Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia

Sibai, Baha M.; Taslimi, M. Mark; El-Nazer, Adel; Amon, Erol; Mabie, Bill; Ryan, George M.

doi:10.1016/0002-9378(86)90266-8

Cited by 546 publications

(334 citation statements)

References 10 publications

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“…Kliniğimizde Ocak 2005 ile Aralık 2010 tarihleri arasında HELLP sendromu tanısı konulan 155 hastanın, hastane bilgisayar sistemindeki kayıt-ları geriye dönük olarak değerlendirildi. HEL-LP sendromu tanısı Sibai [5] tanı kriterlerine göre koyuldu.…”

Section: Gereç Ve Yöntemunclassified

“…Maternal ve fetal iyilik durumunun ani ve çoğu zaman da hızlı şekilde bozulması ile karakterizedir. Maternal mortalite %1-3, perinatal mortalite ise %35 oranında bildirilmiştir [3][4][5]. Çalışmamızda HELLP sendromu tanısı ile takip edilmiş olan hastalarımızın demografik özellikler ve laboratuvar verileri retrospektif olarak incelenerek maternal ve perinatal sonuçları etkileyen risk faktörlerinin değerlendirilmesi planlandı.…”

Section: Introductionunclassified

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Hellp sendromu tanısı alan hastaların maternal ve fetal sonuçlarının analizi

Esenkaya

İngeç

Yılmaz

et al. 2016

Zeynep Kamil Tıp Bülteni

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Section: Gereç Ve Yöntemunclassified

Section: Introductionunclassified

Hellp sendromu tanısı alan hastaların maternal ve fetal sonuçlarının analizi

Esenkaya

İngeç

Yılmaz

et al. 2016

Zeynep Kamil Tıp Bülteni

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“…HELLP syndrome was defined as new onset of severe hypertension (systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥110 mmHg) with platelet count <100,000 cells/mm 3 , aspartate aminotransferase activity >70 U/L, and lactate dehydrogenase activity >600 U/L (Sibai et al 1986), in the absence of other pathologic conditions. The control group included women with normal pregnancy and normal fetal growth.…”

Section: Tissue Samplesmentioning

confidence: 99%

The role of p38α mitogen-activated protein kinase gene in the HELLP syndrome

Corradetti

Saccucci

Emanuelli

et al. 2010

Cell Stress and Chaperones

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Mitogen-activated protein kinase (MAPK) p38α was shown to be implicated in the organogenesis of the placenta, and such placental alteration is crucial for the development of hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome. We aimed to analyze for the first time human placental expression of MAPK p38α in pregnancies complicated by HELLP. The placental expression of MAPK p38α was investigated by semiquantitative polymerase chain reaction using cDNA extracted from placental tissue of 15 pregnancies with HELLP syndrome and 15 gestational age-matched controls. Seven patients with HELLP also had intrauterine fetal growth restriction (IUGR). In placenta from pregnancy complicated by HELLP, the expression of MAPK p38α is significantly decreased compared to the group with normal pregnancy (p<0.001), while no difference was found between the HELLP and HELLP with IUGR subpopulations. Our study shows for the first time that MAPK p38α is expressed in the human placenta. Pregnancies with placental dysfunction and hypertensive complications are characterized by a significantly decreased expression of MAPK p38α. Our observations suggest that p38 MAPK signaling may be essential in placental angiogenesis and functioning.

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“…In another report, epidural bleeding has been associated with epidural anesthesia in patients with HELLP syndrome. 21 Furthermore, disseminated intravascular coagulation may occur with HELLP syndrome in up to 39% of patients. 22 Compared to PDPH, the headache of intracranial hematoma is associated with focal neurological abnormalities and signs of increased intracranial pressure (ICP) such as confusion and vomiting.…”

Section: Figure Brain Magnetic Resonance Imaging Showing Bilateral Tementioning

confidence: 99%

Intracranial subdural hematoma following dural puncture in a parturient with HELLP syndrome

Ezri

Abouleish²,

Lee³

et al. 2002

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To present a case of postpartum bilateral intracranial subdural hematoma after dural puncture during attempted epidural analgesia for labour.C Cl li in ni ic ca al l f fe ea at tu ur re es s: : This complication occurred following accidental dural puncture in a parturient with thrombocytopenia (99,000·µL -1 ) who subsequently developed the syndrome of hemolysis, elevated liver enzymes and low platelets. On the first postoperative day, postdural puncture headache (PDPH) developed. An epidural blood patch (EBP) was deferred to the third postoperative day because of a platelet count of 21,000·µL -1 . However, the headache intensified from a typical PDPH to one which was not posturally related. A second EBP was abandoned after the injection of 5 mL of blood because of increasing headache during the procedure. Magnetic resonance imaging revealed bilateral temporal subdural hematomas. The patient was managed conservatively and discharged home without any sequelae.

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Maternal-perinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia-eclampsia

Cited by 546 publications

References 10 publications

Hellp sendromu tanısı alan hastaların maternal ve fetal sonuçlarının analizi

Hellp sendromu tanısı alan hastaların maternal ve fetal sonuçlarının analizi

The role of p38α mitogen-activated protein kinase gene in the HELLP syndrome

Intracranial subdural hematoma following dural puncture in a parturient with HELLP syndrome

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