Maternal Periodontal Disease and Risk of Preeclampsia: A Case-Control Study

Lohsoonthorn, Vitool; Kungsadalpipob, Kajorn; Chanchareonsook, Prohpring; Limpongsanurak, Sompop; Vanichjakvong, Ornanong; Sutdhibhisal, Sanutm; Sookprome, Chulamanee; Wongkittikraiwan, Nopmanee; Kamolpornwijit, Wiboon; Jantarasaengaram, Surasak; Manotaya, Saknan; Siwawej, Vatcharapong; Barlow, William E.; Fitzpatrick, Annette L.; Williams, Michelle A.

doi:10.1038/ajh.2008.365

Cited by 25 publications

(38 citation statements)

References 36 publications

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“…Only two studies [63], [64] gained the maximum score in the Selection outcome; nine studies [15], [19], [24], [25], [26], [52], [63], [64], [65] had the maximum score in the Comparability outcome; and all studies had a partial score in the Exposure outcome.…”

Section: Resultsmentioning

confidence: 94%

“…The sample size varied from 54 patients in the study of Chaparro et al [60] to 1206 in the study of Siqueira et al [67]. Three studies [24], [26], [66] did not found a positive association between PD and PE, whereas the remaining studies reported a significant association.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen of the remaining 30 [45]–[59] articles were further excluded (κ = 1). Finally, 15 studies [14], [15], [19], [24]–[26], [60]–[68] qualified for inclusion in the systematic review and meta-analysis (κ = 1). The list of the excluded studies and their reasons for exclusion are provided in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…Contradictory findings exist regarding the relationship between PD and PE [15], [24]–[26], and a previous systematic review did not clarify this possible association [27]. Therefore, there is a need for a systemic assessment of the literature on the possible association between PD and PE.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis

et al. 2013

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BackgroundStudies have suggested controversial results regarding a possible association between pre-eclampsia (PE) and periodontal disease (PD) and no meta-analysis has been performed to clarify this issue.MethodsA literature search of electronic databases was performed for articles published through March 24, 2013, followed by a manual search of several dental and medical journals. The meta-analysis was conducted according to the recommendations of the Cochrane Collaboration and PRISMA. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the χ2-based Cochran Q test and I2 statistic. The level of significance was set at P <0.05.ResultsFifteen studies were included, including three cohort and 12 case-control studies. A positive association was found between PE and PD (OR 2.17, 95% CI 1.38–3.41, P = 0.0008). However, a high and significant heterogeneity was found (χ2 = 62.42, P<0.00001, I2 = 75%). In most cases, subgroup analysis had low power to detect significant differences between PE and non-PE groups.ConclusionBased on the findings of the meta-analysis, PD appears to be a possible risk factor for PE. However, given the important differences in the definitions and diagnoses of PD and PE among the studies, as well as their lack of good methodological quality, future trials are needed to confirm the results of the present meta-analysis.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between Periodontitis and Pre-Eclampsia: A Meta-Analysis

et al. 2013

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“…In 2003, the first study that suggested that periodontitis could increase the risk of preeclampsia was published 22 . Although observational studies 23‐31 and randomized controlled trials (RCTs) 32‐34 have since been performed, as yet there is insufficient scientific evidence to support this association. This is possibly attributable to a number of reasons, such as the lack of a standard definition for periodontitis, methodologic errors involving sample selection, the best manner in which to analyze risk factors common to the two diseases, and, of course, problems related to studies conducted among differing population groups.…”

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confidence: 99%