). Mexican American women who reported using pesticide in their homes or yards were twice as likely to have pregnancies affected by NTDs than those who reported no pesticide use (11). In California, the NTD risk was found to be weakly associated with periconceptional maternal residential proximity to National Priority List sites containing PCBs (12).…”

mentioning

confidence: 99%

Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects

Ren

Qiu

Jin

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

255

169

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Persistent organic pollutants (POPs) have been associated with a wide range of adverse health effects. Our case-control study was performed to explore the association between placental levels of selected POPs and risks for neural tube defects (NTDs) in a Chinese population with a high prevalence of NTDs. Cases included 80 fetuses or newborns with NTDs, whereas the controls were 50 healthy, nonmalformed newborn infants. Placental concentrations of polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides, polychlorinated biphenyls, and polybrominated diphenyl ethers were analyzed by gas chromatography-mass spectrometry. The medians of PAHs, o,p′-isomers of dichlorodiphenyltrichloroethane (DDT) and metabolites, α-and γ-hexachlorocyclohexane (HCH), and α-endosulfan were significantly higher in case placentas than in controls. PAH concentrations above the median were associated with a 4.52-fold [95% confidence interval (CI), 2.10-9.74) increased risk for any NTDs, and 5.84-(95% CI, 2.28-14.96) and 3.71-fold (95% CI, 1.57-8.79) increased risks for anencephaly and spina bifida, respectively. A dose-response relationship was observed between PAH levels and the risk of NTDs, with odds ratios for the second, third, and fourth quartiles, compared with the first, of 1.77-(95% CI, 0.66-4.76), 3.83-(95% CI, 1.37-10.75), and 11.67-fold (95% CI, 3.28-41.49), respectively. A dose-response relationship was observed for anencephaly and spina bifida subtypes. Similar results were observed for o,p′-DDT and metabolites, α-HCH, γ-HCH, and α-endosulfan, whereas no dose-response relationship was observed for the last two pollutants. Elevated placental concentrations of PAHs, o,p′-DDT and metabolites, and α-HCH were associated with increased risks of NTDs in this population.congenital abnormalities | indoor air pollution

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Finding the genetic mechanisms of folate deficiency and neural tube defects—Leaving no stone unturned

Findley

2017

American J of Med Genetics Pt A

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Neural tube defects (NTDs) occur secondary to failed closure of the neural tube between the third and fourth weeks of gestation. The worldwide incidence ranges from 0.3 – 200 per 10,000 births with the United States of American NTD incidence at around 3–6.3 per 10,000 dependent on race and socioeconomic background. Human NTD incidence has fallen by 35–50% in North America due to mandatory folic acid fortification of enriched cereal grain products since 1998. The US Food and Drug Administration has approved the folic acid fortification of corn masa flour with the goal to further reduce the incidence of NTDs, especially among individuals who are Hispanic. However, the genetic mechanisms determining who will benefit most from folate enrichment of the diet remains unclear despite volumes of literature published on studies of association of genes with functions related to folate metabolism and risk of human NTDs. The advances in omics technologies provides hypothesis-free tools to interrogate every single gene within the genome of NTD affected individuals to discover pathogenic variants and methylation targets throughout the affected genome. By identifying genes with expression regulated by presence of folate through transcriptome profiling studies, the genetic mechanisms leading to human NTDs due to folate deficiency may begin to be more efficiently revealed.

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Maternal Pesticide Exposure and Neural Tube Defects in Mexican Americans

Cited by 67 publications

References 20 publications

Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil

Pesticide consumption, central nervous system and cardiovascular congenital malformations in the South and Southeast region of Brazil

Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects

Finding the genetic mechanisms of folate deficiency and neural tube defects—Leaving no stone unturned

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